Coly-Mycin M (Colistimethate) Medication


Coly-Mycin M (Colistimethate)

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Generic Alternative - Coly-Mycin M (Colistimethate)

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Table of contents:

Drug Description


Coly-Mycin M is indicated for the treatment of certain bacterial infections. 

Coly-Mycin M belongs to the class of antibiotics and functions by eradicating bacteria. 

Uses and Dosage 

Coly-Mycin M is supplied in powder form inside a vial and should be reconstituted with 2 mL sterile water for intramuscular injection or intravenous infusion.  

If instructed, you may receive training on self-administering injections at home. Do not self-administer this medication unless you are fully aware of the proper mixing and storage methods, as well as the injection technique and safe disposal of needles, IV tubing, and related items. 

Before administering Coly-Mycin M and every time you refill your prescription, carefully read the accompanying medication guide and patient information leaflet. Should any concerns or questions arise, seek guidance from your doctor or pharmacist. 

The prescribed dosage and duration of your treatment with this medication are determined by your overall health, the specific infection you have, and your response to the medication. 

Typically, Coly-Mycin M is administered every 6 to 12 hours. It can be given via intramuscular injection in the buttocks or thighs, intravenous injection over 3 to 5 minutes, or continuous intravenous infusion lasting 22 to 23 hours. 

When reconstituting Coly-Mycin M, gently swirl it to prevent foaming.  

Before administration, visually examine the solution for any particulate matter or discoloration. If either of these issues is detected, do not use the solution. 

Following the preparation of Coly-Mycin M for intravenous infusion, it must be administered immediately and should not be stored for future use. 

For intramuscular injection, you can store the mixture in a refrigerator or at a cool room temperature but avoid freezing it. Ensure usage within 7 days. 

Adhere to the complete prescribed course of Coly-Mycin M as directed to achieve optimal results. Although symptoms may improve before the infection is fully eradicated, skipping doses can heighten the likelihood of developing antibiotic-resistant infections. 

Store unprepared Coly-Mycin M at a cool room temperature, shielding it from moisture and heat. 

Side Effects 

The potential adverse effects of Coly-Mycin M are outlined below. Promptly tell your doctor if any of these symptoms persist or worsen. 

Common Side Effects 

  • Numbness or tingling in hands, feet, mouth, or tongue 
  • Slurred speech 
  • Dizziness or spinning sensation 
  • Itching or mild rash 
  • Upset stomach 

Serious Side Effects 

  • Intense abdominal pain, watery or bloody diarrhea 
  • Seizures 
  • Slow breathing 
  • Unusual muscle weakness 
  • Fever 
  • Kidney issues:  
    • Reduced or no urination 
    • Painful or difficult urination 
    • Swelling in feet or ankles, fatigue 
    • Shortness of breath 

Contact your doctor right away if any of the severe symptoms above occur. 

Allergic Reactions 

In rare cases, Coly-Mycin M may trigger a severe allergic response. Immediate medical aid is needed if you observe signs of an allergic reaction, such as: 

  • Hives 
  • Itching 
  • Breathing difficulties 
  • Swelling of the mouth, face, lips, tongue, or throat 

This list does not cover all side effects of Coly-Mycin M. Report any other symptoms you may observe to your doctor. 


Before starting treatment with Coly-Mycin M, inform your doctor if you have any known allergies, particularly to: 

  • Colistimethate  
  • Polymyxin B  
  • Colistin  
  • Any inactive ingredients within the medication 

Seek advice from your doctor before administering Coly-Mycin M if you have a history of kidney disease or conditions affecting nerves and muscles, like myasthenia gravis. 

Coly-Mycin M may interact with cephalothin. To reduce the potential of such interactions, disclose all your current medications, including prescriptions, over-the-counter drugs, vitamins, and herbal products, to your doctor. 

Coly-Mycin M injection may induce dizziness or impair coordination. Refrain from driving or operating machinery until you are aware of how this medication may affect you. 

Inform your surgeon in advance if you require surgery while using Coly Mycin M. Temporary discontinuation of the medication may be necessary. 

Coly Mycin M may diminish the effectiveness of live bacterial vaccines (e.g., typhoid vaccine). Inform your healthcare provider of your medication use before receiving any immunizations or vaccinations. 

The impact of Coly-Mycin M on the development of an unborn baby remains uncertain. Notify your doctor about your pregnancy status or intentions to conceive before starting treatment with Coly-Mycin M. 

The transfer of colistimethate into breast milk and its effects on the nursing baby remains uncertain. Disclose your breastfeeding status to your doctor before administering this medication. 

Additional information

Generic name:

Colistimethate, colistimethate





Quantities Available:

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Coly-Mycin M (Colistimethate). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Coly-Mycin M (Colistimethate).