Flagystatin Suppository (Metronidazole/Nystatin) Medication


Flagystatin Suppository (Metronidazole/Nystatin)

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Drug Description


Flagystatin Suppository is prescribed for treating and mitigating vaginal infections caused by microorganisms (Trichomonas vaginalis and Candida albicans). 

Formulated with antibacterial and antifungal agents (metronidazole/nystatin), Flagystatin Suppository works by killing the microorganisms responsible for vaginal infections. 

Uses and Dosage 

Before using Flagystatin Suppository and with every prescription refill, thoroughly review the provided medication guide and patient information leaflet. Should you have any inquiries or require further information, seek guidance from your doctor or pharmacist. 

Flagystatin Suppository is intended to be inserted deeply into the vagina, where it dissolves naturally through body heat. 

Typically, one suppository is administered before bedtime daily for 10 consecutive days. 

If, after the initial 10-day treatment period, a cure has not been attained, a secondary 10-day course of treatment may be recommended by your doctor. 

Utilize the supplied applicator for the correct administration of Flagystatin Suppository.  

To properly use the applicator: 

  1. Pull the applicator plunger back approximately 2.5 centimeters (1 inch). 
  2. Unwrap the suppository from its plastic packaging by separating the tabs. 
  3. Place the suppository into the cup at the end of the hollow tube (applicator). 
  4. Lie on your back with your knees drawn up. 
  5. Gently insert the applicator into your vagina as far as it comfortably goes. 
    • Do not attempt to force it further. 
  6. Ensure the applicator is correctly positioned in your vagina before pushing the plunger. 
  7. Push the plunger to release the suppository into your vagina. 
  8. Carefully remove the applicator and wash it with mild soap and warm water. 
    • Thoroughly rinse and dry it for future use. 

For the best results, follow the precise instructions for Flagystatin Suppository administration. Ensure consistent usage at the same times every day throughout the prescribed treatment period. 

Do not stop using this medication without consulting your doctor. 

In case of a missed Flagystatin dose, consult your doctor for guidance. Do not insert two suppositories to compensate for a missed dose. 

Side Effects 

Common Side Effects

Should any of these effects last or worsen, inform your doctor. 

  • Mild vaginal burning or gritty sensation 
  • Darkened urine 
  • Constipation 
  • Dry mouth 
  • Bitter or metallic taste in the mouth 
  • Stomach upset (indigestion) 
  • Reduced appetite 
  • Nausea 
  • Vomiting 
  • Depression 
  • Headache 
  • Difficulty sleeping 
  • Hearing impairment 
  • Auditory disturbances like buzzing, ringing, or whistling in the ear 

Serious Side Effects 

  • Severe diarrhea 
  • Vaginal irritation 
  • Liver problems with symptoms of: 
    • Jaundice (yellowing of the skin and eyes) 
    • Pain or swelling in the upper right stomach area 
    • Nausea or vomiting 
    • Unusual dark urine 
    • Unusual fatigue 
  • Nervous system problems, with symptoms of: 
    • Difficulty in movement 
    • Seizures 
    • Skin tingling 
  • Mental health concerns: 
    • Irrational thoughts 
    • Hallucinations 
    • Confusion 
    • Depression 
  • Self-harm or suicidal thoughts 
  • Vertigo (spinning sensation) 
  • Reduction in specific blood cell counts, with symptoms of: 
    • Fever 
    • Signs of infection, such as chills, body aches, sore throat 
    • Extreme fatigue 
  • Meningitis with symptoms like: 
    • Sudden, high fever 
    • Severe headache 
    • Stiff neck 
    • Confusion 
    • Nausea 
    • Vomiting 

Discontinue the use of Flagystatin Suppository and promptly seek medical assistance if any severe side effects occur. 

Severe Cutaneous Adverse Reactions (SCAR) 

Severe skin reactions with potential organ involvement can occur while using Flagystatin Suppository. Cease the use of this medication and seek immediate medical assistance if you encounter any of the following: 

  • Skin peeling, scaling, or blistering (with or without pus) affecting the eyes, mouth, nose, or genitals, accompanied by itching, a severe rash, subcutaneous bumps, skin discomfort, and alterations in skin color (redness, yellowing, purplish) 
  • Swelling and redness of the eyes or face 
  • Flu-like symptoms, including fever, chills, body aches, swollen glands, and cough 
  • Experiencing shortness of breath, chest pain, or discomfort 

Allergic Reactions 

Cease using Flagystatin Suppository and seek prompt medical assistance if you experience any of the following indications of an allergic reaction: 

  • Difficulty swallowing or breathing 
  • Wheezing 
  • Drop in blood pressure 
  • Nausea and vomiting 
  • Hives or rash 
  • Swelling of the face, lips, tongue, or throat 

This list does not cover all side effects of Flagystatin Suppository. Report to your doctor if you observe any other effects. 


Before starting treatment with Flagystatin Suppository, inform your doctor if you have any known hypersensitivities, particularly to metronidazole, nystatin, or any of the inactive ingredients in this suppository. 

Disclose to your doctor your medical background before using Flagystatin Suppository to assess its suitability to your condition, particularly if you have a history of: 

  • Liver disease 
  • Nervous system problem 
  • Blood problem (e.g., leukemia or hemophilia) 
  • Thyroid problem 
  • Hypoadrenalism (underactive adrenal glands) 

Inform your doctor about all the medications you are currently taking, including prescription and nonprescription medicines, vitamins, and herbal supplements, to prevent interactions with the Flagystatin Suppository. 

 Flagystatin Suppository may interact with the following substances: 

  • Alcohol  
  • Medications containing alcohol 
  • Blood thinners like warfarin 
  • Busulfan (e.g., Myleran) 
  • Cyclosporine (e.g., Neoral) 
  • Disulfiram 
  • 5-fluorouracil (e.g., fluorouracil or “5-FU” injection) 
  • Lithium (e.g., Carbolith, Lithane, Lithmax) 
  • Phenobarbital 
  • Phenytoin (e.g., Dilantin) 
  • Medications that may affect heart rhythm (QT prolongation), such as specific antiarrhythmics, certain antibiotics, and psychotropic medications 

Refrain from driving or operating machinery while undergoing Flagystatin treatment, as it can lead to confusion, dizziness, vertigo, hallucinations, seizures, or eye-related issues. 

Flagystatin Suppository can affect specific blood test results, potentially causing false negatives or unusually low readings. Prior to any blood tests, inform all laboratory staff about your use of this medication. 

Avoid using vaginal douches, menstrual tampons, and acidic pH soaps (for personal hygiene) while under the treatment of Flagystatin, as they can encourage fungal growth. 

Females whose sexual partners have been confirmed to have trichomoniasis infections should likewise undergo oral treatment simultaneously to prevent reinfection. 

The use of condoms or diaphragms during Flagystatin treatment is discouraged because some of the fatty components in the suppository may compromise their effectiveness. 

Pregnant patients in their first trimester should refrain from using Flagystatin Suppository. However, if the benefits to the mother outweigh the potential risks to the fetus, your doctor may prescribe this medication.  

The applicator should not be used beyond the 7th month of pregnancy. Ask your doctor for more information. 

There is no data regarding the transfer of nystatin in breast milk, but metronidazole is excreted in human milk, making this suppository unsuitable for breastfeeding women. 

Additional information

Generic name:



Vaginal suppository



Quantities Available:


Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Flagystatin Suppository (Metronidazole/Nystatin). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Flagystatin Suppository (Metronidazole/Nystatin).