Cortisporin Ophthalmic Suspension (Neomycin/Polymyxin B/Hydrocortisone) Medication

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Drug Description


Cortisporin Ophthalmic Suspension is prescribed for managing eye inflammation resulting from uveitis, eye injury, radiation, chemical burns, and certain other eye conditions. 

Moreover, Cortisporin Ophthalmic Suspension is prescribed when there is a potential for bacterial infection in or around the eye. 

Cortisporin Ophthalmic Suspension contains neomycin and polymyxin, which are antibiotics, along with hydrocortisone, an anti-inflammatory corticosteroid.  

Neomycin and polymyxin work by inhibiting bacterial growth, while hydrocortisone, on the other hand, works by reducing inflammation. 

Uses and Dosage 

Before using Cortisporin Ophthalmic Suspension and with every prescription refill, carefully read the accompanying medication guide and patient information leaflet. If you have any queries or need further clarification, do not hesitate to seek guidance from your doctor or pharmacist. 

Typically, one or two drops of Cortisporin Ophthalmic Suspension are applied to the affected eye every 3 or 4 hours, adjusted according to the severity of the condition. It can be used more often if needed. 

To properly apply this suspension: 

  1. Wash your hands thoroughly.  
    • Do not touch the dropper tip and avoid any contact between the dropper tip and your eye or any surfaces to prevent contamination. 
  2. Shake the bottle well before each application. 
  3. Tilt your head back, gaze upward, and gently pull down your lower eyelid to create a small pocket. 
  4. Directly position the dropper over your eye and dispense a single drop into the pocket. 
  5. Look downward and gently close your eyes for 1 to 2 minutes.  
    • Place a finger at the corner of your eye near your nose and apply gentle pressure to prevent the medication from draining out.  
    • Do not blink or rub your eyes during this time. 
  6. If directed and if your dosage requires more than one drop, repeat steps 2-5 for your other eye. 
  7. Do not rinse the dropper. After each use, replace the dropper cap securely. 

For effective infection clearance, continue to use Cortisporin Ophthalmic Suspension for the entire prescribed treatment duration, even if your symptoms have resolved. Use it exactly as directed, and do not skip any doses. 

Notify your doctor if your condition does not improve within 48 hours of starting treatment with this medication. 

Side Effects 

The potential adverse effects of Cortisporin Ophthalmic Suspension are outlined below. Promptly inform your doctor if any of these symptoms continue or deteriorate. 

Common Side Effects 

  • Mild eye itching or irritation 
  • Eye redness 

Serious Side Effects 

  • Intense itching, redness, or swelling in the eyes 
  • Indication of an infection: 
  • Eye discomfort, crusting, or unusual discharge  
  • Blurred vision, tunnel vision, eye pain, or perceiving halos around lights 
  • Pain located behind the eyes, sudden alterations in vision 
  • A non-healing wound 

Immediately inform your doctor if you experience any severe side effects. 

Allergic Reactions 

In rare cases, Cortisporin Ophthalmic Suspension may trigger a severe allergic response. Urgent medical aid should be sought if any symptoms of an allergic reaction are noticed, including: 

  • Hives 
  • Difficulty breathing 
  • Face, tongue, or throat swelling 
  • Severe Dizziness 

This list does not cover all side effects of Cortisporin Ophthalmic Solution. Should you notice any unlisted effects, consult your doctor or pharmacist. 


Before starting treatment with Cortisporin Ophthalmic Suspension, inform your doctor if you have any known allergies, particularly to: 

  • Neomycin 
  • Polymyxin B 
  • Hydrocortisone 
  • Aminoglycoside antibiotics (e.g., gentamicin, tobramycin) 
  • Corticosteroids (e.g., dexamethasone, prednisone) 

Ask your pharmacist for more information about Cortisporin Ophthalmic Suspension, as it may contain inactive ingredients that can trigger allergic reactions or other problems.  

Disclose to your doctor your medical background before using Cortisporin Ophthalmic Suspension to ensure its appropriateness for your condition, especially if you have a history of glaucoma or cataracts. 

To avoid potential interactions with Cortisporin Ophthalmic Suspension, make sure to inform your doctor about all your current or intended medications, including prescription drugs, over-the-counter remedies, dietary supplements, and herbal products. 

Following the application of Cortisporin Ophthalmic Suspension, individuals may encounter transient blurring or instability of vision. Until it is deemed safe, abstain from activities such as driving, using machinery, or any task necessitating clear vision. 

Regular monitoring of intraocular pressure is recommended when Cortisporin Ophthalmic Suspension is administered for 10 days or more. 

The potential harm of Cortisporin Ophthalmic Suspension to an unborn baby is uncertain. Notify your doctor of your pregnancy status before using this medication. 

Breastfeeding is contraindicated during the use of Cortisporin Ophthalmic Suspension. 

Additional information

Generic name:

Neomycin/Polymyxin B/Hydrocortisone


Ophthalmic Suspension



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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Cortisporin Ophthalmic Suspension (Neomycin/Polymyxin B/Hydrocortisone). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Cortisporin Ophthalmic Suspension (Neomycin/Polymyxin B/Hydrocortisone).