Aceon Plus (Perindopril/indapamide) Medication


Aceon Plus (Perindopril/indapamide)

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Drug Description


Aceon Plus is a medication that combines two active ingredients: Perindopril and Indapamide. Perindopril is an angiotensin-converting enzyme (ACE) inhibitor, while Indapamide is a diuretic. The combination of these two drugs is used to treat high blood pressure (hypertension). 

Perindopril works by relaxing and widening blood vessels, which helps to lower blood pressure. Indapamide helps to remove excess fluid from the body through increased urine production, further assisting in reducing blood pressure. 

Use and Dosage 

Aceon Plus should be taken exactly as directed by your healthcare provider, usually once a day. It is typically taken with a full glass of water, with or without food. The tablet should be swallowed whole, as chewing it may cause the medication to be released too quickly, increasing the risk of side effects. 

The recommended initial daily dosage for patients with essential hypertension is 4 mg of perindopril erbumine and 1.25 mg of indapamide. However, the actual dosage may be adjusted by your healthcare provider based on your medical condition and response to treatment. 

Take Aceon Plus regularly to get the maximum benefit from the medication. If you miss a dose, take it as soon as you remember, but do not take two doses at once to make up for the missed dose.  

Side Effects 

Common Side Effects  

  • Dizziness 
  • Headache 
  • Cough 
  • Fatigue 
  • Stomach upset 
  • Body aches or pain 
  • Chills 

Serious Side Effects 

  • Chest pain or tightness 
  • Decreased kidney function or kidney failure 
  • Decreased urination 
  • Difficulty breathing 
  • Dizziness 
  • Dry mouth 
  • Fainting 
  • Hepatitis or liver failure 
  • Hives 
  • Increased thirst, or weakness 
  • Inflammation of the pancreas 
  • Lightheadedness 
  • Low levels of potassium  
  • Sodium in the blood 
  • Swelling of the face, lips, tongue, or throat 
  • Yellowing of the skin or eyes 


  • Pregnancy: Aceon Plus can cause harm to an unborn baby if used during pregnancy. Prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking Aceon Plus. If you are planning pregnancy, become pregnant, or think you may be pregnant, inform your doctor immediately. 
  • Liver problems: Aceon Plus may cause liver damage in rare cases. If you experience symptoms such as yellowing of the skin or eyes, dark urine, or persistent nausea and vomiting, seek medical attention promptly. 
  • Low white blood cell count: Aceon Plus may rarely cause a decrease in white blood cell count (leukopenia), which can weaken the immune system. If you develop signs of infection, such as fever or persistent sore throat, notify your doctor. 
  • Itching (pruritus): Itching may occur as a side effect of Aceon Plus. If you experience severe or persistent itching, consult your doctor. 
  • Kidney problems: Aceon Plus can affect kidney function and may cause or worsen kidney problems. Your doctor may monitor your kidney function regularly while you are taking this medication. 
  • Hypotension (low blood pressure): Aceon Plus can cause a drop in blood pressure, especially when starting the medication or increasing the dosage. This can lead to symptoms such as dizziness or lightheadedness. Get up slowly from a sitting or lying position to minimize the risk of falls. 
  • Hyperkalemia (high potassium levels): Aceon Plus may increase potassium levels in the blood. This can be of concern for individuals with pre-existing kidney problems or those taking other medications that can raise potassium levels. Regular monitoring of potassium levels may be necessary. 
  • Angioedema: Rarely, Aceon Plus can cause a serious allergic reaction known as angioedema, which involves swelling of the face, lips, tongue, or throat. Seek immediate medical attention if you experience any signs of angioedema. 
  • Interactions with other medications: Aceon Plus may interact with other medications you are taking, including non-prescription medications and herbal supplements.  
  • Special populations: Aceon Plus may require special caution or dosage adjustments in certain populations, such as the elderly, those with liver or kidney problems, or individuals with certain medical conditions. Your doctor will assess your individual situation and determine the appropriate course of treatment.  

Additional information

Generic name:





2/6.25mg, 4/1.25mg

Quantities Available:

30, 90

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Aceon Plus (Perindopril/indapamide). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Aceon Plus (Perindopril/indapamide).