Indications 

Cuprimine is a medication commonly used for the treatment of liver disease in dogs and cats. It is also known by its generic name, penicillamine. Cuprimine is a chelating agent, which means it helps remove heavy metals from the body. In the case of liver disease, Cuprimine is often used to remove excess copper that can accumulate in the liver. 

Cuprimine is commonly used in the treatment of liver disease, such as copper storage disease (CSLD) in dogs and cats. CSLD is a condition where copper accumulates in the liver, leading to liver damage and dysfunction. By reducing copper levels, Cuprimine can help slow down the progression of liver disease and alleviate symptoms. 

Penicillamine works by acting as a chelating agent, which means it has the ability to bind to certain metals in the body, particularly copper. In the case of pets with liver disease, Cuprimine is often used to remove excess copper that can accumulate in the liver. 

Use and Dosage 

Cuprimine is available in the form of tablet which is typically prescribed by a veterinarian and should only be used under their guidance. The dosage and duration of treatment will depend on the specific condition being treated and the individual needs of the pet. 

Cuprimine tablets are usually given orally. You can either give the tablet directly to your pet or hide it in a treat or food to make it more appealing. If your pet is cooperative, you can place the tablet at the back of their tongue and gently hold their mouth closed until they swallow. Be careful to avoid pushing the tablet too far back, as it may cause discomfort. 

If your pet is not keen on taking tablets, you can try hiding the tablet in a small amount of food or a treat. Make sure the treat or food is something your pet enjoys and will readily eat. Some options include canned dog food, cooked sweet potato, or commercially available pill pockets designed to conceal medication. 

After administering the tablet, keep an eye on your pet to ensure they have swallowed it. Some pets may try to spit out the tablet or hide it in their mouth, so, observe them to ensure they have taken the medication. 

Side Effects 

Common Side Effects 

• Nausea 
• Vomiting 
• Loss of appetite 
• Diarrhea 
• Rash 
• Ringing in the ears 

Serious Side Effects  

• Bone marrow suppression 
• Kidney damage 
• Liver damage 
• Skin reactions, such as:
  • Rashes
  • Itching
  • Scaling

Cautions 

• Some pets may be allergic to penicillamine. If your pet has a known allergy to penicillamine or similar medications, inform your veterinarian. 
• Cuprimine can cause side effects in pets, including gastrointestinal upset such as vomiting or diarrhea. It may also lead to loss of appetite, lethargy, and allergic reactions. If you notice any unusual symptoms or side effects in your pet while using Cuprimine, contact your veterinarian. 
• Regular monitoring of your pet’s liver function, blood cell counts, and copper levels may be necessary during treatment with Cuprimine. This helps ensure that the medication is effectively managing the condition and that there are no adverse effects. Your veterinarian will advise you on the appropriate frequency of monitoring. 
• Cuprimine may interact with other medications your pet is taking. Inform your veterinarian about all medications, including over-the-counter supplements or herbal products that your pet is currently receiving. This will help prevent any potential interactions or adverse effects. 
• Cuprimine should be used with caution in pregnant or lactating animals. Discuss the potential risks and benefits with your veterinarian if you have a pregnant or lactating pet that requires treatment with Cuprimine. 
• Some pets may have individual sensitivities or allergies to Cuprimine or its components. If your pet has a known sensitivity or allergy to penicillamine or other medications, inform your veterinarian before starting Cuprimine treatment.