Uribel (Methenamine/Methylene blue/ Sodium Phosphate Monobasic/Phenyl Salicylate/Hyoscyamine) Medication


Uribel (Methenamine/Methylene blue/ Sodium Phosphate Monobasic/Phenyl Salicylate/Hyoscyamine)

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Drug Description


Uribel is a prescribed medication used to treat irritative voiding symptoms, alleviate local symptoms like inflammation, hypermotility, and pain associated with lower urinary tract infections, and provide relief from urinary tract symptoms resulting from diagnostic procedures. 

Uribel is a composite medication comprising methenamine, methylene blue, sodium phosphate monobasic, phenyl salicylate, and hyoscyamine. 

Methenamine is an antibacterial agent, while methylene blue is categorized as a monoamine oxidase inhibitor (MAO inhibitor); both aid in inhibiting bacterial growth in urine. Phenyl salicylate, akin to aspirin, provides pain relief. Sodium phosphate acts as an acidifier, making urine more acidic to enhance the effectiveness of methenamine. Lastly, hyoscyamine is an antispasmodic drug that relaxes urinary tract muscles, alleviating cramps and spasms. 

Uses and Dosage 

Before taking Uribel and with every prescription refill, carefully review its medication guide and patient information leaflet. If you have any concerns, do not hesitate to consult your healthcare provider or pharmacist. 

The dosage of Uribel is determined based on the patient’s medical condition, age, and response to the treatment.  

Typically, Uribel is taken four times daily as prescribed by the doctor, with each dose accompanied by a full glass of water. In the event of stomach upset, this medication may be taken with food. 

For optimal efficacy, take this medication exactly as directed at evenly spaced intervals and consistently at the same time each day. Do not exceed the prescribed dose, frequency, or duration of intake, as doing so will not expedite recovery and may heighten the risk of side effects. 

Side Effects 

Listed below are the potential adverse effects of Uribel. Promptly notify your doctor if any of these symptoms persist or worsen. 

Common Side Effects 

  • Dizziness or drowsiness 
  • Dry mouth 
  • Nausea or vomiting 

Serious Side Effects 

  • Severe dizziness, blurred vision, or a rapid heartbeat 
  • Painful or difficult urination 
  • Shortness of breath 

Stop taking Uribel and contact your doctor right away if you experience any of the above-listed serious side effects. 

Allergic Reactions 

Although rare, a severe allergic reaction to Uribel may occur. Prompt medical attention is necessary upon observing any indications of an allergic response, including: 

  • Hives 
  • Difficulty in breathing 
  • Itchiness or swelling in the face, lips, tongue, or throat 

Not all side effects of Uribel are included in this list. Inform your doctor if any unlisted effects are encountered. 


Before initiating Uribel treatment, inform your doctor of any known allergies, particularly to: 

  • Methenamine 
  • Methylene blue 
  • Sodium phosphate monobasic 
  • Phenyl salicylate 
  • Hyoscyamine 
  • Aspirin or NSAIDs (e.g., ibuprofen) 
  • Belladonna alkaloids (e.g., atropine, scopolamine) 

Seek further guidance from your pharmacist regarding Uribel, as it may include inactive components that can potentially trigger allergic reactions or other complications. 

To ensure Uribel is safe for you, disclose to your physician your medical background, especially if you have a history of: 

  • Kidney or liver problems 
  • Urinary blockage issues or difficulties urinating, such as due to an enlarged prostate 
  • Stomach or intestinal disorders, like obstructions or ulcers 
  • Narrow-angle glaucoma 
  • Heart conditions, including coronary heart disease, congestive heart failure, or fast/irregular heartbeat 
  • High blood pressure 
  • Myasthenia gravis 
  • Bleeding or clotting disorders 
  • Pyruvate kinase or G6PD deficiency 
  • Aspirin-sensitive asthma (a history of worsened breathing and nasal symptoms after taking aspirin or NSAIDs) 
  • Nasal polyps 
  • Severe/frequent headaches 
  • Stroke 
  • A specific type of adrenal gland tumor known as pheochromocytoma 
  • Dehydration 

Inform all your healthcare providers of any current or recently started or stopped medications, including prescription and over-the-counter drugs, vitamins, and herbal supplements, to mitigate the risk of drug interaction with Uribel. 

Some of the products that may interact with Uribel include: 

  • Apraclonidine 
  • Atomoxetine 
  • Bupropion 
  • Carbamazepine 
  • Dichlorphenamide 
  • Methotrexate 
  • Mifepristone 
  • Potassium capsules/tablets 
  • Pramlintide 
  • Tetrabenazine 
  • Certain Parkinson’s disease medicine (entacapone, levodopa, tolcapone) 
  • Specific high blood pressure medications (guanethidine, methyldopa) 
  • Sulfonamide drugs, including sulfa antibiotics like sulfamethoxazole 
  • Sympathomimetics such as amphetamine and ephedrine 
  • Products that reduce urinary acid levels, like antacids, sodium bicarbonate, potassium/sodium citrate, and acetazolamide 

Concurrent use of Uribel with other medications that possess bleeding tendencies, such as anti-platelet drugs (e.g., clopidogrel) and blood thinners (e.g., dabigatran, enoxaparin, warfarin), may amplify the likelihood of bleeding occurrences. 

Concurrent use of Uribel with other MAO inhibitors can result in a severe (potentially fatal) drug interaction. Refrain from using other MAO inhibitors listed below while undergoing treatment with Uribel: 

  • Isocarboxazid  
  • Linezolid 
  • Metaxalone 
  • Moclobemide 
  • Phenelzine 
  • Procarbazine  
  • Rasagiline 
  • Safinamide  
  • Selegiline 
  • Tranylcypromine

Moreover, abstain from taking most MAO inhibitors for two weeks before and after treatment with this medication. Consult your doctor regarding the appropriate timing for commencing or discontinuing this medication. 

Co-administration of Uribel with any other drugs that could enhance the likelihood of experiencing severely elevated blood pressure is contraindicated. Such drugs encompass: 

  • Herbal products like ephedra ma huang 
  • Nasal decongestants such as: phenylephrine and pseudoephedrine 
  • Stimulants such as: amphetamines, ephedrine, and epinephrine 
  • Diet aids  

Ensure a minimum 2-hour interval between taking Uribel and azole antifungal drugs (e.g., itraconazole, ketoconazole). 

Do not consume antacids or anti-diarrhea medication within one hour before or after taking Uribel, as they can hinder the absorption of hyoscyamine by your body. 

If you are also prescribed ketoconazole (Nizoral), ensure a time gap of at least 2 hours between taking it and Uribel. 

Caffeine may heighten the side effects of Uribel. Refrain from consuming substantial quantities of caffeine-containing beverages (e.g., coffee, tea, colas), excessive chocolate, or over-the-counter products with caffeine while taking this medication. 

Uribel contains salicylate, akin to aspirin. Children and adolescents under 18 years should not use aspirin or aspirin-related medications if they have chickenpox, the flu, an undiagnosed ailment, or have received a live virus vaccine (e.g., nasal flu or varicella vaccine) without prior consultation with a physician, as it may lead to a rare, yet severe condition called Reye’s syndrome. 

Carefully read the labels of all prescription and nonprescription medicines, as many of them contain pain relievers and fever reducers like aspirin, ibuprofen, ketorolac, or naproxen. These medications are similar to salicylate and may increase the risk of side effects if taken together.  

However, if your doctor has advised you to take low-dose aspirin (usually 81-162 milligrams a day) to prevent heart attack or stroke, you should continue taking it unless instructed otherwise. 

Ensure to review the labels of all your medications, including allergy or cough-and-cold products, as they might contain drowsiness-inducing ingredients. Seek guidance from your pharmacist regarding the safe usage of such products. 

Inform your healthcare provider or pharmacist if you are using other substances that induce drowsiness, including: 

  • Alcohol 
  • Marijuana (cannabis) 
  • Antihistamines (like cetirizine, diphenhydramine) 
  • Medications for sleep or anxiety (such as alprazolam, diazepam, zolpidem) 
  • Muscle relaxants 
  • Opioid pain relievers (such as codeine) 

The usage of Uribel might affect particular laboratory examinations, leading to erroneous test outcomes. Communicate your drug intake to laboratory personnel and healthcare providers. 

Uribel can reduce sweating and increase the risk of heat stroke. Avoid overheating by staying hydrated, dressing lightly, and resting in a cool place. Seek medical help for persistent fever, mood changes, headache, or dizziness. 

Uribel may have a greater impact on older adults regarding side effects such as confusion, agitation, drowsiness, unusual excitement, constipation, and difficulty urinating. The risk of falling is heightened due to the potential for increased confusion and drowsiness. 

The potential harm of Uribel to an unborn baby is uncertain. Inform your doctor about your pregnancy status or intention to conceive while taking this medicine. 

Methenamine and small amounts of hyoscyamine are present in breast milk and could potentially harm a nursing baby. Seek guidance from your healthcare provider before breastfeeding. 

Additional information

Generic name:

Methenamine/Methylene blue/ Sodium Phosphate Monobasic/Phenyl Salicylate/Hyoscyamine





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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Uribel (Methenamine/Methylene blue/ Sodium Phosphate Monobasic/Phenyl Salicylate/Hyoscyamine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Uribel (Methenamine/Methylene blue/ Sodium Phosphate Monobasic/Phenyl Salicylate/Hyoscyamine).