Differin Gel (Adapalene) Medication


Differin Gel (Adapalene)

Prescription Prescription Required
Buy Brand
Dosage Quantity Buy Now
0.10% Add To Cart

Generic Alternative - Differin Gel (Adapalene)

Prescription Prescription Required
Buy Adapalene
Dosage Quantity Buy Now
0.10% Add To Cart
5 Star Excellence award from Shopper Approved for collecting at least 100 5 star reviews



Differin Gel is a topical medication indicated for treating acne vulgaris, a common type of acne in adolescents and young adults, caused by hyperactive oil glands that become obstructed and inflamed in the skin. 

As a member of the retinoid family, Differin Gel operates by modifying cell growth and reducing swelling and inflammation. These actions reduce the quantity and intensity of acne lesions while expediting the healing process of existing lesions. 

Differin Gel exhibits vitamin A-like properties that facilitate the regulation of cell turnover, promoting a healthier skin environment. By controlling cell turnover, these compounds prevent pore blockages and proactively address acne before it develops. 

Uses and Dosage 

Before using Differin Gel, and every time you get a refill, thoroughly review its patient information leaflet and medication guide. Consult a healthcare provider for any questions or clarifications. 

Differin Gel is usually applied to the face once daily at bedtime. For proper application: 

  • Wash hands before applying the gel 
  • Gently clean the affected skin with a mild cleanser 
  • Dry the skin with a clean towel 
  • Apply a thin layer to the affected areas (avoid contact with eyes, lips, and mucous membranes) 

Follow the precise instructions on the when applying Differin Gel. Refrain from using excessive amounts or frequency beyond the prescribed dosage by your doctor or indicated on the packaging. Overusing this gel will not expedite or enhance outcomes but could result in skin irritation. 

Tell your doctor if your skin becomes dry while using Differin Gel. A skin moisturizer may be recommended to help with dryness, or you may be advised to apply the gel less often. 

Use Differin Gel regularly at the same time of the day. You may experience an initial exacerbation of acne during the first few weeks of treatment, and it could take up to 8 to 12 weeks or more to see the full benefits of it.  

To ensure optimal storage conditions, keep Differin Gel at room temperature, and protect it from moisture and heat. Avoid freezing the product. 

Side Effects 

Potential adverse reactions associated with Differin Gel are listed below. If any of them persists or worsens, promptly inform your physician or pharmacist. 

Common Side Effects 

  • Dry, red, or scaly skin 
  • A sensation of warmth and mild stinging or burning 
  • Peeling skin 
  • Skin pain 

Serious Side Effects 

  • Skin redness, stinging, burning, or peeling after exposure to the sun 

Stop using this gel and call your doctor immediately if you experience these severe side effects. 

Allergic Reactions 

Instances of severe allergic reactions to Differin Gel are infrequent: however, promptly seek medical attention if any indications of such a reaction manifest, such as:  

  • Rash 
  • Inflammation or itchiness (particularly in the face, tongue, or throat) 
  • Acute dizziness 
  • Breathing difficulties 

These adverse effects are not an exhaustive compilation of the potential side effects linked to Differin Gel. If you experience any unmentioned side effects, consult your doctor. 


Prior to utilizing Differin Gel, it is recommended to inform your physician or pharmacist of any known allergies to the medication, vitamin A-related drugs, such as isotretinoin, or any other allergies.  

This gel may contain inactive ingredients that could elicit allergic reactions or other adverse effects. For additional information, consult your pharmacist. 

Disclose to your doctor if you have had eczema or any other skin condition. 

Tell your doctor about your skin products, including soaps, cleansers, moisturizers, and cosmetics.  

Refrain from using skin products that can cause harshness, irritation, or dryness on the treated area. Such products may comprise hair perming solutions, astringents, toners, or shaving lotions that contain alcohol, lime, or menthol. 

You may be advised to stop using the following: 

  • Medicated or abrasive soaps and cleansers 
  • Soaps and cosmetics with potent drying effects, such as alpha hydroxy acids and glycolic acids 
  • Products that contain sulfur, resorcinol, or salicylic acid 

Differin Gel can make the skin sensitive to sunlight or ultraviolet light. Avoid unnecessary or prolonged exposure to natural and artificial sunlight (tanning beds and sunlamps) and wear protective clothing, sunglasses, and sunscreen, especially if you sunburn easily.  

Due to the potential risk of harm to a developing fetus, women who are pregnant or may become pregnant should refrain from handling this medication as it is absorbed through the skin. 

Differin Gel should be used during pregnancy only if the potential benefit outweighs the 

potential risk to the fetus. Tell your doctor if you are pregnant or plan to become pregnant while using this gel. 

It is not known whether adapalene can be passed into breast milk. Consult your doctor before nursing an infant while using this gel. 

Additional information

Generic name:






Quantities Available:


Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Differin Gel (Adapalene). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Differin Gel (Adapalene).