Indications 

Amitiza is a medication that facilitates bowel movements by augmenting fluid secretion in the intestines.  

This medication is indicated for treating chronic constipation, or constipation induced by opioid (narcotic) analgesics. Amitiza may be employed for managing irritable bowel syndrome in females presenting with constipation as the principal symptom. 

Uses and Dosage 

For patients taking Amitiza, generally administered twice a day. Follow all instructions on the prescription label and carefully read all medication guides or instruction sheets. 

Amitiza should be taken with food and water, and the capsule must be swallowed whole without crushing, chewing, breaking, or opening it. 

Within one hour of taking Amitiza, patients may experience chest tightness or shortness of breath. Although this side effect usually goes away within three hours, it may occur again with the next dose. Patients are advised to contact their physician if this side effect becomes bothersome. 

Patients with severe diarrhea should avoid taking Amitiza and should contact their doctor for further instructions. 

Regular progress checks with a healthcare provider are necessary while taking this medication. Amitiza should be stored at room temperature, away from heat and light. 

Side Effects 

Allergic Reactions

Seek immediate medical assistance if you experience any symptoms of an allergic reaction to Amitiza, such as: 

• Hives 
• Breathing difficulties 
• Swelling of the face, lips, tongue, or throat 

Severe Side Effects

Contact your doctor immediately if you have any of the following: 

• Persistent or severe nausea or diarrhea 
• Difficulty breathing 
• A feeling of dizziness or fainting 

Amitiza may cause a drop in blood pressure, resulting in fainting or dizziness, especially if you have been experiencing vomiting or diarrhea. If you experience lightheadedness after every dose or severe diarrhea, stop using Amitiza and seek medical attention. 

Common Side Effects  

• Nausea 
• Stomach pain 
• Diarrhea 
• Gas or bloating 
• Headache 

Caution 

Prior to taking lubiprostone, inform your healthcare provider or pharmacist of any allergies you may have to this medication or any of its inactive ingredients. Consult your pharmacist for additional information regarding inactive ingredients that may cause an allergic reaction or other complications. 

Before starting this medication, provide your doctor or pharmacist with your medical history, especially if you have a history of severe diarrhea, intestinal or stomach problems, or liver disease. 

If you are scheduled for surgery or dental work, ensure that your healthcare provider is aware of all the medications you are currently taking, including prescription medications, non-prescription medications, and herbal supplements. 

If you are pregnant, this medication should only be taken when needed. Discuss the potential risks and benefits of using lubiprostone during pregnancy with your doctor.