Indications  

Salagen is a prescribed medication for treating dry mouth symptoms caused by Sjogren’s syndrome (an autoimmune disease) or radiation-induced damage to the salivary glands during cancer treatment in the head and neck area. 

As a cholinergic agonist, Salagen functions by stimulating specific nerves to enhance saliva production, facilitating improved ease and comfort during speaking and swallowing. 

Uses and Dosage 

Before starting treatment with Salagen and with each prescription refill, carefully review its medication guide and patient information leaflet. Do not hesitate to consult your doctor or pharmacist for any inquiries. 

The dosage of Salagen is determined based on the patient’s medical condition and response to treatment. 

Typically, this medication is taken 3 to 4 times a day as prescribed by the doctor, without regard to food intake. 

For individuals with liver complications, a twice-a-day regimen of this medication may be recommended by the doctor. 

For optimal results, take Salagen exactly as directed, around the same time each day. Do not alter the prescribed dosage and frequency of intake without consulting your doctor. 

Side Effects 

Listed below are the potential adverse effects of Salagen. Notify your doctor right away if any of them persist or worsen. 

Common Side Effects 

• Increased sweating or excessive urination 
• Chills or flushing (warmth, redness, or a tingling sensation) 
• Headache, dizziness, or weakness 
• Nausea, vomiting, or diarrhea 
• Blurred vision or watery eyes 
• Runny nose 

Serious Side Effects 

• Shortness of breath 
• Rapid or slow heart rate 
• Severe headache, pounding in the neck or ears 
• Confusion and tremors 
• A light-headed feeling, potentially leading to fainting 

Stop taking Salagen and call your doctor right away if you encounter any of the serious side effects listed above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Salagen may occur. Seek prompt medical attention if you encounter any signs of an allergic response, such as: 

• Hives 
• Breathing difficulties 
• Face, lips, tongue, or throat swelling 

Not all side effects of Salagen are included in this list. Tell your doctor right away if any unlisted effects occur. 

Cautions 

Before starting treatment with Salagen, inform your doctor if you have any known allergies, particularly to pilocarpine or other medications. 

Consult your pharmacist for additional details about Salagen, as it may contain inactive ingredients that may prompt allergic reactions or other complications. 

To ensure Salagen is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Breathing problems (e.g., asthma, chronic bronchitis, COPD) 
• Certain eye conditions (e.g., night blindness, acute iritis, narrow-angle glaucoma) 
• Heart disease (e.g., chest pain, heart failure, heart attack, slow heartbeat) 
• Low or high blood pressure 
• Liver problems 
• Gallbladder disease (e.g., gallstones) 
• Kidney stones 
• Mental/mood disorders (e.g., depression, psychoses, thinking/understanding problems like dementia, Alzheimer’s) 
• Stomach problems (e.g., chronic heartburn, ulcer) 

Salagen may interact with other medications, including beta-blockers (e.g., propranolol, metoprolol). To minimize the risk of such drug interactions, inform all your healthcare providers of any current or recently started or stopped medications, including prescription and over-the-counter drugs, vitamins, and herbal supplements. 

Salagen can affect vision, particularly in low light or during nighttime. Exercise caution while driving at night or engaging in hazardous tasks under dim lighting conditions. 

The use of Salagen may induce excessive sweating, leading to dehydration. Ensure adequate water intake and promptly consult your physician if you experience challenges in consuming enough fluids or suspect dehydration. 

Salagen can potentially induce tear production, benefiting individuals with dry eyes, like those with Sjogren’s syndrome. Inform your healthcare provider if excessive tearing becomes troublesome. 

Consult with your physician prior to taking Salagen if you or your partner desire to conceive, as this medication may potentially impair fertility in both genders. 

Salagen should only be used when necessary during pregnancy. Consult your doctor to weigh the risks and benefits of this medication. 

The transfer of pilocarpine in breast milk and its impact on a nursing baby is not yet established. Before breastfeeding, seek advice from your doctor.