Divigel (Estradiol Gel) Medication


Divigel (Estradiol Gel)

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Drug Description


This pharmaceutical substance represents a form of the female hormone, specifically estrogen, which is readily assimilated through the dermal layers and subsequently enters the circulatory system. Its application is intended to assist women in alleviating a specific symptom associated with menopause, namely hot flashes. The manifestation of menopausal symptoms arises from the natural decline in endogenous estrogen production. In instances where estrogens are employed solely for the treatment of vaginal menopausal symptoms, such as dryness, burning, or itching, prioritize the utilization of locally administered vaginal products prior to resorting to oral, transdermal, or injectable medications. 

Uses and Dosage 

the use of estrogen and progestin medication in postmenopausal women. Estrogen is typically prescribed to women with a uterus, along with progestin to reduce the risk of endometrial cancer. However, women without a uterus do not need progestin, except in certain cases such as a history of endometriosis after a hysterectomy. 

apply the medication to a clean and dry upper thigh, following specific instructions from the doctor. The medication should only be applied by authorized individuals and should not be used on broken or irritated skin. After application, hands should be washed thoroughly to prevent inadvertent transmission of the drug. The application site should be allowed to dry before dressing, and appropriate clothing should be worn to cover the site. Others should avoid touching the area for at least one hour, and if accidental contact occurs, the affected area should be promptly cleaned with soap and water. 

Wait at least one hour before showering or swimming to ensure optimal absorption of the medication through the skin. 

Side Effects 

Common Side Effects

While taking this medication, it’s possible to experience certain side effects such as: 

  • Nausea/vomiting 
  • Bloating 
  • Breast tenderness 
  • Headache 
  • Weight changes  

If any of these effects persist or worsen, inform your doctor or pharmacist. 

Keep in mind that your doctor has prescribed this medication because they have determined that the benefits outweigh the potential risks of side effects. Note that many individuals who use this medication do not experience serious side effects. 

Severe Side Effects

However, if you encounter any severe side effects, notify your doctor immediately. These may include:  

  • Persistent nausea/vomiting 
  • Changes in mental/mood such as:  
    • Depression 
    • Memory loss 
  • Presence of breast lumps 
  • Unusual vaginal bleeding such as:  
    • Spotting 
    • Breakthrough bleeding 
    • Prolonged/recurrent bleeding 
  • Increased or new vaginal irritation/itching/odor/discharge 
  • Severe stomach/abdominal pain 
  • Yellowing of the eyes or skin 
  • Dark urine 
  • Swelling of the hands/ankles/feet 
  • Increased thirst/urination 


Prior to initiating the use of this medication, disclose your medical history to your doctor or pharmacist, particularly regarding the following conditions:  

  • Vaginal bleeding of unknown origin 
  • Specific cancers such as:  
    • Breast cancer 
    • Uterine/ovarian cancer 
  • Blood clotting disorders 
  • History of blood clots or stroke 
  • Heart disease (including heart attack) 
  • Liver disease 
  • Kidney disease 
  • Family medical history especially concerning:  
    • Breast lumps 
    • Cancer 
    • Blood clots 
  • Personal or family history of angioedema (a certain swelling disorder) 
  • Clotting disorders such as:  
    • Protein C 
    • Protein S deficiency 
  • Hypertension (high blood pressure) 
  • Diabetes 
  • High cholesterol/triglyceride levels 
  • Obesity 
  • Lupus 
  • Hypothyroidism (underactive thyroid) 
  • Mineral imbalances (low or high blood calcium levels) 
  • Hypoparathyroidism (a specific hormone problem) 
  • Uterine issues such as:  
    • Fibroids 
    • Endometriosis 
  • Gallbladder disease 
  • Asthma 
  • Seizures 
  • Migraine headaches 
  • Mental/mood disorders such as:  
    • Dementia 
    • Depression 
  • Certain blood disorders (porphyria) 

Additional information

Generic name:

Estradiol Gel


Gel Sachet


0.5mg, 0.25mg, 1mg

Quantities Available:

30 sachets, 90 sachets

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Divigel (Estradiol Gel). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Divigel (Estradiol Gel).