Tenoretic (Atenolol/chlorthalidone) Medication


Tenoretic (Atenolol/chlorthalidone)

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Table of contents:

Drug Description


Tenoretic is a prescribed medication indicated for the treatment of hypertension (high blood pressure). Lowering blood pressure mitigates the occurrence of life-threatening cardiovascular incidents, particularly strokes and heart attacks. 

Tenoretic comprises two medications: atenolol and chlorthalidone.  

Atenolol, a beta blocker, works by obstructing the impact of specific natural compounds like epinephrine on the heart and blood vessels, resulting in lowered heart rate, reduced blood pressure, and diminished cardiac strain.  

On the other hand, chlorthalidone, a diuretic, works by prompting the elimination of excess salt and water from the body, potentially resulting in increased urine production upon initial use. Moreover, it facilitates blood vessel relaxation, thereby promoting smoother blood circulation. 

Uses and Dosage 

Before taking Tenoretic and with every prescription refill, carefully read its medication guide and patient information leaflet. If you have any questions, consult your doctor or pharmacist for guidance. 

Tenoretic dosage is determined based on the patient’s medical condition and response to the treatment. 

Typically, Tenoretic is taken once daily as prescribed by the doctor, without regard to food intake. 

It will be best to take this medication at least four hours before going to bed, as taking it too close to bedtime may necessitate waking up to urinate. 

To achieve the best outcome, take Tenoretic exactly as directed at around the same time each day. Seek medical advice before making any changes to the recommended dosage, frequency, or duration of use. 

Keep taking this medication even if you are feeling well, as many individuals with high blood pressure do not experience symptoms. 

Inform your doctor of any lack of improvement or deterioration in your condition, such as persistently elevated or rising blood pressure readings. 

Side Effects 

Listed below are the potential adverse effects of Tenoretic. Promptly inform your doctor if any of them persist or worsen. 

Common Side Effects 

  • Dizziness, fatigue, or weakness 
  • Nausea or vomiting 
  • Loss of appetite 
  • Constipation 
  • Stomach cramps 

Serious Side Effects 

  • Indications of fluid and electrolyte issues: 
    • Mood alterations 
    • Confusion 
    • Muscle pain or weakness 
    • Irregular heartbeat 
    • Severe dizziness or fainting 
    • Rapid heartbeat 
    • Increased thirst 
    • Seizures 
    • Profound fatigue or weakness 
    • Appetite loss 
    • Urinary difficulties or alterations 
    • Dry mouth or eyes 
    • Severe stomach upset or vomiting 
  • Symptoms of elevated blood sugar: 
    • Confusion 
    • Drowsiness 
    • Increased thirst 
    • Heightened appetite 
    • Frequent urination 
    • Flushing 
    • Rapid breathing 
    • Fruit-like breath odor 
  • Signs of pancreas issues (pancreatitis): 
    • Intense abdominal or back pain 
    • Severe gastrointestinal distress 
  • Chills and cold sensation 
  • Severe dizziness or fainting 
  • Slow heart rate 
  • Restlessness 
  • Shortness of breath, significant weight gain, or limb swelling 
  • Low mood or depression 
  • Fever, chills, sore throat, unexplained bruising or bleeding, or profound fatigue or weakness 
  • Yellowing of the skin or eyes (jaundice) 
  • Abnormal burning, numbness, or tingling sensations 

Call your doctor right away and ask for medical help if any of the serious side effects listed above are experienced. 

Allergic Reactions 

Although rare, a severe allergic reaction to Tenoretic may occur. Prompt medical assistance must be sought in case of any signs of an allergic reaction, such as: 

  • Hives 
  • Itching 
  • Red, swollen, blistered, or peeling skin with or without fever 
  • Wheezing 
  • Chest or throat tightness 
  • Difficulty breathing, swallowing, or talking 
  • Unusual hoarseness 
  • Swelling of the mouth, face, lips, tongue, or throat 

Not all side effects of Tenoretic are included in this list. Tell your doctor If any unlisted symptoms arise. 


Before starting treatment with Tenoretic, inform your doctor if you have any known allergies, particularly to atenolol or chlorthalidone. 

Consult your pharmacist for further information about Tenoretic, as it may include non-active components that could potentially trigger allergies or other complications.  

To ensure Tenoretic is safe for you, disclose to your physician your medical background, especially if you have a history of: 

  • Liver disease 
  • Kidney disease 
  • Heart rhythm issues (e.g., slow heartbeat, second or third-degree atrioventricular block) 
  • Gout 
  • Lupus 
  • Respiratory conditions (e.g., asthma, chronic bronchitis, emphysema) 
  • Circulatory problems (e.g., Raynaud’s disease, peripheral vascular disease) 
  • Untreated mineral imbalances (e.g., low potassium) 
  • Severe allergic reactions requiring epinephrine 
  • Muscle/nerve ailment (myasthenia gravis) 

Some products may interact with Tenoretic, including dofetilide, fingolimod, and lithium. To lower the risk of such interactions, inform all healthcare providers of any current or recently started or stopped medications, including prescription and over-the-counter drugs, vitamins, and herbal supplements. 

Certain products may contain components that could elevate heart rate or blood pressure. Inform your pharmacist about all products you are using and inquire about safe usage, especially with cough-and-cold products, dietary supplements, or NSAIDs like ibuprofen/naproxen. 

Apple juice and orange juice can impede your body’s complete absorption of atenolol. Refrain from consuming these juices within a 4-hour window of taking Tenoretic unless directed otherwise by your doctor or pharmacist. 

If you are also prescribed cholesterol-lowering medications like bile acid-binding resins such as cholestyramine or colestipol, ensure to take Tenoretic either at least 2 hours before or at least 4 hours after these medications. 

Tenoretic can lower your blood potassium levels. Consult your doctor regarding potassium supplementation in your diet, which may include a prescribed potassium supplement. 

Tenoretic can hinder the detection of symptoms indicating an overactive thyroid, such as rapid heartbeat. Abruptly discontinuing Tenoretic in the case of an overactive thyroid can exacerbate the condition and potentially pose a life-threatening risk. Consult your doctor for further guidance. 

The use of Tenoretic may result in inaccurate test results for certain lab tests (such as parathyroid, protein-bound iodide). To ensure accurate interpretation, notify laboratory personnel and all medical professionals about your current medication regimen. 

Tenoretic can heighten sun sensitivity. Restrict sun exposure, avoid tanning facilities, and use sunscreen with protective clothing when outdoors. Notify your doctor promptly if you experience sunburn or skin blistering/redness. 

Refrain from engaging in activities that require alertness, such as driving or multitasking, until you have assessed the impact of Tenoretic on your system. 

Inform your doctor of excessive sweating, fluid depletion, vomiting, or diarrhea while taking Tenoretic, as it may result in hypotension (low blood pressure). 

Tenoretic poses a risk to the developing fetus if taken during pregnancy. Promptly contact your healthcare provider if you are pregnant or become pregnant while taking this medication. 

Inform your doctor if you are currently breastfeeding and discuss the potential risks of Tenoretic to your infant. 

Additional information

Generic name:

Atenolol/Chlorthalidone, Atenolol/chlorthalidone


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50/12.5mg, 50/25mg, 100/25mg

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Tenoretic (Atenolol/chlorthalidone). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Tenoretic (Atenolol/chlorthalidone).