Indications 

Prednisolone is a corticosteroid that exhibits potent anti-inflammatory and immunosuppressive properties. By simulating the activity of cortisol, a hormone naturally produced by the adrenal glands to regulate metabolism and stress, Prednisolone serves to mitigate inflammatory responses and curb the overactivity of the immune system.  

This medication effectively curbs the release of substances in the body responsible for eliciting inflammation, rendering it a versatile agent in the management of a wide array of inflammatory conditions, including arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, glandular disorders, and various dermatologic, pulmonary, neurologic, and hematologic conditions. 

Prednisolone’s glucocorticoid activity predominates over its mineralocorticoid activity, meaning its mechanism of action primarily targets the immune response and inflammation without interfering with the body’s electrolyte and water balance. 

Uses and Dosage 

To ensure optimal therapeutic benefit, take this medication orally with food or milk to avoid gastric irritation, as directed by your physician. Unless instructed otherwise, consume a full glass of water (8 ounces/240 milliliters) along with your medication. 

Comply with the dosing schedule meticulously, as the prescribed dose and duration of treatment depend on your medical condition and response to the medication. Your healthcare provider may recommend prednisolone administration 1 to 4 times per day or instruct you to take a single dose every other day.  

To enhance adherence to the prescribed regimen, consider marking your calendar or utilizing a pillbox. If using the prednisolone dose pack, adhere to the dosing schedule as indicated on the package, unless otherwise advised by your physician. 

Discontinuation of prednisolone therapy should only be undertaken after consulting your healthcare provider, as abrupt cessation may exacerbate certain medical conditions. Your dosage may need to be gradually reduced to minimize the risk of withdrawal symptoms, such as muscle pain, headache, weight loss, dizziness, weakness, tiredness, or nausea.  

Withdrawal symptoms are more likely to occur after prolonged or high-dose prednisolone administration. Notify your doctor or pharmacist immediately if you experience withdrawal symptoms. Refer to the Precautions section for further guidance. 

Side Effects 

Allergic Reactions

Seek immediate medical assistance if you develop an allergic reaction to prednisolone, which may include; 

• Hives 
• Difficulty breathing 
• Swelling of the face, lips, tongue, or throat 

Severe Side Effects

Prednisolone may result in severe side effects that require prompt medical attention. Contact your physician immediately if you experience any of the following symptoms: 

• Shortness of breath, swelling, or rapid weight gain 
• Bruising, thinning skin, or a non-healing wound 
• Severe depression, personality changes, unusual thoughts or behavior 
• New or unusual pain in an arm, leg, or back 
• Bloody or tarry stools, coughing up blood, or vomit resembling coffee grounds 
• Upper abdominal pain that is severe and spreads to your back, accompanied by nausea and vomiting 
• A seizure (convulsions) 
• Low potassium levels that manifest as:
  • Leg cramps
  • Constipation
  • Irregular heartbeats
  • Chest fluttering
  • Increased thirst
  • Urination
  • Numbness/tingling

If your child is taking prednisolone and not growing at a normal rate, notify the doctor as steroids may affect growth. 

Common Side Effects  

• Swelling in the hands or ankles due to fluid retention 
• Dizziness or spinning sensation 
• Changes in menstrual periods 
• Headache 
• Muscle pain or weakness 
• Stomach discomfort or bloating. 

Caution 

Before taking prednisolone, disclose to your healthcare provider if you have an allergy to prednisolone, prednisone, or any other allergies. This product may contain inactive ingredients that can lead to an allergic reaction or other complications. Consult your pharmacist for more information. 

Before using this medication, discuss your medical history with your healthcare provider, particularly if you have; 

• Eye disease such as glaucoma or cataracts  
• Heart problems such as heart attack or heart failure 
• High blood pressure 
• Liver disease 
• Kidney disease 
• Thyroid problems 
• Diabetes 
• Stomach or intestinal problems such as ulcer or diverticulitis 
• Brittle bones such as osteoporosis 
• Current or past infections such as tuberculosis 
• Herpes 
• Fungal infections or a positive tuberculosis test 
• Bleeding problems 
• Blood clots 
• Mental or mood conditions such as anxiety, depression, or psychosis 
• Low levels of salts in the blood such as low potassium or calcium 

This medication can make you feel dizzy. Consumption of alcohol or marijuana can increase dizziness. Do not operate machinery or drive or engage in any activities that require vigilance until you feel alert. Limit alcohol intake and discuss with your doctor if you use marijuana. 

Before undergoing surgery, notify your doctor or dentist of all the products you are taking, including prescription drugs, non-prescription drugs, and herbal products. 

Inform your healthcare professional that you are taking prednisolone before receiving any immunizations or vaccinations. Avoid contact with individuals who have recently received live vaccines, such as the flu vaccine administered through the nose.