Motilium (Domperidone) Medication


Motilium (Domperidone)

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Drug Description


Motilium is a prescribed medication utilized for various conditions, such as: 

  • Treating nausea and vomiting, including those caused by migraine headaches 
  • Preventing nausea and vomiting caused by specific medications used in Parkinson’s disease treatment, like levodopa and pergolide 
  • Alleviating discomfort caused by gastroparesis, a condition characterized by a slow-moving stomach, which may manifest as indigestion (dyspepsia), incomplete meal consumption, post-meal fullness or bloating, reduced appetite, feelings of sickness, potential vomiting, or unproductive belching 

Motilium is a dopamine antagonist drug that functions as an antiemetic and prokinetic agent. By blocking dopamine receptors in the gut, this medication enhances muscle contractions in the digestive tract, facilitating food movement.  

Moreover, this medication affects the chemoreceptor trigger zone in the brain, reducing feelings of nausea and vomiting. 

Uses and Dosage 

Before starting treatment with Motilium and with each prescription refill, carefully review its medication guide and patient information leaflet. Consult your doctor or pharmacist if you have queries or uncertainties. 

The appropriate dosage and duration of Motilium usage vary based on the individual’s medical condition and response to treatment. 

Typically, this medication is taken 3 to 4 times a day as prescribed by the doctor. Tablets must be swallowed whole with a glass of water and should not be crushed or chewed. 

To ensure optimal absorption, take Motilium 15 to 30 minutes before meals. Taking them after meals may cause a slight delay in absorption.  

Take this medication exactly as directed. Refrain from altering the prescribed dosage, frequency, or duration of intake without consulting your doctor. 

Side Effects 

Listed below are the potential adverse effects of Motilium. If any of them last or worsen, tell your doctor promptly. 

Common Side Effects 

  • Dry mouth 

Serious Side Effects 

  • Uncontrolled movements (particularly in children) such as: 
  • Irregular eye movements 
  • Abnormal tongue movements 
  • Twisted neck 
  • Trembling 
  • Muscle stiffness 
  • Very fast or unusual heartbeat 
  • Seizure  

Call your doctor right away if any of the severe side effects above are experienced. 

Allergic Reactions 

Although rare, a severe allergic reaction to Motilium may occur. Seek prompt medical assistance if you observe any of the following symptoms: 

  • Swelling of the hands, feet, ankles, face, lips, or throat, leading to difficulty swallowing or breathing 
  • An itchy, lumpy rash (hives) or nettle rash (urticaria) 

This list does not contain all the potential side effects of Motilium. If any unlisted effects are observed, notify your doctor promptly. 


Before starting treatment with Motilium, inform your doctor if you have any known hypersensitivities, especially to domperidone, other medications, or any ingredients present in Motilium tablets. 

To ensure Motilium is safe for you, disclose to your physician your medical background, especially of: 

  • Gastrointestinal bleeding 
  • Recent abdominal surgery 
  • Pituitary gland tumor 
  • Liver or kidney problems 
  • Heart problems or irregular heartbeat 
  • Weight below 77 pounds 
  • Bowel obstruction, Crohn’s disease, or diverticulitis 

Tell all healthcare providers of your current and new medication usage, as Motilium may interact with other drugs such as prescriptions, over-the-counter medicines, vitamins, and herbal products. 

Some of the medications that can interact with Motilium are: 

  • Antipsychotics or antidepressants 
  • Antibiotics or antifungal medicines 
  • HIV medicines 
  • Malaria medicines 
  • Medicines for high blood pressure or heart problems 
  • Medicines or treatments for cancer 

The use of Motilium can heighten the possibility of heart rhythm issues and cardiac arrest, particularly in individuals above 60 years old or consuming doses exceeding 30 mg daily. Discontinue the use of this medication and call your doctor if you encounter symptoms such as: 

  • Palpitations 
  • Difficulty breathing 
  • Loss of consciousness 

Motilium should only be used during pregnancy if the anticipated therapeutic benefit justifies the potential risks. Consult your doctor for guidance before taking this medication. 

Trace amounts of domperidone have been found in breast milk, posing a potential risk of heart-related side effects in breast-fed infants. The use of this medication during breastfeeding should be limited to cases where a doctor determines its necessity.  

Additional information

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Motilium (Domperidone). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Motilium (Domperidone).