Colazal (Balsalazide) Medication


Colazal (Balsalazide)

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Table of contents:

Drug Description


Colazal is a prescribed medication for treating mild to moderately active ulcerative colitis in adults and children aged 5 and above. This condition is characterized by inflammation and sores in the lining of the colon and rectum. 

As an aminosalicylate drug, Colazal works to reduce bowel inflammation, diarrhea, rectal bleeding, and stomach pain associated with the condition. 

Uses and Dosage 

Before taking Colazal and with each prescription refill, thoroughly review its medication guide and patient information leaflet. Ask your doctor or pharmacist if you have any questions or concerns. 

Colazal dosage is determined based on the patient’s age, medical condition, and response to the treatment. 

Typically, this medication is taken three times a day as prescribed by the doctor, without regard to food intake.  

Colazal capsules can be taken whole or opened and mixed with applesauce for easier swallowing. The mixture should be consumed immediately and not stored for future use. If necessary, the mixture can be chewed. 

For the best results, take Colazal regularly at the same time(s) each day. Avoid taking more or less than the prescribed dosage or more frequently than your doctor instructed. 

Inform your doctor if your condition does not improve or worsens. 

Side Effects 

Listed below are the potential adverse effects that may arise from taking Colazal. If any of them last or worsen, inform your doctor promptly. 

Common Side Effects 

  • Headache 
  • Mild or occasional nausea, vomiting, stomach pain, or diarrhea 
  • Joint pain 
  • Fever 
  • Cold symptoms: 
    • Stuffy nose 
    • Sneezing 
    • Sore throat 

Serious Side Effects 

  • Pain or burning during urination 
  • Worsening colitis symptoms:  
    • Fever 
    • Stomach pain 
    • Cramps 
    • Bloody diarrhea 
  • Signs of kidney problems: 
    • Decreased or no urination 
    • Swelling 
    • Rapid weight gain 
  • Signs of liver problems: 
    • Upper stomach pain 
    • Loss of appetite 
    • Dark urine 
    • Clay-colored stools 
    • Jaundice (yellowing of skin or eyes) 
  • Indication of low red blood cells (anemia): 
    • Pale skin 
    • Unusual fatigue 
    • Lightheadedness 
    • Shortness of breath 
    • Cold hands and feet 

Call your doctor immediately if you experience any of the above-listed severe side effects. 

Allergic Reactions 

Severe allergic reactions to Colazal are uncommon; however, seek immediate medical attention if you experience symptoms such as: 

  • Rash 
  • Itching/swelling, especially of the face, tongue, or throat 
  • Severe dizziness 
  • Trouble breathing 

This list does not contain all the potential side effects of Colazal. If you encounter any unlisted effects, tell your doctor promptly. 


Before starting treatment with Colazal, inform your doctor and pharmacist if you have any known hypersensitivities, especially to: 

  • Balsalazide 
  • Other aminosalicylates (e.g., mesalamine or olsalazine) 
  • Salicylates (e.g., aspirin or salsalate) 
  • Sulfasalazine 
  • Any other medications 
  • Any of the ingredients present in Colazal capsules 

To ensure Colazal is safe for you, disclose to your physician your medical background, specifically if you have a history of: 

  • Pyloric stenosis (stomach/intestinal condition) 
  • Liver disease 
  • Kidney disease  

Some medicines may interact with Colazal, including dichlorphenamide. To minimize such drug interactions, inform your doctor and pharmacist about all your medications, including prescription and over-the-counter drugs, other dietary supplements, and herbal products. 

Balsalazide, the active ingredient of Colazal, closely resembles mesalamine. Refrain from taking oral mesalamine drugs during Colazal treatment. 

Colazal tablets contain sodium. If you are following a low-salt diet, consult your doctor before using this medication. 

Inform lab personnel and all physicians that you take Colazal, as it may disrupt specific lab tests (such as urine normetanephrine levels) and yield inaccurate results. 

Colazal can increase sensitivity to sunlight, particularly if you have skin conditions like atopic dermatitis or eczema. Limit sun exposure, avoid tanning booths and sunlamps, and take precautions such as using sunscreen and wearing protective clothing when outdoors. In case of sunburn or skin blisters/redness, promptly inform your doctor. 

During pregnancy, the use of Colazal should be limited to situations where it is clearly necessary. Discuss thoroughly with your doctor the risks and benefits of using the medication. 

The excretion of balsalazide in human milk is unknown. Consult with your doctor before breastfeeding while taking this medication. 

Additional information

Generic name:



Capsule, Tablet



Quantities Available:

100, 130

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Colazal (Balsalazide). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Colazal (Balsalazide).