Indications 

Chlorpromazine is a conventional antipsychotic medication primarily utilized to manage psychiatric conditions like schizophrenia, but it has a range of other indications. These include the treatment of bipolar I acute manic episodes, acute agitation characterized by explosive hyperexcitable behavior disproportionate to the initial provocation, persistent singultus, relief of apprehension before surgery, adjunct treatment of tetanus, acute intermittent porphyria, and off-label treatment of serotonin syndrome and migraine-associated relief of nausea and vomiting.  

Chlorpromazine’s effectiveness in treating bipolar disorder has been mainly established for controlling manic episodes, which include symptoms such as excessive energy, decreased need for sleep, increased excitability and impulsivity, and grandiose ideations. 

Uses and Dosage 

Chlorpromazine is a medication indicated for treating specific mental and mood disorders, such as schizophrenia, psychotic disorders, manic phases of bipolar disorder, and severe behavioral problems in children. This medication improves cognitive function, reduces anxiety and nervousness, and enhances participation in daily activities. it can decrease aggressive behavior and the impulse to harm oneself or others. 

You should take Chlorpromazine orally, with or without food, by the instructions provided by your doctor, usually 2-4 times a day. Your doctor will determine the dosage based on your medical condition, age, and response to treatment. In children, the dosage will depend on their weight. To minimize the risk of side effects, your doctor may initially prescribe a low dose and increase it gradually. Be sure to follow your doctor’s instructions carefully. 

Side Effects 

Chlorpromazine may cause certain side effects, such as:  

• Drowsiness 
• Dizziness 
• Lightheadedness 
• Dry mouth 
• Blurred vision 
• Tiredness 
• Nausea 
• Constipation 
• Weight gain 
• Trouble sleeping 

If any of these side effects persist or worsen, inform your doctor or pharmacist promptly. 

Note that dizziness and lightheadedness may increase the risk of falling, especially when getting up from a sitting or lying position; get up slowly to prevent accidents. 

In rare cases, Chlorpromazine may cause muscle or nervous system problems known as extrapyramidal symptoms (EPS). Your doctor may prescribe another medication to alleviate these side effects in such instances. If you experience feelings of anxiety, agitation, jitteriness, drooling, trouble swallowing, restlessness, constant need to move, tremors, shuffling walk, severe muscle spasms or cramping, such as twisting of the neck, arching of the back, or rolling of the eyes, or a mask-like expression on the face, notify your doctor immediately. 

Remember that your doctor has prescribed this medication because the benefits outweigh the risk of side effects. Many individuals using Chlorpromazine do not experience severe side effects. 

Caution 

Before taking chlorpromazine, inform your doctor or pharmacist if you have any allergies to other phenothiazine drugs like thioridazine or perphenazine or any other allergies. This medication may contain inactive ingredients that trigger allergic reactions or other complications. Consult your pharmacist for more details. 

Before using this medication, inform your doctor or pharmacist of your medical history, especially if you have or have had liver problems, kidney problems, heart problems such as angina, heart attack, fast/irregular heartbeat, low blood pressure, glaucoma, seizures, an enlarged prostate, breathing issues such as severe asthma, emphysema, or lung infections, blood or clotting blood problems such as low white blood cell count, low platelets, anemia, or hemophilia, pheochromocytoma, drug/alcohol/substance use disorder, or Parkinson’s disease. Providing your complete medical history will help your doctor make an informed decision regarding your treatment plan.