Synjardy XR (Empagliflozin/Metfromin hcl) Medication


Synjardy XR (Empagliflozin/Metfromin hcl)

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Drug Description


Synjardy XR is a prescribed medication used in conjunction with diet and exercise to enhance blood sugar management in adult patients diagnosed with type 2 diabetes mellitus. 

Synjardy XR may also be prescribed to reduce the likelihood of mortality due to heart attack, stroke, or heart failure in adult patients diagnosed with type 2 diabetes and concurrent heart disease. 

Comprising two active components, empagliflozin, an SGLT2 inhibitor, and metformin hydrochloride, a biguanide, Synjardy XR works by restoring the body’s insulin response, increasing sugar removal by the kidneys, reducing liver sugar production, and decreasing sugar absorption in the stomach and intestines. 

Uses and Dosage 

Before taking Synjardy XR and with every prescription refill, carefully review its medication guide and patient information leaflet. Consult your healthcare provider or pharmacist if you have any queries or concerns. 

The appropriate dosage of Synjardy XR is determined by the patient’s medical condition, response to treatment, and concurrent medications. 

To mitigate potential side effects (e.g., diarrhea, nausea), your doctor might recommend starting this medication with a low dose and progressively elevating it. Adhere closely to your doctor’s guidance. 

Typically, Synjardy XR is taken once daily in the morning with a meal, as prescribed by the doctor.  

Synjardy XR tablets must be swallowed whole, not crushed, dissolved, or chewed. Breaking them apart can cause the entire dosage to be released at once, increasing the likelihood of experiencing adverse reactions. 

Unless instructed otherwise by your doctor, adequate fluid intake must be maintained during medication usage. 

For optimal results, take this medication regularly at around the same time each day.  

Inform your doctor if your condition fails to improve or deteriorates (whether your blood sugar levels are excessively high or low). 

Side Effects 

Listed below are the potential adverse effects of Synjardy XR. Tell your doctor promptly if any of them persist or worsen. 

Common Side Effects 

  • Low blood sugar 
  • Indigestion, stomach pain, gas, nausea, vomiting, diarrhea 
  • Bladder infection 
  • Vaginal yeast infection (manifesting as vaginal itching or discharge) 
  • Headache, weakness 
  • Runny or stuffy nose, sore throat 

Serious Side Effects 

  • A sensation of faintness, potential fainting 
  • Signs of dehydration: 
    • Vertigo 
    • Cognitive disorientation 
    • Heightened thirst 
    • Reduced urination 
  • Ketoacidosis (excessive blood acid): 
    • Nausea 
    • Vomiting 
    • Abdominal discomfort 
    • Cognitive confusion 
    • Unusual drowsiness 
    • Respiratory distress 
  • Lactic acidosis: 
    • Unusual muscular pain 
    • Respiratory difficulty 
    • Abdominal discomfort 
    • Vomiting 
    • Irregular heart rate 
    • Vertigo 
    • Cold sensation 
    • Profound weakness or fatigue 
  • Indications of a bladder infection: 
    • Pain or burning during urination 
    • Hematuria 
    • Pelvic or back pain 

Stop taking Synjrady XR and call your doctor immediately if any serious side effects are experienced. 

Seek medical attention right away if you have signs of a serious genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or not feeling well. These symptoms may get worse quickly. 

Allergic Reactions 

Although rare, a severe allergic reaction to Synjardy XR may occur. Seek immediate medical attention in case of any signs of an allergic reaction, such as: 

  • Hives 
  • Swelling of the face, lips, tongue, or throat 
  • Difficulty breathing 
  • Trouble swallowing 

Not all side effects of Synjardy XR are included in this list. Tell your doctor if any unlisted effects occur. 


Before starting treatment with Synjardy XR, inform your doctor if you have any known allergies, particularly to empagliflozin, metformin hydrochloride, or other medicines. 

Consult your pharmacist for more details about Synjardy XR, as it may contain inactive ingredients that may cause allergic reactions or other complications. 

To ensure Synjardy XR is safe for you, disclose to your physician your medical background, especially if you have a history of: 

  • Respiratory issues (e.g., asthma, obstructive lung disease) 
  • Hematological disorders (e.g., anemia, vitamin B12 deficiency) 
  • Dehydration 
  • Cardiovascular conditions (e.g., heart failure, recent heart attack) 
  • Renal impairment 
  • Hepatic dysfunction 
  • Alcohol usage/abuse 
  • Genital yeast infections (vaginal or penile) 

Numerous medications can influence blood sugar levels, potentially complicating regulation. Before initiating, discontinuing, or altering any medication, consult your doctor or pharmacist regarding its impact on blood sugar. 

Monitor your blood sugar as advised by your physician, sharing both readings and any signs of hyperglycemia or hypoglycemia. Adjustments to your diabetes regimen, physical activity plan, or dietary intake may be necessary and should be discussed with your doctor. 

Ensure that all laboratory personnel and medical professionals are aware of your usage of Synjardy XR, as it may result in a positive glucose test in your urine. 

Before undergoing surgery or any procedure involving the administration of a dye through intravenous injection for X-rays or CT scans, it may be necessary to temporarily discontinue the use of Synjardy XR.  

Adhere to your doctor’s guidance regarding the usage of Synjardy XR if you are pregnant or become pregnant, as diabetes management is crucial during pregnancy. This medication should not be taken in the second or third trimester of pregnancy. 

Metformin may alter the menstrual cycle, promoting ovulation and elevating the chance of conception. Seek guidance from a healthcare professional or pharmacist regarding the implementation of effective contraception during Synjardy XR treatment. 

Small amounts of metformin can be transferred to breast milk, whereas the transfer of empagliflozin to breast milk is not yet determined. Consult with your doctor before engaging in breastfeeding. 

Additional information

Generic name:

Empagliflozin/Metfromin hcl


ER Tablet


12.5/1000mg, 25/1000mg

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Synjardy XR (Empagliflozin/Metfromin hcl). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Synjardy XR (Empagliflozin/Metfromin hcl).