Periostat (Doxycycline Hyclate) Medication


Periostat (Doxycycline Hyclate)

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Drug Description


Periostat is a prescription medicine used alongside scaling and root planing to help improve tooth attachment levels and reduce gum pocket depth in adults with periodontal disease (gum disease).  

Periostat is a type of antibiotic called tetracycline, but it does not treat bacterial infections. Instead, its mechanism of action involves inhibiting collagenase activity, which helps prevent the breakdown of gum tissue. 

Uses and Dosage 

Before taking Periostat and with each prescription refill, carefully review its medication guide and patient information leaflet. Ask your healthcare provider if you have any questions or concerns. 

The dosage of Periostat varies from that of doxycycline for treating infections. Going beyond the recommended dosage may lead to more side effects, such as the emergence of resistant microorganisms. Adhere strictly to your doctor’s prescription. 

Typically, Periostat is taken twice daily with a 12-hour gap (morning and evening) on an empty stomach (at least 1 hour before or 2 hours after a meal) as directed by the doctor. 

This medication should be taken with a full glass of water unless otherwise directed to facilitate ingestion and minimize the potential for esophageal irritation and ulceration. 

For optimal results, take this medication at a consistent time each day at evenly spaced intervals. Take it exactly as directed, and refrain from making any changes to the dosage, frequency, or duration of use without obtaining approval from your doctor. 

Side Effects 

Listed below are the potential adverse effects of Periostat. If any of them last or worsen, notify your doctor promptly. 

Common Side Effects 

  • Severe headache 
  • Dizziness 
  • Blurred vision 
  • Nausea 
  • Diarrhea 
  • Upset stomach 
  • Skin rash or itching 
  • Vaginal itching or discharge 

Serious Side Effects 

  • Sunburn due to sun sensitivity 
  • Painful or difficult swallowing 
  • Change in urine volume 

Tell your doctor immediately if you experience any of the severe side effects listed above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Periostat may occur. Seek immediate medical assistance if any signs of a serious allergic reaction are observed, such as: 

  • Persistent fever 
  • New or worsening swelling of lymph nodes 
  • Rash 
  • Itching or swelling, particularly of the face, tongue, or throat 
  • Severe dizziness 
  • Difficulty breathing 

Not all side effects of Periostat are included in this list. Inform your physician right away if any unlisted effects occur. 


Before starting treatment with Periostat, inform your doctor of any known allergies, particularly to doxycycline, other tetracyclines (e.g., minocycline), or other medications. 

Consult your pharmacist for further information, as Periostat may contain inactive substances that could potentially trigger allergies or other complications. 

To ensure Periostat is safe for you, disclose to your physician your medical background, especially if you have a history of: 

  • Difficulty swallowing 
  • Esophagus issues (e.g., hiatal hernia or reflux/heartburn) 

Inform all your healthcare providers about any current or newly initiated or discontinued medications, including prescription and non-prescription drugs, vitamins, and herbal supplements, to lower the risk of drug interaction with Periostat. 

Some of the medications that may interact with Periostat include: 

  • Oral retinoid medications (e.g., acitretin, isotretinoin) 
  • Barbiturates (e.g., phenobarbital) 
  • Blood thinners (e.g., warfarin) 
  • Digoxin 
  • Anti-seizure medications (e.g., phenytoin) 
  • Strontium 

To ensure optimal absorption of Periostat, take it 2 to 3 hours before or after consuming any products containing aluminum, calcium, iron, magnesium, zinc, or bismuth subsalicylate. Examples of such products include: 

  • Antacids 
  • Didanosine solution 
  • Quinapril 
  • Vitamins/minerals 
  • Dairy products like milk and yogurt 
  • Calcium-enriched juice  

The above-listed substances bind with Periostat, limiting its absorption by the body. 

Inform your healthcare provider of your use of Periostat prior to receiving any immunizations, as this medication may compromise the effectiveness of live bacterial vaccines, such as the typhoid vaccine. 

Periostat can potentially affect specific laboratory tests, including urine catecholamine levels, leading to inaccurate results. Inform laboratory personnel and all your doctors about your use of this medication. 

Periostat may increase sun sensitivity. Take precautions by limiting sun exposure, avoiding tanning booths and sunlamps, and using sunscreen and protective clothing when going outdoors. Promptly inform your doctor if you experience sunburn or develop skin blisters or redness. 

Inform your doctor of your pregnancy status or intention to conceive. Taking Periostat during pregnancy is not recommended as it may pose a risk to the unborn baby. If you become pregnant, promptly consult your doctor to discuss the potential risks and benefits associated with this medication. 

Doxycycline can be excreted into breast milk and can potentially impact bone and tooth development in nursing infants. Breastfeeding while taking this medication is not recommended. 

Additional information

Generic name:

Doxycycline Hyclate





Quantities Available:

60, 120, 180

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Periostat (Doxycycline Hyclate). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Periostat (Doxycycline Hyclate).