Indications 

Nidagel is a medication that contains the antibiotic Metronidazole and is used to treat bacterial infections of the vagina, specifically bacterial vaginosis.  

Metronidazole belongs to the class of medications called antibiotics. It works by killing the bacteria that cause the infection. It does this by interfering with their DNA and preventing them from reproducing. 

Nidagel is only effective against bacterial infections and will not work for vaginal yeast infections or other types of infections. 

Use and Dosage 

Nidagel is applied inside the vagina using a special applicator. It is a topical gel that is applied inside the vagina for a specific number of days, depending on the prescribed treatment plan. Use Nidagel for the full course of treatment, even if your symptoms improve before the medication is finished.  

To use Nidagel, follow these steps: 

1. Wash your hands thoroughly with soap and water. 
2. Remove the applicator from its packaging. 
3. Unscrew the cap from the tube of Nidagel and attach the applicator to the tube. 
4. Squeeze the tube to fill the applicator with the prescribed amount of Nidagel. 
5. Carefully insert the applicator into the vagina and push the plunger to release the medication. 
6. Remove the applicator and dispose of it properly. 

If you miss a dose of Nidagel, use it as soon as you remember. If the gel is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for a missed dose. 

Side Effects 

Common Side Effects  

• Buzzing, ringing, or whistling sound heard in the ears 
• Change in taste sensation 
• Coated or furry tongue 
• Darker urine 
• Diarrhea 
• Dizziness or lightheadedness 
• Headache 
• Loss of appetite 
• Nausea 
• Sleepiness 
• Stomach pain or cramps 
• Unpleasant or sharp metallic taste 
• Vomiting 

Serious Side Effects 

• A rash combined with fever or discomfort 
• A rash covering a large area of the body 
• A rash that spreads quickly 
• Any vaginal irritation, discharge, or dryness not present before use of the gel 
• Confusion 
• Convulsions (seizures) 
• Dark urine 
• Diarrhea, loss of appetite 
• Changes in sleep 
• Changes in weight 
• Decreased interest in activities 
• Difficulty breathing, itchy skin rash 
• Difficulty coordinating body movement 
• Extreme sensitivity to bright light 
• Burning on urination or need to urinate more often 
• Burning or irritation of the penis of the sexual partner 
• Feeling of vaginal pressure 
• Itching, pain, stinging, or redness of the genital area 

Cautions 

• Disulfiram-like reaction: Nidagel can cause a disulfiram-like reaction when taken with alcohol or certain medications containing alcohol. This can cause symptoms like nausea, vomiting, and flushing. Avoid alcohol while taking Nidagel. 
• Liver problems: Rarely, Nidagel can cause liver problems. Symptoms of liver problems may include yellowing of the skin or eyes, dark urine, and abdominal pain. If you experience any of these symptoms, contact your doctor immediately. 
• Neurological effects: Rarely, Nidagel can cause neurological effects, such as seizures or numbness and tingling in the hands and feet. If you experience any of these symptoms, contact your doctor immediately. 
• Allergic reactions: Some people may be allergic to Nidagel. Signs of an allergic reaction may include rash, itching, swelling of the face, tongue, or throat, and difficulty breathing. If you experience any of these symptoms, seek medical attention immediately. 
• Blood disorders: Rarely, Nidagel can cause blood disorders, such as leukopenia (low white blood cell count) or thrombocytopenia (low platelet count). Symptoms may include fever, sore throat, bruising, or bleeding. If you experience any of these symptoms, contact your doctor immediately. 
• Peripheral neuropathy: Rarely, Nidagel can cause peripheral neuropathy, which is damage to the nerves that control sensation and movement in the arms and legs. Symptoms may include numbness, tingling, or burning in the hands or feet. If you experience any of these symptoms, contact your doctor immediately. 
• Pregnancy and breastfeeding: Nidagel is considered safe to use during pregnancy and while breastfeeding. However, you should discuss the risks and benefits of using Nidagel with your doctor if you are pregnant or breastfeeding. 
• Interactions with other medications: Nidagel can interact with other medications, including blood thinners, seizure medications, and certain antibiotics. Tell your doctor about all medications you are taking before starting Nidagel. 
• Fungal infections: Nidagel is only effective against bacterial infections and will not work for vaginal yeast infections or other types of infections. If you develop a fungal infection while using Nidagel, contact your doctor.