Indications 

Motilium DT (generically known as Domperidone) is an oral medication primarily used for the treatment of symptoms such as indigestion, nausea, and vomiting. It can be prescribed to treat certain stomach and esophagus problems such as gastroesophageal reflux disease (GERD) and gastroparesis. It helps improve breast milk supply in lactating women by increasing the levels of prolactin, a hormone involved in breast milk production. 

Domperidone works by blocking certain receptors in the body, specifically dopamine and serotonin receptors. By blocking these receptors, Domperidone increases the movement of food through the stomach and prevents nausea and vomiting.  

Use and Dosage 

Domperidone comes in the form of DT tablets and is taken before meals, usually one tablet (5 mg) taken three times a day. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet before swallowing. The tablets should be swallowed whole with a glass of water. 

The usual starting dose of domperidone for adults is 10 mg taken three times a day. The maximum recommended daily dose is 30 mg. Domperidone is typically taken before meals, but if taken after meals, absorption of the drug may be somewhat delayed. 

If you miss a dose of Motilium DT, take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. 

Side Effects 

Common Side Effects  

• A blood test shows changes in the way your liver is working 
• Abnormal eye movements  
• Breast enlargement in men  
• Feeling agitated or irritable  
• Feeling more nervous than usual  
• In women, menstrual periods may be irregular or stop  
• Inability to urinate  

Serious Side Effects 

• Diarrhea 
• Feeling anxious 
• Feeling drowsy 
• Headaches 
• Irregular eye movements 
• Itchy skin 
• Lowering of sexual drive (libido) in men 
• Muscle stiffness 
• Painful or tender breasts 
• Seizure 
• Trembling 
• Unusual movements of the tongue, and abnormal posture such as a twisted neck 
• Unusual production of breast milk in men and women 
• Very fast or unusual heartbeat. 
• You get swelling of the hands, feet, ankles, face, lips, or throat which may cause difficulty in swallowing or breathing 
• You may also notice an itchy, lumpy rash (hives), or nettle rash (urticaria) 
• A general feeling of weakness 

Cautions 

• Cardiac issues: Domperidone may pose a risk to individuals with pre-existing heart conditions or those at risk of heart rhythm abnormalities. Discuss any cardiac concerns with your healthcare provider before starting or continuing treatment with Motilium DT. 
• Drug interactions: Domperidone can interact with other medications, including certain antibiotics, antifungal drugs, and medications that affect heart rhythm. Inform your healthcare provider about all the medications you are taking to avoid potential interactions. 
• Liver problems: Individuals with liver disease may require caution and close monitoring when using Motilium DT. Dose adjustments or alternative treatments may be necessary. Consult with your healthcare provider if you have any liver-related concerns. 
• Allergic reactions: Some individuals may be allergic to Domperidone. If you experience signs of an allergic reaction, such as rash, itching, swelling, dizziness, or difficulty breathing, seek immediate medical attention. 
• Pregnancy and breastfeeding: Motilium DT should be used with caution during pregnancy. Discuss the potential risks and benefits with your healthcare provider before using the medication. Domperidone passes into breast milk, so consult with your healthcare provider before using it while breastfeeding. 
• Gastrointestinal bleeding: Domperidone may mask the symptoms of gastrointestinal bleeding. If you experience symptoms such as stomach pain, vomiting blood, or dark stools, seek medical attention immediately. 
• Renal impairment: Individuals with severe kidney impairment may require caution and dose adjustments when using Motilium DT. Consult with your healthcare provider for personalized advice.