Nocdurna (Desmopressin) Medication


Nocdurna (Desmopressin)

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Drug Description


Nocdurna is a prescribed medication for nocturnal polyuria, a condition characterized by excessive nighttime urine production, causing patients to wake up two or more times during the night to urinate. 

Classified as a vasopressin analog, Nocdurna mimics the action of vasopressin, a natural hormone in the body, to reduce the amount of urine produced by the kidneys during the night. 

Uses and Dosage 

Before taking Nocdurna and with each prescription refill, carefully review its medication guide and patient information leaflet. Inquire with your doctor or pharmacist regarding any questions or uncertainties. 

Nocdurna is available in the form of an orally disintegrating tablet. It should be placed under the tongue and allowed to dissolve completely without chewing or swallowing it whole. Ensure your hands are dry before handling the tablet. 

Typically, Nocdurna is taken once a day, an hour before bedtime. Restrict fluid intake, particularly one hour before and up to 8 hours after taking this medication. 

Furthermore, refrain from consuming beverages containing caffeine or alcohol before bedtime, and make sure to empty your bladder before going to sleep. 

For optimal results, take Nocdurna exactly as directed at a consistent time each day. Do not alter the prescribed dosage, frequency, and duration of intake without consulting your doctor. 

Side Effects 

Listed below are the potential adverse effects of Nocdurna. If any of them persist or worsen, notify your doctor promptly. 

Common Side Effects 

  • Flushing 
  • Dry mouth 
  • Dizziness 

Serious Side Effects 

  • Symptoms of low sodium levels: 
    • Headache 
    • Difficulty focusing 
    • Memory problems 
    • Confusion 
    • Weakness 
    • Seizures 
    • Balance changes 
  • Symptoms of high blood pressure: 
    • Severe headache 
    • Dizziness 
    • Fainting 
    • Changes in eyesight 
  • Upset stomach or vomiting 
  • Hallucinations  
  • Fatigue or weakness 
  • Restlessness 
  • Muscle weakness or spasms 
  • Loss of appetite 
  • Shortness of breath, significant weight gain, or swelling in the arms or legs 
  • Swelling, warmth, numbness, color changes, or pain in a leg or arm 
  • Chest pain, pressure, or rapid heartbeat 
  • Coughing up blood 
  • Weakness on one side of the body, difficulty speaking or thinking, balance changes, facial drooping, or blurred vision 
  • Irregular heartbeat sensation 

Call your doctor right away and ask for medical assistance if you experience any of the severe side effects listed above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Nocdurna may occur. Seek prompt medical assistance if you observe any of these symptoms: 

  • Rash 
  • Hives 
  • Itching 
  • Redness, swelling, blistering, or peeling skin (with or without fever) 
  • Wheezing 
  • Tightness in the chest or throat 
  • Difficulty breathing, swallowing, or speaking 
  • Unusual hoarseness 
  • Swelling (mouth, face, lips, tongue, or throat) 

Not all side effects of Nocdurna are included in this list. In case any unlisted effects occur, tell your doctor immediately.   


Before starting treatment with Nocdurna, inform your doctor and pharmacist of any known allergies, particularly to desmopressin, other drugs, or any components of this orally disintegrating tablet. 

To ensure Nocdurna is safe for you, disclose to your physician your medical background, especially if you have a history of: 

  • Kidney disease 
  • Heart problems (e.g., blocked blood vessels, heart failure) 
  • High blood pressure 
  • Low sodium level in the blood (hyponatremia) 
  • Conditions that may increase the risk of fluid/mineral imbalance (e.g., cystic fibrosis, eating disorders, urinary retention) 
  • Excessive urge to drink water without feeling thirsty 
  • Syndrome of inappropriate antidiuretic hormone secretion (brain disorder) 
  • Addison’s disease (adrenal gland problem) 
  • Bleeding or clotting problems 

Inform your doctor and pharmacist of all prescription and non-prescription drugs, vitamins, and herbal supplements you are taking to reduce the chance of drug interaction with Nocdurna. 

Some products that may interact with Nocdurna are: 

  • Glucocorticoids (steroids) taken orally or inhaled 
  • Tolvaptan 
  • Diuretics (e.g., furosemide) 

Nocdurna is not advised for treating nocturia in pregnant women. Nocturia during pregnancy is typically a result of normal physiological changes and does not necessitate the use of Nocdurna. 

Before breastfeeding, seek medical advice, as desmopressin can be transmitted through breast milk. 

Additional information

Generic name:



Orally Disintegrating Tablet


25mcg, 50mcg

Quantities Available:


Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Nocdurna (Desmopressin). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Nocdurna (Desmopressin).