Indications 

Apoquel is a pharmaceutical preparation intended for the treatment of allergy-related symptoms such as itching and inflammation in dogs.  

It works by selectively inhibiting a crucial itch signal within a dog’s body, thereby preventing the onset of pruritus. Apoquel exhibits a rapid onset of action, with notable improvements in itching within 24 hours of administration.  

Veterinarians may recommend short-term usage of Apoquel® for the management of allergic flare-ups or long-term administration for the management of skin allergies. 

Uses and Dosage 

In administering Apoquel, adhere to the guidelines on the label as well as those provided by your veterinarian. The tablets are intended for oral administration, and can be given with or without food.  

If your dog experiences vomiting after taking the medication, kindly consult with your veterinarian before administering it with a meal or food. 

Apoquel is specifically authorized for use in canines of 12 months and above, and must not be used in pregnant, nursing, or breeding dogs. In addition, notify your veterinarian of any serious infections in your dog, as this medication is contraindicated in such cases. 

Inform your veterinarian of all medications and supplements currently being taken by your dog, and avoid administering additional medications without prior consultation. Notably, the compatibility of Apoquel with certain common allergy medications such as steroids and cyclosporine (Atopica) is currently unknown. 

Side Effects 

Common Side Effects

The most common side effects associated with the use of Apoquel are as follows: 

• Vomiting 
• Diarrhea 
• Anorexia 
• Decreased energy (lethargy) 
• Increased thirst 

Usually, these side effects are self-limiting and resolve spontaneously. However, in the event that the side effects persist or are severe, contact your veterinarian. 

Severe Side Effects

Take note that more serious side effects may occur, which include: 

• Serious infections, such as:
  • Pneumonia
  • Urinary tract infections
  • Skin infections
• Demodicosis (a skin disease caused by Demodex mites) 
• Skin masses, including cysts between the toes and skin cancer 
• Cancer (new tumors or worsening of existing ones) 
• Aggression 
• Low white blood cell count 

Monitor your dog for any signs of infections, skin changes, or cancer development in consultation with your veterinarian. Contact your veterinarian immediately if you observe any of the following: 

• Trouble breathing 
• Decreased energy or listlessness 
• Any skin or haircoat changes 
• New masses or changes to existing ones 
• Fever 
• Changes in urination (including accidents, frequency of urination, and bloody urine) 

Caution 

APOQUEL is contraindicated for use in canines that are less than 12 months of age. APOQUEL exerts its therapeutic effect by modulating the immune system. APOQUEL should not be used in dogs with serious infections, and may increase the susceptibility to infection, including demodicosis, and exacerbation of neoplastic conditions 

Dogs treated with APOQUEL during clinical studies exhibited new neoplastic conditions (both benign and malignant), which have been reported in the post-approval period. 

Before administering APOQUEL, weigh the risks and benefits of treatment in canines with a history of recurrent serious infections, recurrent demodicosis, or neoplasia.  

To prevent accidental ingestion or overdose, store APOQUEL securely in a location that is inaccessible to dogs, cats, and other animals.