Indications 

Menopur is prescribed to ovulatory women undergoing Assisted Reproductive Technology (ART) cycles to aid in developing multiple follicles and increase the chances of pregnancy. 

As a gonadotropin, Menopur facilitates the production of eggs by supplying follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to the ovaries.  

This medication is often used in conjunction with human chorionic gonadotropin (hCG) to encourage the growth and release of a mature egg, thereby improving the likelihood of pregnancy through ovulation. 

Uses and Dosage 

Before starting treatment with Menopur and with each prescription refill, carefully review its medication guide and patient information leaflet.  

Ensure to receive proper training from a healthcare professional on preparing and injecting this medication. Should you have any inquiries, seek guidance from your doctor or pharmacist. 

The maximum daily dosage of Menopur is 450 international units, and a treatment cycle not exceeding 20 days. However, dosage and length of treatment may vary per individual based on medical condition, response to the treatment, and concurrent medications. 

Menopur is administered subcutaneously once daily as prescribed by your doctor.  

To properly use this medication: 

1. Wash your hands thoroughly with soap and water before administering this medication. 
2. Prepare the solution as instructed by your doctor and check for particles or discoloration. If either is present, do not use it; if none, use it right after mixing. 
3. Before injecting each dose, clean the injection site using rubbing alcohol. 
4. Inject Menopur as instructed by your doctor. 
5. Rotate the injection site daily to prevent discomfort and potential issues beneath the skin. 
6. Dispose of needles in a designated needle/sharp disposal box. Never reuse needles or other items. 

Use Menopur exactly as directed to achieve optimal results. To aid in adherence, administer it around the same time each day. 

Do not alter the prescribed dosage or extend the duration of use of Menopur without consulting your doctor. 

Side Effects 

Listed below are the potential adverse effects of Menopur. Inform your doctor if any of these symptoms last or worsen. 

Common Side Effects 

• Injection site irritation 
• Upset stomach 
• Headache 
• Abdominal pain 
• Stomach cramps 
• Feeling of fullness 

Serious Side Effects 

• Breast pain 
• Enlarged breasts 
• Fast heartbeat 
• Yellowing of the skin or eyes 
• Rapid breathing 
• Pale skin 
• Bluish discoloration of the lips, nail beds, fingers, or toes 
• Flu-like symptoms 
• Ovarian hyperstimulation syndrome (OHSS) symptoms: 
  • Severe stomach pain or bloating 
  • Upset stomach, vomiting, or diarrhea 
  • Significant weight gain 
  • Shortness of breath 
  • Changes in urination frequency 
• Blood clotting: 
  • Chest, arm, back, neck, or jaw pain or pressure 
  • Coughing up blood 
  • Numbness or weakness on one side of the body, difficulty speaking or thinking, balance changes, or vision changes 
  • Shortness of breath 
  • Swelling, warmth, or pain in the leg or arm 

Call your doctor immediately and ask for medical help if you experience any of the severe side effects mentioned above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Menopor may occur. Seek immediate medical assistance if you observe any of the following symptoms: 

• Hives 
• Itching 
• Red, swollen, blistered, or peeling skin (with or without fever) 
• Wheezing 
• Tightness in the chest or throat 
• Difficulty breathing, swallowing, or talking 
• Unusual hoarseness 
• Swelling of the mouth, face, lips, tongue, or throat 

This list does not contain all the potential side effects of Menopur. If you experience any unlisted effects, notify your doctor without delay. 

Cautions 

Menopur is contraindicated for women with primary ovarian failure, where the ovaries are unable to produce eggs effectively. 

Before starting treatment with Menopur, inform your doctor and pharmacist if you have any known hypersensitivities, especially to: 

• Menotropins 
• Other medications that contain follicle-stimulating hormone or luteinizing hormone 
• Any ingredients present in Menopur solution 

To ensure Menopur is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Other fertility problems (e.g., primary ovarian failure) 
• Abnormal uterine/vaginal bleeding 
• Thyroid problems 
• Adrenal gland problems 
• Reproductive organ cancer (breast, uterus, ovary) 
• Brain tumor (e.g., pituitary tumor) 
• Ovarian cysts/enlarged ovaries (not due to polycystic ovary syndrome) 
• Twisting of the ovary (ovarian torsion) 
• Personal/family history of blood clots 
• Blood clotting disorders (e.g., thrombophilia) 
• Obesity 
• Stroke 
• Certain heart diseases (e.g., heart attack) 
• Lung problems (e.g., asthma) 

Some medications may interact with Menopur, including gonadorelin. To lower the risk of drug interactions, tell your doctor and pharmacist about all medications you use, including prescription/nonprescription drugs, vitamins, and herbal products. 

The use of Menopur may cause dizziness, which can be further intensified by consuming alcohol or marijuana (cannabis). Restrict alcohol intake, consult your doctor if you use marijuana (cannabis), and refrain from activities such as driving, operating machinery, or anything that requires alertness until you can safely do so. 

Menopur increases the likelihood of multiple pregnancies. Some women may also have an increased risk of ectopic pregnancy. Consult your doctor for further discussion. 

Discontinue use of Menopur upon pregnancy confirmation. This medication is contraindicated during pregnancy. Promptly inform your doctor if you suspect pregnancy. 

The transfer of menotropins into breast milk is uncertain. Prior to breastfeeding, consult your doctor for guidance.