Indications 

Otezla (apremilast) is an oral medication taken twice daily to reduce inflammation in the treatment of specific types of psoriatic arthritis, plaque psoriasis, and Behçet’s disease. 

Otezla works by inhibiting an enzyme in the immune system that can affect certain cells and contribute to inflammation throughout the body. As a member of the phosphodiesterase-4 inhibitor group of medications, Otezla increases the level of cyclic adenosine monophosphate (cAMP), a messenger system in the body, to reduce inflammation. Unlike biologic agents, Otezla is not derived from living organisms. 

Uses and Dosage 

Administer this medication orally, with or without food, according to your physician’s instructions, typically twice a day.  

The manufacturer recommends against crushing, splitting, or chewing the tablet before ingestion. 

The dose is determined by your medical condition and response to treatment. To mitigate the chance of adverse effects, your physician may advise starting with a low dose and gradually increasing it. Carefully follow your physician’s instructions. 

Take this medication regularly to derive the most benefit from it. To help you remember, take it at the same time each day. 

Side Effects 

Allergic Reactions

In case of an allergic reaction to this medication, seek immediate medical attention if you experience symptoms such as hives, difficulty breathing, swelling of the face, lips, tongue, or throat. 

Severe Side Effects

While taking Otezla, some side effects may occur, and you should contact your doctor promptly if you experience any of the following: 

• Severe diarrhea, nausea, and vomiting 
• Unexplained weight loss or significant weight loss 
• Mood changes, new or worsening depression 
• Thoughts of suicide or self-harm 

Common Side Effects  

• Nausea and diarrhea 
• Headache 
• Cold symptoms, such as stuffy nose, sneezing, or sore throat 

Please note that this list is not comprehensive, and other side effects may occur. Contact your doctor if you experience any unusual symptoms while taking this medication. 

Caution 

Prior to taking Otezla, inform your healthcare provider or pharmacist of any allergies you may have, including allergies to this medication. This product may contain inactive ingredients that could potentially trigger allergic reactions or other issues, discuss this further with your pharmacist. 

Before starting treatment with apremilast, be sure to disclose your medical history to your healthcare provider or pharmacist, especially if you have a history of kidney disease or mental/mood disorders such as depression. 

If you are planning to have surgery, be sure to inform your doctor or dentist about all medications, including prescription drugs, nonprescription drugs, and herbal products, that you are currently taking. 

If you are pregnant, weigh the benefits and risks of using apremilast with your healthcare provider. It should only be used during pregnancy if clearly necessary. For additional information or questions about this medication, please consult with your pharmacist or physician.