Indications 

Tribenzor is a prescribed medication used to treat hypertension (high blood pressure) either on its own or in combination with other antihypertensive drugs. Reducing blood pressure helps mitigate the likelihood of life-threatening cardiovascular events, predominantly strokes and myocardial infarctions. 

Tribenzor comprises three medications: olmesartan, an angiotensin receptor blocker (ARB), amlodipine, a calcium channel blocker, and hydrochlorothiazide, a diuretic.  

Olmesartan and amlodipine function by promoting blood vessel relaxation, facilitating improved blood flow. Conversely, hydrochlorothiazide works by enhancing salt and water excretion through increased urine production. 

Uses and Dosage 

Before taking Tribenzor and with every prescription refill, carefully review its medication guide and patient information leaflet. For any concerns, consult your healthcare provider or pharmacist. 

The dosage of Tribenzor is determined based on the patient’s medical condition and response to the treatment. 

Typically, Tribenzor is taken once daily as prescribed by the doctor, without regard to food intake. 

To ensure optimal results, follow the prescribed regimen for this medication diligently, taking it at consistent times every day. 

Keep taking Tribenzor even if you are feeling well, as many individuals with high blood pressure may not experience symptoms.  

Inform your doctor if there is no improvement in your condition or if it deteriorates (blood pressure readings remain elevated or escalate). 

Side Effects 

Listed below are the potential adverse effects of Tribenzor. Promptly notify your doctor if any of these symptoms persist or deteriorate. 

Common Side Effects 

• Dizziness 
• Headache and fatigue 
• Swelling in hands or feet 
• Nausea and diarrhea 
• Runny or stuffy nose, sore throat 
• Muscle spasms 
• Swollen joints 
• Painful urination 

Serious Side Effects 

• Worsening chest pain 
• Feeling lightheaded or at risk of fainting 
• Development of an unusual skin rash 
• Pain or burning sensation during urination 
• Severe or persistent diarrhea resulting in weight loss 
• Experiencing blurred or tunnel vision, eye pain, or seeing halos around lights 
• Symptoms of kidney problems, such as: 
  • Reduced urination 
  • Swelling in feet or ankles 
  • Fatigue 
  • Breathlessness 
• Signs of an electrolyte imbalance, including: 
  • Increased thirst or urination 
  • Confusion 
  • Vomiting 
  • Constipation 
  • Muscle pain or weakness 
  • Leg cramps 
  • Low energy 
  • Irregular heartbeats 
  • Numbness 
  • Tingling 
  • Loss of movement 

Inform your doctor right away if you experience any of the serious side effects listed above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Tribenzor may occur. Immediate medical assistance is required upon noticing any signs of an allergic reaction, including: 

• Hives 
• Breathing difficulties 
• Swelling of the face, lips, tongue, or throat 

Not all side effects of Tribenzor are included in this list. Inform your doctor if any unlisted effects are experienced. 

Cautions 

Before starting treatment with Tribenzor, inform your doctor if you have any known allergies, particularly to: 

• Olmesartan 
• Amlodipine 
• Hydrochlorothiazide 

Consult your pharmacist for further details on Tribenzor, as it could potentially include inactive components that may lead to allergic reactions or other complications. 

To ensure Tribenzor is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Kidney disease 
• Liver disease 
• Dehydration 
• Untreated electrolyte imbalances (e.g., high/low potassium, low magnesium, high calcium) 
• Gout 
• Lupus 
• Aortic stenosis 
• Skin cancer 

Notify all healthcare providers of any current or recently started or stopped medications, including prescription and over-the-counter drugs, vitamins, and herbal supplements, to minimize the possibility of drug interaction with Tribenzor. 

Some products that may interact with Tribenzor include: 

• Aliskiren 
• Dofetilide 
• Lithium 
• Medications that can elevate blood potassium levels, including: 
  • Sparsentan 
  • ACE inhibitors (e.g., benazepril and lisinopril) 
  • Birth control pills containing drospirenone 

If you are on cholesterol-lowering drugs like cholestyramine or colestipol, make sure to take Tribenzor either 4 hours before or 4 to 6 hours after these medications. 

Notify your pharmacist about the products you are using as some may contain ingredients that can elevate blood pressure. Seek advice on their proper usage, especially when it comes to cough-and-cold remedies, dietary supplements, or NSAIDs such as ibuprofen and naproxen. 

Prior to consuming potassium supplements or salt substitutes containing potassium, consult with your doctor or pharmacist due to the potential impact of Tribenzor on potassium levels. 

Patients with diabetes should monitor their blood sugar levels regularly while taking Tribenzor and report the findings to their doctor. Adjustments to diabetes medication, exercise regimen, or diet may be necessary as advised by the doctor. 

Lab tests may be affected by Tribenzor, resulting in potential inaccuracies in the test outcomes. Communicate your usage of this medication to lab personnel and all medical professionals involved. 

Hydrochlorothiazide heightens the likelihood of developing skin cancer.  Avoiding direct sunlight and tanning beds is recommended. When outdoors, don protective attire and apply sunscreen with an SPF of 30 or above. Regular skin check-ups may be recommended by your physician. 

Excessive sweating, diarrhea, or vomiting can heighten the likelihood of feeling dizzy or dehydrated. Inform your physician if you experience prolonged bouts of diarrhea or vomiting. To avoid dehydration while taking Tribenzor, ensure an ample intake of fluids unless otherwise instructed by your doctor. 

Do not utilize Tribenzor if you are pregnant, as olmesartan can pose a risk of harm or fatality to the unborn child when taken during the second or third trimester. Promptly inform your healthcare provider if you become pregnant while on this medication. 

The transfer of olmesartan into breast milk is uncertain, whereas hydrochlorothiazide and amlodipine do pass into breast milk. Prior to breastfeeding, consult with your healthcare provider.