Polysporin Pain Relief (Bacitracin Zinc/Polymyxin B Sulfate - non Rx) Medication


Polysporin Pain Relief (Bacitracin Zinc/Polymyxin B Sulfate - non Rx)

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Drug Description


Polysporin Pain Relief is a cream medication indicated to prevent or treat infection. It helps to reduce pain and discomfort associated with injury or infection. Note the cream is not effective against fungal infections and should not be used on acne or pimples. 

The cream contains Bacitracin Zinc and Polymyxin B Sulfate. The Bacitracin Zinc component works by interfering with the formation of the bacterial cell wall, while the Polymyxin B Sulfate component works by damaging the bacterial cell membrane. The combinations of antibiotics create a barrier that helps prevent infection and promotes wound healing.  

Use and Dosage 

The cream is typically applied directly to the affected area, and the length of treatment will depend on the severity of the injury or infection. The instructions for using Polysporin Pain Relief Cream, are as follows: 

  1. Wash your hands thoroughly before using the cream. 
  2. Clean the affected area with mild soap and water and pat dry. 
  3. Apply a small amount of the cream to the affected area, up to 3 times a day. 
  4. Cover the area with a sterile bandage if desired. 
  5. Wash your hands again after applying the cream. 

Apply the cream exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.  

Note that the specific instructions for using Polysporin Pain Relief cream may vary depending on the product and its intended use. As always, follow the instructions carefully and consult with a healthcare provider if you have any questions or concerns. 

Side Effects 

Common Side Effects 

  • Skin irritation 
  • Rash 
  • Itching 
  • Redness 
  • Swelling 

Serious Side Effects 

  • Acne-like rash 
  • Allergic reaction (difficulty breathing, hives, swelling of the face, lips, tongue, or throat) 
  • Increased hair growth 
  • Severe itching or burning 
  • Skin thinning or discoloration 
  • Stretch marks 


  • The Pain Relief Cream can cause an allergic reaction in some people. If you have a history of allergic reactions to antibiotics, you should consult with your doctor before using the cream.  
  • Overuse of topical antibiotics like Polysporin may lead to antibiotic resistance, which can make it harder to treat infections in the future.  
  • The Cream should not be used on deep or puncture wounds, animal bites, or serious burns, as these types of injuries may require medical attention. 
  • If you experience any signs of an allergic reaction, such as hives, difficulty breathing, or swelling of the face or throat, discontinue the use of the Cream and seek medical attention immediately. 
  • The Cream is meant for external use only and should not be ingested or used in the eyes or mouth. 
  • Some people may experience skin irritation or a rash when using it. If this occurs, discontinue use, and consult with a healthcare provider. 
  • The cream can interact with other medications or medical conditions, so talk to a healthcare provider before using these creams if you have any medical conditions or are taking any other medications. 
  • It should not be used for more than seven days unless directed by a healthcare provider. If symptoms do not improve or worsen after using the cream, seek medical attention. 
  • It should be kept out of reach of children and pets to prevent accidental ingestion. 

Additional information

Generic name:

Bacitracin Zinc/Polymyxin B Sulfate – non Rx





Quantities Available:

15g, 30g

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Polysporin Pain Relief (Bacitracin Zinc/Polymyxin B Sulfate - non Rx). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Polysporin Pain Relief (Bacitracin Zinc/Polymyxin B Sulfate - non Rx).