Indications 

Orilissa is a medication utilized by women to alleviate moderate to severe pain associated with endometriosis, a condition characterized by the growth of tissue that typically lines the interior of the womb in an alternate location, such as the exterior surface of the uterus, ovaries, or other organs.  

Symptoms of endometriosis may include painful/heavy/irregular menstrual periods, pain during or after sexual intercourse, or infertility.  

Orilissa functions by reducing the body’s production of specific hormones (luteinizing hormone, follicle-stimulating hormone), which leads to a decrease in levels of female sex hormones (estrogens). Lowering these hormone levels may help alleviate some symptoms of endometriosis. 

Uses and Dosage 

Before taking elagolix, carefully read the Medication Guide provided by your pharmacist. If you have any questions or concerns, do not hesitate to ask your doctor or pharmacist for assistance. 

Your doctor may conduct a pregnancy test before starting you on this medication or may advise you to start it within the first 7 days of your menstrual period to ensure that you are not pregnant. Follow your doctor’s instructions when taking this medication. 

Take this medication orally with or without food as directed by your doctor, usually once or twice a day. Your dosage and treatment duration will depend on your medical condition, response to treatment, and other medications you may be taking.  

Inform your doctor and pharmacist about all the products you use, including prescription drugs, nonprescription drugs, and herbal products. To minimize the risk of bone loss, you may need to take this medication for up to 6 to 24 months. Discuss the details with your doctor. 

For optimal results, take this medication regularly at the same time(s) every day. 

Side Effects 

Allergic Reactions

In case of an allergic reaction, seek emergency medical assistance immediately. Signs of allergic reactions may include hives, difficulty breathing, swelling of the face, lips, tongue, or throat. 

Severe Side Effects

Notify your doctor immediately if you experience any of the following: 

• Mood or behavior changes 
• Anxiety, depression, or suicidal thoughts 
• Liver problems such as nausea, vomiting, upper right abdominal pain, fatigue, easy bruising, dark urine, and yellowing of the skin or eyes 

Common Side Effects 

• Hot flashes or night sweats 
• Headaches 
• Nausea 
• Insomnia 
• Altered mood 
• Mood swings 
• Missed menstrual periods 
• Depressed mood 
• Anxiety 
• Joint pain 

Caution 

Prior to taking Orilissa, inform your healthcare provider or pharmacist of any known allergies, including allergies to inactive ingredients present in this product. For more information, consult with your pharmacist. 

Share your medical history with your healthcare provider or pharmacist before using this medication, especially if you have a history of liver problems, mental/mood disorders, or bone loss (osteoporosis). 

Prior to any surgery, notify your doctor or dentist of all medications you’re taking, including prescription drugs, non-prescription drugs, and herbal products. 

Orilissa must not be used during pregnancy, as it may harm the unborn baby. Therefore, it’s important to ask about reliable non-hormonal forms of birth control, such as condoms or spermicide, while using this medication and for four weeks following treatment cessation.