Indications 

Megace is a prescription medicine indicated for treating advanced breast or uterine cancer in patients whose cancer has metastasized, recurred, or is unsuitable for surgical intervention. 

Megace is a synthetic version of progesterone and works by impeding the stimulation of cell growth dependent on estrogen and obstructs estrogen production, hindering tumor growth. The consequent estrogen level reduction curbs cancer cell proliferation and multiplication. 

Uses and Dosage 

Before taking Megace and every time you get a refill, carefully read its medication guide and patient information leaflet. If you have any questions or concerns, consult with your physician or pharmacist. 

The dosage and frequency of Megace intake vary for each individual depending on their medical condition and response to the treatment.  

Typically, Megace is taken several times a day. Follow your doctor’s instructions precisely, and do not exceed or reduce the dosage or take it more frequently than prescribed. 

To achieve optimal results, take Megace at the same time daily, and do not discontinue its use without consulting your physician. 

Side Effects 

Listed below are the possible side effects of Megace. Tell your doctor or pharmacist immediately if any of them persist or worsen. 

Common Side Effects 

• Fluid retention resulting in swelling of the hands or ankles 
• Nausea 
• Gas 
• Diarrhea 
• Elevated blood pressure 
• Impotence or sexual problems 
• Rash 
• Weakness 

Serious Side Effects 

• Chest pain, sudden cough, wheezing, rapid breathing, or coughing up blood 
• Swelling, warmth, or redness in an arm or leg 
• Increased thirst, increased urination, dry mouth, or fruity breath odor 
• Weight gain (particularly in the waist and upper back) 
• Muscle weakness, tiredness, or feeling light-headed 
• Skin discoloration, thinning skin, or increased body hair 
• Mood changes, menstrual changes, or sexual changes 

Immediately notify your doctor if you experience any of the above-mentioned side effects while undergoing or after Megace treatment 

Allergic Reactions 

Although rare, a severe allergic reaction to Megace can occur. Get immediate medical attention if you experience the following symptoms: 

• Rash 
• Severe dizziness 
• Trouble breathing 
• Facial, tongue, or throat itching/swelling 

This list of Megace side effects is not comprehensive. Inform your doctor immediately if you encounter any unlisted symptoms that cause discomfort. 

Cautions 

Before starting treatment with Megace, inform your healthcare provider or pharmacist about any history of allergic reactions, particularly to megestrol or any other medications. 

The inactive ingredients in this medication may trigger allergic reactions or other issues. Obtain a list of ingredients from your pharmacist for additional information. 

To ensure that Megace is safe for you, disclose your medical history to your doctor, particularly of:  

• Adrenal gland issues: Cushing’s syndrome 
• Blood clots 
• Diabetes 
• Heart disease: congestive heart failure 
• High blood pressure 
• Kidney disease 
• Stomach or abdominal problems 
• Unusual vaginal bleeding 

Dofetilide is among the products that may interact with Megace. To avoid potential drug interactions, notify your doctor and pharmacist about all your medications, such as prescription and over-the-counter medicines, vitamins, and herbal products. 

Megace should not be used during pregnancy. Effective contraception options should be discussed with a doctor when taking this medication. If pregnancy occurs, consult a physician immediately to evaluate the benefits and risks of continuing Megace. 

Pregnant women or those who may become pregnant should not handle this medication or inhale the tablet dust, for it can harm the unborn baby if absorbed through the skin or lungs. 

Seek your physician’s advice before breastfeeding, as megestrol can be transferred through breast milk.