Savaysa (Edoxaban Tosilate) Medication


Savaysa (Edoxaban Tosilate)

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Drug Description


Savaysa is a prescribed medication indicated for the prevention of strokes or blood clots in individuals with non-valvular atrial fibrillation (irregular heartbeat). 

Savaysa is also indicated for treating blood clots in the legs (deep vein thrombosis DVT) or lungs (pulmonary embolism PE) in individuals who have undergone 5 to 10 days of treatment with injectable blood thinner medication. 

As a factor Xa inhibitor, Savaysa functions by inhibiting a specific natural substance that facilitates the formation of blood clots. 

Uses and Dosage 

Before starting treatment with Savaysa and with each prescription refill, carefully review its medication guide and patient information leaflet. Should you have any concerns, seek advice from your doctor or pharmacist. 

The dosage of Savaysa is determined based on the patient’s medical condition, weight, response to the treatment, and concurrent medications. 

Typically, this medication is taken once a day as prescribed by the doctor, without regard to food intake. 

Individuals who struggle to swallow the tablet can crush it and combine it with 2 to 3 ounces (60 to 90 milliliters) of water or applesauce. The entire mixture must be consumed immediately and avoid preparing a batch for later use. 

If administering this medication through a gastric tube, consult your healthcare professional for precise guidelines on correct preparation and administration. 

For optimal results, take Savaysa exactly as directed at around the same time(s) daily. Do not alter the prescribed dosage, frequency, and duration of intake without your doctor’s approval. 

Refrain from discontinuing this medication without consulting your doctor, as abruptly stopping the drug may exacerbate certain conditions. 

Side Effects 

Listed below are the potential adverse effects of Savaysa. Tell your doctor right away if any of them persists or worsens. 

Common Side Effects 

  • Bleeding 
  • Low red blood cell (anemia) symptoms: 
    • Pale skin 
    • Unusual tiredness 
    • Feeling light-headed or short of breath 
    • Cold hands and feet 

Serious Side Effects 

  • Easy bruising or bleeding (e.g., nosebleeds, bleeding gums, heavy menstrual bleeding) 
  • Pain, swelling, or drainage from a wound or injection site 
  • Persistent bleeding from wounds or injections 
  • Headaches, dizziness, weakness, or faintness 
  • Red, pink, or brown-colored urine 
  • Bloody or tarry stools 
  • Coughing up blood or vomit resembling coffee grounds 

Call your doctor right away if you encounter any of the serious side effects mentioned above. 

Seek emergency medical attention if you experience symptoms of a spinal blood clot: 

  • Back pain 
  • Numbness or muscle weakness in the lower body 
  • Loss of bladder or bowel control 

Allergic Reactions 

Although rare, a severe allergic reaction to Savaysa may occur. Seek immediate medical assistance if you encounter any signs of an allergic response, such as: 

  • Hives 
  • Difficulty breathing 
  • Swelling of the face, lips, tongue, or throat 

Not all side effects of Savaysa are included in this list. Inform your doctor if any unlisted effects occur. 


Before starting treatment with Savaysa, inform your doctor if you have any known allergies, particularly to edoxaban or other medications. 

Consult your pharmacist for more information about Savaysa, as it may contain inactive ingredients that may prompt allergic reactions or other complications. 

To ensure Savaysa is safe for you, disclose to your physician your medical background, especially if you have a history of: 

  • Liver disease 
  • Kidney disease 
  • Bleeding problems (e.g., gastrointestinal or intracranial bleeding) 
  • Blood disorders (e.g., anemia, hemophilia, thrombocytopenia) 
  • Recent major injury or surgery 
  • Frequent falls or injuries 
  • Stroke 
  • Antiphospholipid syndrome (a clotting disorder) 

Notify all your healthcare providers of any current or recently started or stopped medications, including prescription/nonprescription drugs, vitamins, and herbal supplements, to mitigate the risk of drug interaction with Savaysa. 

Some of the products that may interact with Savaysa include: 

  • Mifepristone 
  • Drugs that may cause bleeding or bruising: 
    • Antiplatelet drugs (e.g., clopidogrel) 
    • NSAIDs (e.g., ibuprofen, naproxen) 
    • Blood thinners (e.g., warfarin, enoxaparin) 
  • Certain antidepressants: 
    • SSRIs (e.g., fluoxetine) 
    • SNRIs (e.g., desvenlafaxine, venlafaxine) 

The efficacy of Savaysa may be influenced by other medications that impact its elimination from the body. Rifampin, among other drugs, is an example of such an interaction. 

Concurrent use of Savaysa and aspirin may heighten the likelihood of bleeding. Nevertheless, if your healthcare provider has advised you to take low-dose aspirin (usually 81-162 milligrams per day) to prevent heart attack or stroke, adhere to this regimen unless otherwise directed by your doctor. 

Before undergoing surgery, dental work, or any medical procedure, inform the doctor or dentist in advance about your use of Savaysa. If anesthesia is required, temporary discontinuation of this medication might be necessary. 

Savaysa has the potential to induce stomach bleeding. Avoid excessive alcohol consumption when using this medicine, as it may elevate the risk of stomach bleeding. Limit alcoholic beverages and seek guidance from your healthcare provider or pharmacist regarding safe levels of alcohol consumption. 

To minimize the risk of heavy bleeding while using Savaysa, exercise caution with sharp objects like razors and nail cutters and avoid contact sports. Opt for an electric razor for shaving and a soft toothbrush for brushing your teeth. If you experience a fall or injury, especially to the head, promptly contact your doctor for evaluation and necessary follow-up. 

Inform your doctor about your pregnancy status or if you become pregnant, as taking Savaysa during pregnancy can lead to bleeding in both the mother and the unborn baby. 

The transfer of edoxaban into breast milk is uncertain. Prior to breastfeeding, consult your doctor for guidance. 

Additional information

Generic name:

Edoxaban Tosilate


Film Coated Tablet, Tablet


30mg, 60mg

Quantities Available:


Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Savaysa (Edoxaban Tosilate). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Savaysa (Edoxaban Tosilate).