Proamatine (Midodrine) Medication

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Proamatine is a prescribed medication indicated for the treatment of orthostatic hypotension (OH), a condition characterized by a sudden drop in blood pressure upon transitioning from a seated or lying position to standing. 

This medication is recommended only for patients with significantly impaired lives, even after receiving standard clinical care, including non-pharmacologic treatment (such as support stockings), fluid expansion, and lifestyle changes. 

Classified as an alpha-adrenergic agonist, Proamatine works by constricting blood vessels, thereby raising blood pressure. 

Uses and Dosage 

Before taking Proamatine and with each prescription refill, carefully review its medication guide and patient information leaflet. If you have any queries, seek clarification from your healthcare provider or pharmacist. 

Proamatine dosage is determined based on individual medical conditions and response to the treatment.  

Your physician will likely initiate this medication at a low dosage and gradually adjust it to minimize potential side effects. Adhere to your physician’s instructions carefully. 

Typically, Proamatine is taken three times a day during daytime hours (ideally in the morning upon waking, midday, and late afternoon (no later than 6 P.M.). It can be taken with or without food, with a minimum gap of 3 to 4 hours between doses. 

For optimal results, take this medication around the same time each day.  

Avoid taking this medicine after the evening meal or less than 4 hours before bedtime. Similarly, do not take your dose if you anticipate an extended period of lying down, such as napping.  

Inform your doctor if your condition persists or worsens. Proamatine should be continued solely for individuals whose symptoms show improvement during the course of treatment. 

Side Effects 

Listed below are the potential adverse effects of Proamatine. If any of them last or worsen, inform your doctor right away. 

Common Side Effects 

  • Chills, goosebumps 
  • Numbness, tingling, or itching (particularly in the scalp) 
  • Headache, dizziness, fatigue 
  • Nausea 
  • Increased urination, painful or difficult urination, or sudden urge to urinate 

Serious Side Effects 

  • Severely slowed heart rate:  
    • Weak pulse 
    • Severe dizziness 
    • Feeling light-headed 
  • Dangerously high blood pressure:  
    • Severe headache 
    • Pounding sensation in the ears (hearing heartbeats) 
    • Blurred vision 
    • Buzzing in the ears 
    • Anxiety 
    • Confusion 
    • Chest pain 
    • Shortness of breath 
    • Uneven heartbeats 
    • Seizure 

Stop taking Proamatine and call your doctor right away if you encounter any severe adverse reactions. 

Allergic Reactions 

Although rare, a severe allergic reaction to Proamatine may occur. Prompt medical assistance must be sought if any of the following signs of severe allergic reactions are noticed:  

  • Hives 
  • Difficult breathing 
  • Swelling (face, lips, tongue, or throat) 

Not all side effects of Proamatine are included in this list. Notify your healthcare provider if any unlisted effects are observed. 


Before starting treatment with Proamatine, inform your doctor if you have any known allergies, particularly to midodrine and other medications. 

Consult your pharmacist for more information, as Proamatine may contain inactive components that may trigger allergic reactions or other complications. 

To ensure Proamatine is safe for you, disclose to your physician your medical background, especially if you have a history of: 

  • High blood pressure 
  • Pheochromocytoma 
  • Overactive thyroid (hyperthyroidism) 
  • Difficulty urinating (caused by urinary retention or enlarged prostate) 
  • Heart disease 
  • Liver disease 
  • Kidney disease 
  • Diabetes 

Inform all your healthcare providers about any current, newly initiated, or discontinued medications, including prescription and non-prescription drugs, vitamins, and herbal supplements, to prevent potential drug interaction with Proamatine. 

Certain products contain ingredients that may increase your blood pressure. Inform your pharmacist if you are currently using cough-and-cold products, diet aids, or NSAIDs like ibuprofen/naproxen, and seek guidance on how to use them safely. 

The use of Proamatine during pregnancy should only be considered if the potential benefits outweigh the potential risks to the fetus. 

The potential transfer of midodrine into breast milk and its effects on nursing infants are currently unknown. If you are breastfeeding, inform your doctor about it. 

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Proamatine (Midodrine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Proamatine (Midodrine).