Salofalk Enema (Mesalamine) Medication


Salofalk Enema (Mesalamine)

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Drug Description


Salofalk Enema is a prescription medication used to treat inflammatory bowel disease, specifically ulcerative colitis. It is effective in treating mild to moderate forms of ulcerative colitis, including proctitis (inflammation of the rectum) and left-sided colitis.  

Salofalk Enema works by reducing inflammation in the lining of the rectum and colon. The active ingredient, mesalamine, is an aminosalicylate anti-inflammatory agent that acts locally on the inflamed tissue. It helps to relieve the symptoms of ulcerative colitis, such as rectal bleeding, diarrhea, and abdominal pain. 

Salofalk Enema is administered rectally and is used to control the symptoms of ulcerative colitis, but it does not cure the condition. It is also not effective for treating Crohn’s disease, another form of IBD that can affect any part of the digestive tract. 

Use and Dosage 

Salofalk Enema is administered rectally. The usual dose is one enema (4 grams) once daily, preferably at bedtime. The enema should be retained in the bowel for at least 1 to 3 hours, or as directed by your healthcare provider. 

To use Salofalk Enema, follow these steps: 

  1. Make sure you are in a comfortable position, such as lying on your left side or in the knee-chest position. 
  2. Shake the enema bottle well before use to ensure proper mixing of the medication. 
  3. Remove the protective cover from the applicator tip. 
  4. Gently insert the applicator tip into the rectum. If needed, you can use a water-based lubricant to help with insertion. 
  5. Slowly squeeze the bottle to release the enema medication into the rectum. Apply steady pressure to ensure that most of the enema is discharged. 
  6. Once the enema is administered, remove the applicator from the rectum while continuing to squeeze the bottle. 
  7. Remain in the same position for a few minutes to allow the medication to distribute within the rectum. Use the enema at bedtime to allow for a longer retention time. 
  8. After using the enema, wash your hands thoroughly with soap and water. 
  9. Dispose of the enema bottle and any unused medication as per the instructions provided. 

If you miss a dose of Salofalk Enema, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. 

Side Effects 

Common Side Effects  

  • Abdominal pain 
  • Diarrhea 
  • Flatulence 
  • Hair loss 
  • Headache 
  • Nausea and vomiting 
  • Rash 
  • Worsening of ulcerative colitis 

Serious Side Effects 

  • Abnormal sensations in the body (numbness or weakness in the arms or legs) 
  • Allergic reaction 
  • Blood problems including low platelets, low red blood cells and low white blood cells leading to infection, tiredness, and easy bruising 
  • Dizziness 
  • Fever, feeling generally unwell and tired 
  • Impaired hearing 
  • Inflammation of bodily organs (pancreas, colon, liver, muscle, heart) 
  • Joint inflammation leading to joint pain and swelling 
  • Lung side effects such as spasm of the windpipes in the lungs 
  • Skin problems including sensitivity to sunlight, allergic reaction 


  • Hypersensitivity or Allergic Reactions: Some individuals may be hypersensitive or allergic to mesalazine or other ingredients in Salofalk Enema. Inform your healthcare provider if you have a history of allergies or hypersensitivity to mesalazine or any other medications. 
  • Renal Impairment: Salofalk Enema is primarily eliminated through the kidneys. Individuals with impaired renal function may require dose adjustments or close monitoring when using Salofalk Enema. 
  • Hepatic Impairment: Salofalk Enema should be used with caution in individuals with liver disease or impaired liver function. Your healthcare provider will assess the risks and benefits of using Salofalk Enema in these situations. 
  • Blood Disorders: Salofalk Enema may affect blood cell counts, including white blood cells, red blood cells, and platelets. Regular monitoring of blood cell counts may be necessary, especially in individuals with pre-existing blood disorders. 
  • Gastrointestinal Disorders: Salofalk Enema may worsen certain gastrointestinal conditions, such as pyloric stenosis or intestinal obstruction.  
  • Interactions with Other Medications: Salofalk Enema may interact with other medications, such as azathioprine or mercaptopurine, which are commonly used in the treatment of inflammatory bowel disease.  
  • Pregnancy and Breastfeeding: The use of Salofalk Enema during pregnancy and breastfeeding should be carefully considered and discussed with your healthcare provider.  
  • Mesalamine Hypersensitivity Syndrome: Although rare, mesalamine hypersensitivity syndrome has been reported with the use of Salofalk Enema. Signs of this syndrome may include fever, rash, diarrhea, and abdominal pain.  
  • Asthma: Salofalk Enema should be used with caution in individuals with a history of asthma.  
  • Kidney Stones: Mesalamine can increase the risk of kidney stones in some individuals. If you have a history of kidney stones or are at an increased risk, your healthcare provider may monitor your kidney function and provide appropriate recommendations. 
  • Ulcerative Colitis Complications: Salofalk Enema is primarily indicated for the treatment of mild to moderate ulcerative colitis. If you have severe or complicated ulcerative colitis, your healthcare provider may consider alternative treatment options or additional therapies. 
  • Monitoring and Regular Check-ups: Regular monitoring of your condition and periodic check-ups with your healthcare provider are important while using Salofalk Enema.  

Additional information

Generic name:



Enema, Enema Kit


2g/60mL, 4g/60mL

Quantities Available:

7, 28

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Salofalk Enema (Mesalamine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Salofalk Enema (Mesalamine).