Silkis Ointment (Calcitriol) Medication


Silkis Ointment (Calcitriol)

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Drug Description


Silkis ointment is a topical medication used for the treatment of plaque psoriasis (psoriasis vulgaris) with up to 35% of body surface area involvement.  

The ointment contains the active ingredient calcitriol, which is a vitamin D analogue. Silkis ointment helps reduce the production of excessive skin cells that cause psoriasis symptoms. It is available in a 3 micrograms per gram (3mcg/g) concentration. It works by controlling the excessive production of skin cells seen in psoriasis, thereby eliminating the red, scaly patches seen in the skin condition. 

Use and Dosage 

Silkis ointment is typically applied once daily to the affected areas of the skin, usually twice daily, morning and evening. Do not use more than 30 g of this medication daily, and only use the ointment if the affected body area is 35% or less. 

To use Silkis ointment effectively, follow these steps: First, clean and dry the affected area with mild soap and water, ensuring it is free from any dirt or moisture. Gently pat the area dry before proceeding. Next, take a small amount of Silkis ointment and apply it as a thin layer to the affected skin. Massage the ointment gently until it is fully absorbed. Avoid applying the ointment to open wounds or severely damaged skin. Additionally, be careful to avoid any contact with the eyes, mouth, or other mucous membranes. If accidental contact occurs, thoroughly rinse the affected area with water. After applying the ointment, remember to wash your hands thoroughly to remove any residue and prevent accidental contact with sensitive areas.  

The duration of treatment with Silkis ointment may vary from person to person and depends on the severity of the condition being treated. Follow the recommended treatment duration provided by your healthcare professional. In general, Silkis ointment is not recommended for use for more than 6 weeks without medical supervision. 

Use the Ointment exactly as prescribed by your doctor. If you miss a dose, apply it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.  

Side Effects 

Common Side Effects  

  • Abnormal laboratory test results, including urine tests 
  • Flu-like symptoms 
  • High amounts of calcium in urine 
  • Itch 
  • Psoriasis symptoms 
  • Skin discomfort 

Serious Side Effects 

  • Difficulty breathing or swallowing) 
  • Excessive thirst 
  • Excessive urination 
  • Nausea 
  • Rashes or blisters over the body 
  • Skin infection 
  • Swelling of the hands, feet, ankles, face, lips, mouth, or throat 
  • Vomiting 


  • Caution in patients receiving medications known to increase serum calcium levels: Silkis ointment should be used with caution in patients who are receiving medications that are known to increase serum calcium levels. This caution is mentioned to avoid potential complications related to high calcium levels in the blood. 
  • Individual availability of specific brand names: The specific brand name of Silkis ointment may not be available in all locations. 
  • Excipients in the ointment: Silkis ointment contains excipients or inactive ingredients. If you have any known allergies or sensitivities to specific excipients, review the product’s packaging or consult with a healthcare professional for guidance. 
  • Hypercalcemia: Silkis ointment should be used with caution in patients who have conditions or are taking medications that can increase calcium levels in the blood, as it may further elevate serum calcium levels and lead to hypercalcemia (high levels of calcium in the blood). Monitoring of calcium levels may be necessary in these patients. 
  • Renal impairment: Patients with severe renal impairment or end-stage renal disease may be at an increased risk of developing hypercalcemia when using Silkis ointment. Close monitoring of calcium levels is important in these patients to prevent complications. 
  • Photosensitivity: Silkis ointment may cause increased sensitivity to sunlight or ultraviolet (UV) light. Avoid excessive sun exposure and the use of tanning beds or sunlamps during treatment. If exposure to sunlight or UV light cannot be avoided, appropriate sun protection measures should be taken. 
  • Eye contact: Silkis ointment should be kept away from the eyes and mucous membranes. In case of accidental contact, rinse thoroughly with water. 
  • Use on open wounds or damaged skin: Silkis ointment should not be applied to open wounds or severely damaged skin, as it may cause irritation or other adverse reactions.  
  • Pediatric use: The safety and efficacy of Silkis ointment in pediatric patients under 18 years of age have not been established. It should be used with caution in this population and under the guidance of a healthcare professional.  

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Silkis Ointment (Calcitriol). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Silkis Ointment (Calcitriol).