Indications 

Monopril is a prescribed medication used alone or in combination with other medicines to treat hypertension and heart failure. 

Categorized as an angiotensin-converting enzyme (ACE) inhibitor, Monopril functions by reducing the levels of certain chemicals that constrict blood vessels, resulting in improved blood flow and enhanced cardiac efficiency. 

Uses and Dosage 

Before starting treatment with Monopril and with each prescription refill, carefully review its medication guide and patient information leaflet. Consult your doctor or pharmacist if you have questions or uncertainties. 

The dosage of Monopril is determined based on the patient’s medical condition and response to the treatment. 

Typically, Monopril is taken once or twice daily as directed by the doctor, without regard to food intake. 

For optimal results, take this medication regularly around the same time(s) each day. Adhere to how it is prescribed, and do not alter dosage and frequency of intake without your doctor’s approval. 

Continue taking Monopril even if you are symptom-free. Consult your doctor before discontinuing its use. 

Side Effects 

Listed below are the potential adverse effects of Monopril. If any of them persist or worsen, tell your doctor promptly. 

Common Side Effects 

• Cough, runny or stuffy nose 
• Muscle or joint pain 
• Dizziness, headache, tired feeling 
• Nausea, vomiting, diarrhea 
• Mild skin itching or rash 

Serious Side Effects 

• Light-headed feeling, potentially leading to fainting 
• Sudden weakness or feeling unwell, accompanied by fever, chills, sore throat, painful mouth sores, cough, or difficulty breathing 
• Reduced or no urination 
• High potassium levels: 
  • Nausea 
  • Slow or irregular heart rate 
  • Weakness 
  • Loss of movement 

Call your doctor right away if any of the severe side effects listed above are experienced. 

Allergic Reactions 

Although rare, a severe allergic reaction to Monopril may occur. Seek immediate medical assistance if you experience any of the following symptoms: 

• Hives 
• Severe abdominal discomfort 
• Breathing difficulties 
• Face, lips, tongue, or throat swelling 

This list does not contain all the potential side effects of Monopril. If you observe any unlisted effects, tell your doctor promptly. 

Cautions 

Before starting treatment with Monopril, inform your doctor and pharmacist if you have any known hypersensitivities, especially to: 

• Fosinopril 
• Other ACE inhibitors (e.g., benazepril) 
• Other medications 
• Any ingredients present in Monopril tablets 

To ensure Monopril is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Allergic reactions involving swelling of the face, lips, tongue, or throat (angioedema) 
• Blood filtering procedures like LDL apheresis or dialysis 
• Elevated levels of potassium in the blood 

Inform your doctor and pharmacist about all prescription, nonprescription medications, vitamins, nutritional supplements, and herbal products you currently use or intend to use to avoid drug interaction with Monopril. 

Some of the products that may interact with this Monopril include: 

• Aliskiren 
• Certain immune-weakening or infection-risk-increasing drugs (such as everolimus, sirolimus) 
• Lithium 
• Medications that may elevate blood potassium levels (such as ARBs like losartan/valsartan and drospirenone-containing birth control pills) 
• Sacubitril 

The absorption of Monopril may be reduced by antacids with aluminum or magnesium. To mitigate this interaction, take such antacids 2 hours before or after consuming this medication. 

Exercise caution when taking cough-and-cold products, diet aids, and non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen, as certain ingredients in these products, could potentially increase your blood pressure or worsen your heart failure.  Seek guidance from your doctor on how to safely use these products. 

Low-dose aspirin (typically 81-162 milligrams per day) prescribed for heart attack or stroke prevention should be continued unless otherwise instructed by your doctor. 

Consult your doctor or pharmacist before using potassium supplements or salt substitutes containing potassium, as Monopril may elevate your potassium levels. 

Monopril can cause dehydration, which may result in severe hypotension, electrolyte imbalances, or renal dysfunction. Call your doctor promptly in case of persistent vomiting, diarrhea, or excessive sweating.   

Monopril may cause dizziness, and consumption of alcohol or use of marijuana (cannabis) can exacerbate this effect. Restrict alcohol intake and consult your doctor if you use marijuana (cannabis). Avoid driving, operating machinery, or engaging in activities that require alertness until you can safely do so. 

Monopril is contraindicated during pregnancy. If pregnancy occurs, discontinue this medication and promptly inform your doctor. Taking Monopril during the second or third trimester can potentially harm or lead to fetal death. 

Breastfeeding should be avoided while taking Monopril as its active ingredient fosinopril can be transmitted through breast milk and cause harm to the nursing infant.