Macrodantin (Nitrofurantoin Macrocrystal) Medication

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Macrodantin is a prescription medicine indicated for treating or preventing urinary tract infections caused by certain susceptible strains of bacteria. 

Categorized as an antibacterial agent, Macrodantin works by eradicating infection-causing bacteria. 

Macrodantin is not effective against viral infections like the common cold and flu. Inappropriate use of this and other antibiotics raises the likelihood of contracting antibiotic-resistant infections in the future. 

Uses and Dosage 

Before taking Macrodantin and every time you get a refill, carefully peruse its medication guide and patient information leaflet. Consult with your physician or pharmacist if you have any questions or concerns. 

The dose and duration of Macrodantin intake depend on the individual’s medical condition and response to the treatment. In children, the dosage is also determined by their body weight. 

Typically, Macrodantin is taken four times daily with food or milk as instructed by a physician for treating an infection or once a day at bedtime to prevent infections. 

To achieve optimal results, take Macrodantin at evenly spaced intervals around the same time each day, as prescribed. Refrain from altering the medication’s dosage, frequency, or duration without a doctor’s approval. 

Complete the entire prescription of Macrodantin, even if symptoms subside. Discontinuing this medication prematurely or missing doses may result in a more challenging treatment process and antibiotic resistance in the bacteria. 

Side Effects 

Listed below are potential adverse reactions associated with the use of Macrodantin. Tell your doctor or pharmacist promptly if any of them persists or worsens. 

Common Side Effects 

  • Headache 
  • Dizziness 
  • Drowsiness 
  • Weakness 
  • Gas 
  • Indigestion 
  • Loss of appetite 
  • Nausea 
  • Vomiting 
  • Muscle or joint pain 
  • Rash 
  • Itching 
  • Temporary hair loss 

Serious Side Effects 

  • Severe stomach pain or watery or bloody diarrhea (even if occurring months after the last dose) 
  • Vision problems 
  • Fever, chills, cough, chest pain, and difficulty breathing 
  • Numbness, tingling, or burning pain in hands or feet 
  • Severe pain behind the eyes 
  • Pale skin and weakness 
  • Joint pain or swelling with fever, swollen glands, and muscle aches 
  • Pain, redness, or swelling in the lower jaw 
  • Increased pressure inside the skull, resulting in: 
    • Severe headaches 
    • Ringing in the ears 
    • Dizziness 
    • Nausea 
    • Vision problems 
  • Signs of liver or pancreas problems: 
    • Upper stomach pain (spreading to the back) 
    • Nausea or vomiting 
    • Dark urine 
    • Yellowing of the skin or eyes 

Call your doctor immediately if you experience any of the severe side effects listed above. 

Allergic Reactions 

Although uncommon, a severe allergic reaction to Macrodantin may occur. Immediate medical assistance should be sought if the symptoms below are observed: 

  • Rash 
  • Severe dizziness 
  • Trouble breathing 
  • Facial, tongue, or throat itching/swelling 

A severe skin reaction may also occur while taking Macrodantin. Get emergency medical help if you experience the following symptoms: 

  • Fever 
  • Sore throat 
  • Burning eyes 
  • Skin pain 
  • Red or purple skin rash with blistering and peeling 

The enumerated side effects of Macrodantin are not exhaustive. If any unlisted symptoms occur, promptly inform your doctor. 


Before starting treatment with Macrodantin, inform your healthcare provider or pharmacist about any allergic reactions you may have had, especially to nitrofurantoin or any other medicine. 

Inactive ingredients in this medication may cause allergic reactions or other problems. Request a list of ingredients from your pharmacist for further details. 

To ensure that Macrodantin is safe for you, disclose to your doctor your medical history, particularly of:  

  • Kidney disease 
  • Liver disease (including liver problems from prior nitrofurantoin use) 
  • G-6-PD deficiency 
  • Blood disorders (e.g., anemia) 
  • Lung diseases 
  • Peripheral neuropathy  
  • Optic neuritis  
  • Diabetes 
  • Untreated mineral imbalance 
  • Vitamin B deficiency 

Many drugs may interact with Macrodantin, including sulfinpyrazone. To mitigate the risk of drug interactions, inform your doctor and pharmacist about all your prescription and over-the-counter medicines, vitamins, and herbal medications. 

Do not take antacids containing magnesium trisilicate while being treated with Macrodantin since magnesium trisilicate can bind with nitrofurantoin and hinder its complete absorption. 

Macrodantin may interfere with the effectiveness of live bacterial vaccines, such as the typhoid vaccine. Before receiving any immunizations or vaccinations, inform your healthcare provider that you are taking this medication. 

Macrodantin may impact the results of particular urine glucose tests (cupric sulfate-type). Inform your healthcare providers and the laboratory personnel that you are taking this medication. 

Extended or recurrent use of Macrodantin may lead to the development of oral thrush or a new fungal infection in the vagina. If you experience new symptoms, such as white patches in the mouth, changes in vaginal discharge, or other symptoms, consult your doctor immediately. 

During pregnancy, Macrodantin should only be used if it is deemed necessary. This medication should be avoided during weeks 38-42 of pregnancy, as it may cause harm to the newborn, such as hemolytic anemia. Discuss the potential risks and benefits with your doctor before use. 

Nitrofurantoin is excreted in breast milk and may adversely affect nursing infants under one month old or those with G-6-PD deficiency. If you are breastfeeding, consult your doctor before continuing. 

Additional information

Generic name:

Nitrofurantoin Macrocrystal




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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Macrodantin (Nitrofurantoin Macrocrystal). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Macrodantin (Nitrofurantoin Macrocrystal).