Estrace (Estradiol) Medication


Estrace (Estradiol)

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Estrace is a prescription medicine indicated for the treatment of: 

  • Moderate to severe vasomotor symptoms associated with menopause. 
  • Moderate to severe symptoms of vulvar and vaginal atrophy associated with menopause. Topical vaginal products should be considered when prescribing solely for this purpose. 
  • Hypoestrogenism caused by conditions such as hypogonadism, castration, or primary ovarian failure. 
  • Breast cancer (palliation only) in appropriately selected women and men with metastatic disease. 
  • Advanced androgen-dependent carcinoma of the prostate (palliation only). 
  • Osteoporosis prevention in women at significant risk for whom non-estrogen medications are not appropriate (therapy should only be considered for this purpose). 

Belonging to the class of drugs called estrogen derivatives, Estrace works by replenishing the estrogen hormone that is typically synthesized by the body aiding in regulating many processes in the body. 

Uses and Dosage 

Before starting treatment with Estrace and every time you get a refill, carefully read its patient information leaflet and medication guide. Consult with your physician or pharmacist to address any questions and concerns. 

The dosage of Estrace may vary depending on the individual’s medical condition and response to treatment. Adhere to the prescribed instructions for taking Estrace and avoid altering the dosage or frequency of administration without medical guidance. 

Typically, Estrace is taken once a day as directed by the doctor without regard to food. However, in case of stomach upset, it may be necessary to take Estrace with a meal. 

To achieve optimal results, take Estrace regularly at the same time(s) of the day every day. Do not stop taking this medication without the advice of your physician, doing so might lead to a deterioration of the situation. 

Side Effects 

Potential adverse reactions associated with the use of Estrace are listed below. If any of these symptoms persist or worsen, promptly notify your physician. 

Common Side Effects 

  • Gastrointestinal symptoms such as: 
    • Nausea 
    • Vomiting 
    • Diarrhea 
    • Stomach cramps 
  • Cold symptoms such: 
    • Stuffy nose 
    • Sinus pain 
    • Sore throat 
  • Changes in mood and sleep patterns, including insomnia 
  • Weight gain 
  • Headache and back pain 
  • Breast pain 
  • Thinning scalp hair 
  • Vaginal itching or discharge, alterations in menstrual periods, and breakthrough bleeding 

Serious Side Effects 

  • Symptoms of a heart attack, including: 
    • Chest pain or pressure 
    • Pain spreading to the jaw or shoulder 
    • Nausea 
    • Sweating 
  • Signs of a stroke, such as: 
    • Sudden numbness or weakness (particularly on one side of the body), 
    • Sudden severe headache 
    • Slurred speech 
    • Problems with vision or balance 
  • Signs of a blood clot, including: 
    • Sudden vision loss 
    • Stabbing chest pain 
    • Feeling short of breath 
    • Coughing up blood 
    • Pain or warmth in one or both legs 
  • Cognitive impairments such as: 
    • Memory problems 
    • Confusion 
    • Unusual behavior 
  • Elevated calcium levels in the blood, with symptoms such as: 
    • Nausea 
    • Vomiting 
    • Constipation 
    • Increased thirst or urination 
    • Muscle weakness 
    • Bone pain 
    • Fatigue 
  • Unusual vaginal bleeding or pelvic pain 
  • Swelling or tenderness in the abdomen 
  • Jaundice (yellowing of the skin or eyes) 
  • A lump in the breast 

Call your doctor right away if any of the severe symptoms listed above occur. 

Allergic Reactions 

Immediate medical assistance must be sought in the event of displaying signs of an allergic reaction to Estrace, including: 

  • Hives 
  • Difficult breathing 
  • Swelling or itching of the face, lips, tongue, or throat 

This list of adverse effects here does not include all side effects associated with the use of Estrace. If any bothersome adverse effects not mentioned above are experienced, promptly notify your physician. 


Before taking Estrace, inform your healthcare provider or pharmacist if you have any known allergies, especially to estradiol. Inactive ingredients of this medication can trigger allergic reactions or other problems. Ask your pharmacist for more details. 

To ensure Estrace is safe for you, disclose your medical history to your doctor, especially of: 

  • Vaginal bleeding of unknown cause 
  • Certain cancers such as breast, uterus, or ovaries cancer 
  • Blood clots, stroke, or heart disease 
  • Liver or kidney disease 
  • Family history of breast lumps, cancer, or blood clots 
  • Family or personal history of a swelling disorder called angioedema 
  • Blood clotting disorders such as protein C or protein S deficiency 
  • High blood pressure, diabetes, high cholesterol/triglyceride levels, or obesity 
  • Lupus or underactive thyroid (hypothyroidism) 
  • Mineral imbalances such as low or high levels of calcium in the blood 
  • Hormone problems such as hypoparathyroidism 
  • Uterus problems such as fibroids or endometriosis 
  • Gallbladder disease, asthma, seizures, or migraine headaches 
  • Certain blood disorders such as porphyria 
  • Mental/mood disorders such as dementia or depression 

Certain medications may interact with Estrace including but not limited to: 

  • Aromatase inhibitors such as anastrozole, exemestane, letrozole 
  • Fulvestrant 
  • Ospemifene 
  • Raloxifene 
  • Tamoxifen 
  • Toremifene 
  • Tranexamic acid 

To avoid such drug interaction, tell your doctor and pharmacist about all the prescription and non-prescription medications, dietary supplements, vitamins, and herbal products you are presently using or planning to use. 

Estrace has the potential to disrupt specific laboratory examinations, such as the metyrapone test, which may result in misleading outcomes. Inform both laboratory staff and all medical professionals that you are taking this medication. 

Estrace has the potential to induce melasma, resulting in uneven and dark patches on the skin. Exposure to sunlight may exacerbate this condition. To help prevent the worsening of melasma: 

  • Restrict outdoor activities 
  • Avoid tanning beds and sunlamps 
  • Use sunscreen  
  • Wear protective clothing when going outdoors 

Estrace is contraindicated in pregnancy. In the event of a suspected or confirmed pregnancy, immediate medical consultation with a doctor is advised. 

Estrace negatively impacts the amount and quality of breast milk and has been detected in the milk of lactating mothers who use it. Inform your healthcare provider if you are currently breastfeeding. 

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Estrace (Estradiol). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Estrace (Estradiol).