Salazopyrin EC (Sulfasalazine) Medication


Salazopyrin EC (Sulfasalazine)

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Generic Alternative - Salazopyrin EC (Sulfasalazine)

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Table of contents:

Drug Description


Salazopyrin EC, also known as sulfasalazine, is a medication that is used to treat inflammatory bowel disease (such as ulcerative colitis and Crohn’s disease) and rheumatoid arthritis. It can reduce the numbers of white blood cells in the body, which helps to decrease the activity of the immune system. 

Salazopyrin is classified as a disease-modifying anti-rheumatic drug (DMARD) and works by reducing inflammation in the body. It inhibits the production of certain chemicals in the body that contribute to inflammation.  

Use and Dosage 

Salazopyrin Delayed Release Tablets should be swallowed whole with a glass of water. Do not crush, break, or chew the tablets unless instructed otherwise by your healthcare provider. The tablet can be taken with or without food. However, take them with food to help minimize stomach upset. Follow the instructions provided by your healthcare provider or the medication’s packaging.  

The duration of treatment with it will depend on your specific condition and response to the medication. Typically, the initial dose for adults is 2 to 4 grams per day, divided into multiple doses. The dose may be increased or decreased based on individual response and tolerability. For children, the dosage is based on body weight. Follow your healthcare provider’s instructions regarding the duration of treatment. Take the medication at the same time(s) every day to maintain a consistent level of the medication in your body. It is important to follow the prescribed schedule. 

If you accidentally miss a dose of Salazopyrin EC, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any concerns or questions, consult your healthcare provider. 

Side Effects 

Common Side Effects 

  • Anorexia 
  • Gastric distress 
  • Headache 
  • Nausea 
  • Reversible oligospermia 
  • Vomiting 

Serious Side Effects  

  • Cyanosis 
  • Fever 
  • Heinz body anemia 
  • Hemolytic anemia 
  • Pruritus 
  • Skin rash 
  • Urticaria 


  • If you are allergic to sulfasalazine, sulfa drugs, aspirin, related drugs (salicylates), or mesalamine, you should inform your doctor or pharmacist before taking Sulfasalazine. 
  • If you have significant kidney or liver problems, you should exercise caution when taking Sulfasalazine. Your doctor may need to adjust the dosage or monitor your liver and kidney function regularly. 
  • Salazopyrin EC should be used with caution if you have porphyria, which is a rare blood pigment disorder. Discuss this condition with your doctor before starting the medication. 
  • If you have G6PD (glucose-6-phosphate dehydrogenase) deficiency, a condition where your red blood cells break down when exposed to certain foods, drugs, infections, or stress, you should exercise caution when taking Sulfasalazine.  
  • Salazopyrin EC is not recommended during pregnancy, especially in the first trimester. Discuss the potential risks and benefits with your doctor if you are trying to get pregnant, are pregnant, or breastfeeding. While small amounts of sulfasalazine may pass into breast milk, it is unlikely to cause significant side effects in the baby. However, monitor your baby for any unusual symptoms and consult with your healthcare provider. 
  • Sulfasalazine may interact with other medications. Inform your doctor or pharmacist about all the medications you are taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Specific caution should be exercised when taking digoxin, a medication for heart problems, along with Salazopyrin EC. 
  • Salazopyrin EC may affect blood cell production and can cause blood disorders such as agranulocytosis (a decrease in white blood cells), aplastic anemia (a decrease in all types of blood cells), or hemolytic anemia (destruction of red blood cells). If you experience symptoms like unexplained bruising, bleeding, persistent sore throat, or signs of infection, you should seek immediate medical attention. 
  • Sulfasalazine can affect blood sugar levels and require monitoring in individuals with diabetes. Your doctor may need to adjust your diabetes medication or insulin dosage, as necessary. 
  • Sulfasalazine can increase sensitivity to sunlight or ultraviolet (UV) light. Use sunscreen, wear protective clothing, and limit sun exposure while taking the tablet. 
  • Salazopyrin EC may affect male fertility. If you are trying to conceive, discuss the tablet with your doctor. If you have an upcoming surgery, inform your surgeon or anesthesiologist that you are taking Salazopyrin EC, as it may interact with certain medications used during surgery.  

Additional information

Generic name:



Delayed Release Tablet, EC Tablet



Quantities Available:


Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Salazopyrin EC (Sulfasalazine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Salazopyrin EC (Sulfasalazine).