Indications 

Medrol is a prescription medication indicated for treating inflammatory conditions that affect various parts of the body, including the skin, eyes, lungs, stomach, nervous system, blood cells, and other related conditions such as arthritis, lupus, psoriasis, ulcerative colitis, and allergic and endocrine disorders. 

As a glucocorticoid, Medrol reduces the immune system’s reaction to different illnesses, thereby minimizing symptoms like pain, swelling, and allergic reactions. 

Uses and Dosage 

Before taking Medrol and every time you get a refill, carefully read its medication guide and patient information leaflet. If you have any questions or concerns, consult with your doctor or pharmacist. 

The dosage and duration of Medrol intake vary for each individual depending on their medical condition and response to the treatment.  

Typically, Medrol is taken with food or milk, as directed by the doctor. Various dosing schedules are available, so adhere strictly to the regimen prescribed by your doctor. 

Avoid increasing your dose or using Medrol more frequently or for a more extended period than prescribed. This will not hasten the improvement of your condition and will increase the likelihood of side effects. 

Abrupt cessation of Medrol is not recommended. Adhere to your doctor’s guidance on gradually reducing your dosage. 

Side Effects 

Listed below are the possible side effects of Medrol. Notify your doctor or pharmacist immediately if any of them persist or worsen. 

Common Side Effects 

• Fluid retention resulting in swelling of the hands or ankles 
• Dizziness or vertigo 
• Changes in menstrual cycles 
• Headache 
• Mild muscle weakness or pain 
• Stomach discomfort or bloating 

Serious Side Effects 

• Shortness of breath (even with mild exertion) 
• Swelling or rapid weight gain 
• Bruising, thinning skin, or non-healing wounds 
• Blurred vision, tunnel vision, eye pain, or seeing halos around lights 
• Severe depression, changes in personality, or unusual thoughts or behavior 
• New or unusual pain in an arm or leg, or back 
• Bloody or tarry stools, coughing up blood, or vomit resembling coffee grounds 
• Seizures (convulsions) 
• Indications of low potassium levels: 
  • Leg cramps 
  • Constipation 
  • Irregular heartbeats 
  • Palpitations 
  • Increased thirst or urination 
  • Numbness or tingling 

Notify your doctor immediately if you experience any of the severe side effects listed above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Medrol can occur. Seek immediate medical attention if you experience the following symptoms: 

• Rash 
• Severe dizziness 
• Trouble breathing 
• Facial, tongue, or throat itching/swelling 

The enumerated side effects of Medrol are not exhaustive. If you experience any unlisted symptoms that become bothersome, inform your doctor immediately. 

Cautions 

Before starting treatment with Medrol, inform your healthcare provider or pharmacist about any history of allergic reactions, particularly to methylprednisolone, aspirin, tartrazine (a yellow dye found in some processed foods and medications), or any other drugs. 

The inactive ingredients in this medication may cause allergic reactions or other issues. Request a list of ingredients from your pharmacist for additional information. 

To ensure that Medrol is safe for you, disclose your medical history to your doctor, particularly of:  

• Bleeding problems 
• Blood clots 
• Brittle bones (osteoporosis) 
• Diabetes 
• Eye diseases: cataracts, glaucoma, or herpes infection of the eye 
• Heart problems: recent heart attack or congestive heart failure 
• High blood pressure 
• Current or past infections, such as those caused by tuberculosis, threadworm, herpes, or fungus 
• Kidney disease 
• liver disease 
• Mental or mood conditions:  psychosis, depression, or anxiety 
• Stomach or intestinal problems: diverticulitis, ulcer, or ulcerative colitis 
• Seizures 

Before taking Medrol, inform your doctor and pharmacist about all your medications, including prescription and over-the-counter medicines, vitamins, and herbal products, to prevent any potential drug interactions. 

Some products that may interact with Medrol include: 

• Aldesleukin 
• Mifepristone 
• Other drugs that can cause bleeding or bruising: 
  • Atiplatelet drugs such as clopidogrel 
  • Blood thinners such as warfarin/dabigatran 
• Nonsteroidal anti-inflammatory drugs (NSAIDs): 
  • Ibuprofen 
  • Celecoxib 
  • Aspirin 
  • Salicylates 

If your doctor has prescribed low-dose aspirin for heart attack or stroke prevention (usually 81-162 milligrams a day), do not stop taking it unless instructed otherwise. 

Several medications can alter the metabolism of Medrol, impacting its effectiveness. Some of them are: 

• Azole antifungals, such as ketoconazole 
• Immunosuppressant drug cyclosporine 
• Estrogens 
• HIV protease inhibitors, including darunavir 
• Macrolide antibiotics like erythromycin 
• Ritonavir 
• St. John’s wort 
• Some anti-seizure medications like phenytoin and phenobarbital 

Avoid individuals who are sick or have infections. If exposed to chickenpox or measles, contact your doctor for preventative treatment. These illnesses can be severe or fatal for those taking steroid medication like Medrol. 

Inform your healthcare provider about your use of Medrol before receiving any immunizations, vaccinations, or skin tests. Avoid contact with individuals who have received live vaccines, such as nasal flu vaccine, within the past few weeks. 

Medrol can potentially disrupt certain laboratory tests, such as skin tests, leading to inaccurate results. Inform laboratory personnel and all physicians involved in your care that you are taking this medication. 

Prolonged use of corticosteroids like Medrol may decrease the body’s ability to respond to physical stress. Before undergoing surgery or emergency treatment, or in case of a severe illness/injury, notify your doctor or dentist of your current or past use of this medication within the last 12 months. If you anticipate long-term use, carry a warning card or medical ID bracelet to indicate your medication use. 

Medrol may impede a child’s growth if used for an extended period. Ensure that the child undergoes regular check-ups with their doctor to monitor height and growth. 

The potential harm of Medrol to a developing fetus is unknown. Inform your physician of your pregnancy status or plans. 

The transfer of methylprednisolone into breast milk and its impact on a nursing infant is uncertain. Consult your physician before breastfeeding.