Prempro Low Dose (Medroxyprogesterone/Estrogen) Medication


Prempro Low Dose (Medroxyprogesterone/Estrogen)

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Drug Description


This pharmaceutical preparation comprises two key hormonal components: estrogen (such as conjugated estrogen or estradiol) and progestin (medroxyprogesterone, norethindrone, or norgestimate). Specific brand formulations may incorporate progesterone as opposed to progestin. Both progesterone and progestin emulate the biological actions of naturally occurring progesterone within the body. The primary purpose of this medication is to alleviate menopausal symptoms in women, including but not limited to hot flashes and vaginal dryness, which result from a decrease in endogenous estrogen production. Furthermore, including progestin or progesterone in this medication serves the critical function of mitigating the risk of uterine cancer associated with estrogen therapy. 

Uses and Dosage 

Administer this medication orally by your healthcare provider’s instructions, typically once daily, either with or without food. To minimize the potential for stomach discomfort, take it alongside a meal or shortly after eating. 

The prescribed dosage is contingent upon your medical condition and response to the treatment regimen.  

For optimal therapeutic outcomes, adhere to a consistent schedule of medication intake. To facilitate adherence, establish a routine time for daily consumption and comply diligently with your prescribed dosing regimen. Under no circumstances should you augment the dosage or extend the duration of treatment beyond the recommended guidelines provided by your healthcare professional. 

Side Effects 

Possible side effects of this medication may encompass:  

  • Stomach upset 
  • Nausea/vomiting 
  • Bloating 
  • Breast tenderness 
  • Headache 
  • Weight fluctuations 

If these side effects persist or worsen, promptly inform your healthcare provider or pharmacist. 

Recognize that your physician has prescribed this medication after assessing the potential benefits outweigh the associated risks. Many individuals using this medication do not experience severe side effects. 

If there are any severe or concerning side effects, promptly notify your healthcare provider. These may include:  

  • Persistent nausea/vomiting 
  • Alterations in mental or emotional well-being, such as:  
    • Depression 
    • Memory impairment 
  • Detection of breast lumps 
  • Unusual vaginal bleeding, such as:  
    • Spotting 
    • Breakthrough bleeding 
    • Prolonged/recurrent bleeding 
  • Heightened or novel vaginal irritation/itching/odor/discharge 
  • Severe abdominal or stomach pain 
  • Jaundice (characterized by yellowing of the eyes or skin) 
  • Darkened urine 
  • Swelling in the extremities (hands/ankles/feet) 
  • Increase in thirst or urination 


Before commencing this medication, apprise your healthcare provider or pharmacist of any known allergies, whether to this medication itself or other substances. This product may incorporate inactive components capable of eliciting allergic reactions or other adverse effects, and your pharmacist can offer further insights on this matter. 

Furnish your healthcare provider or pharmacist with a comprehensive medical history, with particular emphasis on the following:  

  • Instances of unexplained vaginal bleeding 
  • History of specific cancers (including breast, uterine, or ovarian cancer) 
  • Previous occurrences of blood clots 
  • Stroke  
  • Heart conditions (such as myocardial infarction) 
  • Liver disorders 
  • Kidney ailments 
  • Familial medical history (particularly concerning breast abnormalities, cancer, or blood clotting issues) 
  • Personal or familial antecedents of angioedema (a specific swelling disorder) 
  • Clotting disorders (such as protein C or protein S deficiency) 
  • Hypertension 
  • Diabetes 
  • Elevated levels of blood cholesterol/triglycerides 
  • Obesity 
  • Lupus 
  • Hypothyroidism (underactive thyroid) 
  • Imbalances in mineral levels (low or high calcium levels in the blood) 
  • Specific hormone-related conditions (hypoparathyroidism) 
  • Uterine conditions (e.g., fibroids or endometriosis) 
  • Gallbladder disease 
  • Asthma 
  • Seizures 
  • Migraines 
  • Specific hematological disorders (like porphyria)  
  • Mental or mood disorders (such as dementia or depression) 

Furthermore, inform your doctor if you have recently undergone surgery or are planning to undergo surgery shortly or if you anticipate being immobile for extended periods (e.g., prolonged air travel). These circumstances heighten the risk of developing blood clots, especially when employing an estrogen-containing product. Consequently, it may be necessary to discontinue this medication temporarily or undertake special precautions in such scenarios. 

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Prempro Low Dose (Medroxyprogesterone/Estrogen). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Prempro Low Dose (Medroxyprogesterone/Estrogen).