Retin-A Gel (Tretinoin) Medication


Retin-A Gel (Tretinoin)

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Table of contents:

Drug Description


Retin-A Gel is a topical medication prescribed for the treatment of acne vulgaris. 

Classified as a retinoid, Retin-A Gel modulates skin cell growth, potentially reducing the occurrence and severity of acne pimples while expediting the healing process of existing ones. 

Uses and Dosage 

Before using Retin-A Gel and with each prescription refill, carefully review its medication guide and patient information leaflet. Should you have any uncertainties, consult your doctor or pharmacist. 

Retin-A Gel is intended for external use only. Avoid applying it to the inner lip area, inside the nose or mouth, as well as on any cuts, scrapes, sunburns, or areas affected by eczema. 

Typically, this medication is applied once daily at bedtime to the skin where acne lesions are present. 

To properly apply this gel, follow these steps: 

  1. Wash your hands thoroughly before applying the gel. 
  2. Use a mild or soapless cleanser to gently clean the affected skin, then pat it dry. 
  3. Wait 20 to 30 minutes to ensure the skin is completely dry to reduce the risk of potential irritation. 
  4. Following your doctor’s instructions, apply a small amount of gel (approximately the size of a pea) using your fingertips, and spread it in a thin layer. 
    • Avoid contact with your eyes; if the medication comes into contact with them, immediately flush them with ample water. Should any eye irritation develop, contact your doctor. 
  5. After applying the gel, remember to wash your hands to prevent accidental eye contact. 

For optimal results, use this medication exactly as directed, around the same times each day. Avoid exceeding the recommended amount or frequency of use, as it will not expedite skin improvement and may heighten the likelihood of experiencing redness, peeling, and pain. 

Side Effects 

Listed below are the potential adverse effects of Retin A- Gel. If any of them last or get worse, promptly notify your doctor. 

Common Side Effects 

  • Warmth or stinging after application. 
  • Skin redness, dryness, itching, or scaling 
  • Mild burning sensation 
  • Temporary worsening of acne during the initial 2 to 4 weeks of usage 

Serious Side Effects 

  • Blistering or crusting of the skin 
  • Severe burning or swelling of the skin 
  • Skin discoloration 

Inform your doctor immediately if you experience any of the serious side effects above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Retin-A Gel may occur. Seek medical help right away if you experience indications of an allergic reaction, such as: 

  • Rash,  
  • Face, tongue, or throat itching/swelling 
  • Severe dizziness 
  • Trouble breathing 

Not all side effects of Retin-A Gel are included in this list. Inform your doctor right away if any unlisted effects are experienced. 


Before using Retin-A Gel, inform your doctor if you have any known allergies, particularly to tretinoin or other medications. 

Consult your pharmacist for more information about Retin-A Gel, as it may contain inactive ingredients that may cause allergic reactions or other complications. 

To ensure Retin-A Gel is safe for you, disclose to your physician your medical background, especially if you have a history of eczema. 

Inform all your healthcare providers about any current or newly initiated or discontinued medications, including prescription and non-prescription drugs, vitamins, and herbal supplements, to reduce the risk of drug interaction with Retin-A Gel. 

Refrain from using skin products that have the potential to be harsh, irritating, or drying on the treated area. Examples of such products are: 

  • Hair perming solutions 
  • Alcohol lime menthol-containing products (e.g., astringents, toners, shaving lotion) 
  • Medicated or abrasive soaps or cleansers, soaps, and cosmetics with a strong drying effect (e.g., alpha hydroxy acids, glycolic acid) 
  • Products containing sulfur, resorcinol, or salicylic acid 

Exercise caution when using Retin-A Gel if you recently used sulfur, resorcinol, or salicylic acid products. Wait until the effects of these products on your skin have diminished before applying Retin-A Gel. 

Consult your healthcare provider or pharmacist to ensure the proper usage of prescription and over-the-counter benzoyl peroxide products, as their concurrent application with Retin-A Gel can lead to irritation and reduced effectiveness. 

Retin-A Gel may heighten the skin’s susceptibility to sunlight or ultraviolet light. Limit unnecessary or extended exposure to sunlight or ultraviolet light (such as tanning beds and sunlamps) and adopt protective measures like wearing suitable clothing, sunglasses, and sunscreen. 

Minimize prolonged exposure to wind or cold, as extreme climates can dry or irritate normal skin. Skin treated with Retin- A Gel may become more sensitive to such conditions. Consult your physician for guidance on managing your acne treatment in these circumstances. 

Retin-A Gel is flammable. Avoid using it near an open flame or while smoking. 

Using Retin-A Gel during pregnancy may risk harm to the unborn baby. Promptly inform your healthcare provider if you are pregnant or become pregnant while using this gel. 

The transfer of tretinoin into breast milk is uncertain. Before breastfeeding, consult your doctor for guidance. 

Additional information

Generic name:





0.025%, 0.10%

Quantities Available:

30 grams, 40 grams, 60 grams, 90 grams, 100 grams

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Retin-A Gel (Tretinoin). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Retin-A Gel (Tretinoin).