Indications 

Boniva is a bisphosphonate medication that modifies the natural process of bone formation and breakdown in the body. By doing so, it can slow down bone loss and potentially reduce the likelihood of bone fractures. 

This prescription medication is primarily used to treat or prevent osteoporosis in postmenopausal women. Its active ingredient, ibandronate, has been shown to increase bone mass and lower the risk of spinal fractures. 

The duration of Boniva’s effectiveness for treating and preventing osteoporosis is currently unknown. Therefore, consult with your doctor to assess if this medication is still the appropriate course of treatment for your condition. 

Uses and Dosage 

Before starting this medication and each time you refill it, be sure to read the Medication Guide and, if available, the Patient Information Leaflet, as new information may become available. To ensure you absorb as much of the drug as possible and reduce the risk of injury to your esophagus, follow the instructions provided. If you have any questions, consult your doctor or pharmacist. 

This medication should be taken orally, as directed by your doctor, usually once a month on the same day each month. Select the day of the month that best fits your schedule. Take the medication after rising for the day and at least 60 minutes before consuming any food, beverage, or other medication. Do not ingest it at bedtime or while still in bed. 

Consume this medication with a full glass (6 to 8 ounces/180 to 240 milliliters) of plain water. Do not take it with any other beverages. Do not chew, suck, or keep the tablet in your mouth to melt; swallow the tablet whole. Remain fully upright (sitting, standing, or walking) for at least 60 minutes, and do not recline until after your first meal of the day. Wait at least 60 minutes after taking ibandronate before consuming or drinking anything except plain water and before taking any other medication orally. 

Certain medications, such as quinapril, certain forms of didanosine (chewable/dispersible buffered tablets or pediatric oral solution), sucralfate, and bismuth subsalicylate, may interfere with the absorption of ibandronate. Calcium or iron supplements, vitamins with minerals, and antacids containing calcium, magnesium, or aluminum, as well as foods such as dairy products (such as milk, yogurt), mineral water, and calcium-enriched juice, may interfere with absorption. Refrain from taking these products for at least 60 minutes after taking ibandronate. 

To obtain the most benefit from this medication, take it regularly. Remember to take it on the same day each month, and marking your calendar with a reminder may be helpful. Discuss the risks and advantages of using this medication for an extended period with your doctor. 

Do not discontinue taking any other medications prescribed for your condition unless directed to do so by your doctor. 

Side Effects 

Allergic Reactions 

• Hives 
• Wheezing, difficult breathing 
• Swelling of your face, lips, tongue, or throat 

Severe Side Effects

Stop using this medicine and call your doctor at once if you have: 

• Chest pain, new or worsening heartburn 
• Difficulty or pain when swallowing 
• Pain or burning under the ribs or in the back 
• Severe heartburn, burning pain in your upper stomach, or coughing up blood 
• New or unusual pain in your thigh or hip 
• Jaw pain, numbness, or swelling 
• Severe joint, bone, or muscle pain 
• Low calcium levels:
  • muscle spasms or contractions
  • numbness or tingly feeling (around your mouth, or in your fingers and toes) 

Common Side Effects 

• Heartburn, stomach pain, diarrhea 
• Back pain, bone pain, muscle or joint pain 
• Pain in your arms or legs 
• Headache 
• Fever, chills, tiredness, flu-like symptoms 

Cautions  

Before using Boniva, make sure to inform your doctor if you have severe kidney disease or low levels of calcium in your blood as this medication may not be suitable for you. 

Do not take Boniva if you have difficulty swallowing, problems with your esophagus, or if you are unable to sit upright or stand for at least 60 minutes after taking the tablet. These conditions may increase the risk of serious stomach or esophagus problems associated with Boniva. 

If you experience chest pain, new or worsening heartburn, or pain when swallowing, stop taking Boniva immediately and contact your doctor right away. You should seek medical attention if you have muscle spasms, numbness or tingling in your hands and feet or around the mouth, new or unusual hip pain, or severe pain in your joints, bones, or muscles, as these could be signs of serious side effects associated with the medication.