Edarbyclor (Azilsartan Medoxomil/Chlorthalidone) Medication


Edarbyclor (Azilsartan Medoxomil/Chlorthalidone)

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Generic Alternative - Edarbyclor (Azilsartan Medoxomil/Chlorthalidone)

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Table of contents:

Drug Description


Edarbyclor is a pharmacological preparation consisting of a synergistic blend of azilsartan and chlorthalidone. Azilsartan, classified as an angiotensin II receptor blocker (commonly known as an ARB), functions by selectively blocking the angiotensin II receptor, thereby inhibiting its vasoconstrictor and aldosterone-secreting effects. 

Chlorthalidone, on the other hand, is classified as a thiazide diuretic, acting as a potent water pill to impede excessive salt absorption by the body, consequently mitigating fluid retention. 

Edarbyclor finds its application in the management of hypertension, as it contributes to the reduction of blood pressure levels. This effect, in turn, aids in diminishing the likelihood of stroke or myocardial infarction occurrence. 

Uses and Dosage 

The typical adult dosage for hypertension is as follows: 

  • Initial dosage: Administer orally once daily, containing Azilsartan 40 mg and Chlorthalidone 12.5 mg. 
  • Maximum dosage: Administer orally once daily, containing Azilsartan 40 mg and Chlorthalidone 25 mg. 

If necessary to attain the desired blood pressure target, the dosage may be escalated after a duration of 2 to 4 weeks. 

Edarbyclor can be taken with or without food. 

Regular monitoring of blood pressure is essential, and it may be necessary to assess kidney function periodically. 

The use of this medication may result in significantly low blood pressure. notify your doctor if you experience symptoms such as vomiting, diarrhea, or excessive sweating. 

Continue using this medication as prescribed, even if you feel in good health. Hypertension frequently exhibits no noticeable symptoms, and you may require lifelong treatment with blood pressure medication. 

Side Effects 

Severe Side Effects

Promptly contact your healthcare provider if you experience any of the following symptoms while taking Edarbyclor: 

  • Sensation of fainting or lightheadedness 
  • Reduced or no urination 
  • Swelling, weight gain, or a sensation of breathlessness 
  • Indications of an electrolyte imbalance, such as:  
    • Dry mouth 
    • Excessive thirst 
    • Weakness 
    • Drowsiness 
    • Restlessness 
    • Confusion 
    • Increased or decreased urination 
    • Nausea 
    • Vomiting 
    • Constipation 
    • Muscle discomfort or weakness 
    • Rapid heart rate 
    • Seizures (convulsions) 

Common Side Effects

Common side effects of Edarbyclor may include: 

  • Dizziness 
  • Fatigue 

This is not an exhaustive list of potential side effects, and there may be others. If you encounter any unusual symptoms, please consult your healthcare provider. 


Edarbyclor should not be utilized if you have a known allergy to azilsartan or chlorthalidone, or if you have a condition that hinders urination. 

If you have diabetes, avoid the concomitant use of Edarbyclor with any medication containing Aliskiren, which is a blood pressure medicine. 

If you have kidney disease, caution should be exercised when considering the use of Edarbyclor with an aliskiren. 

To ensure the safety of Edarbyclor, inform your doctor about the following medical conditions: 

  • Liver or kidney disease 
  • Gout 
  • Electrolyte imbalance (such as low levels of potassium in the blood) 
  • History of heart disease or stroke 
  • Dehydration 

Edarbyclor must not be used during pregnancy. If you become pregnant while using the medication, discontinue its use and promptly inform your doctor. 

Additional information

Generic name:

Azilsartan Medoxomil/Chlorthalidone




40/12.5mg, 40/25mg

Quantities Available:

84, 100

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Edarbyclor (Azilsartan Medoxomil/Chlorthalidone). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Edarbyclor (Azilsartan Medoxomil/Chlorthalidone).