Indications 

Vraylar (cariprazine) is an antipsychotic medication that is clinically utilized for the treatment of mental health and mood disorders, including schizophrenia, certain types of bipolar I disorder, and as an adjunctive therapy for major depressive disorder (MDD).  

Administered in the form of a once-daily capsule, Vraylar is known to regulate neurotransmitters in the brain, such as dopamine and serotonin, although the exact mechanism of action remains unknown.  

Vraylar’s therapeutic effect is due to its partial agonist activity at central dopamine D₂ and serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors.  

Vraylar is indicated for use in adults with schizophrenia, acute manic or mixed episodes associated with bipolar I disorder, depressive episodes associated with bipolar I disorder (bipolar depression), and as an adjunctive therapy to an antidepressant for major depressive disorder (MDD). 

Uses and Dosage 

Read the Medication Guide provided by your pharmacist prior to initiating cariprazine therapy, and upon receiving a refill. In case you have any queries, do not hesitate to consult your physician or pharmacist. 

This medication is taken orally, with or without food, once daily, as prescribed by your doctor. The dosage will depend on several factors such as your medical condition, response to treatment, and concurrent medication use.  

Inform your doctor and pharmacist about all products, including prescription drugs, over-the-counter drugs, and herbal remedies, that you are currently using. 

To minimize the risk of adverse effects, your physician may recommend starting with a low dose and gradually increasing it. Adhere strictly to your doctor’s instructions. 

For optimal therapeutic benefit, take this medication regularly at the same time each day. If you find it difficult to remember, you may consider setting an alarm to remind you. 

Do not alter the dosage, frequency or duration of use beyond the prescribed regimen. Doing so will not hasten your recovery, but will increase your risk of side effects. If your condition does not improve or deteriorates, inform your doctor promptly. 

Side Effects 

Signs of an allergic reaction to Vraylar may include hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. If you experience these symptoms, seek emergency medical attention immediately. 

Contact your healthcare provider immediately if you experience any of the following side effects while taking Vraylar: 

• Sudden weakness or numbness, particularly on one side of your body 
• Difficulty speaking or vision problems 
• A light-headed sensation, or feeling as though you may pass out 
• Severe agitation or distress 
• Seizures 
• Involuntary muscle movements, such as chewing, lip smacking, frowning, tongue movement, blinking or eye movement 
• Trouble swallowing, or accidentally inhaling food or drink 
• Low white blood cell counts, which can cause fever, chills, sore throat, mouth sores, skin sores, sore throat, cough, trouble breathing, or feeling light-headed 
• High blood sugar, characterized by increased thirst, increased urination, dry mouth, or fruity breath odor 
• Severe nervous system reaction, indicated by very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, or feeling as though you may pass out 

Vraylar may have long-lasting effects on your body, and some side effects may persist for several weeks after you stop taking the medication. You may experience new side effects whenever your dosage is adjusted. 

Common side effects of Vraylar include involuntary muscle movements, upset stomach, vomiting, drowsiness, and restlessness. 

Cautions 

Prior to taking cariprazine, inform your physician or pharmacist about any known allergies to the medication or other allergens. This product may contain inactive elements that can elicit allergic reactions or other adverse effects.  

Before using this medication, make sure to notify your doctor or pharmacist about your medical history, especially if you have a history of cerebrovascular disease, stroke, diabetes, heart failure, arrhythmias, dehydration, hypertension, nervous system disorders (such as dementia, neuroleptic malignant syndrome, seizures), obesity, low white blood cell count (caused by medications), or swallowing difficulties. 

Using cariprazine can lead to reduced sweating, increasing the risk of heat stroke. Avoid activities that can cause overheating, such as strenuous exercise or work in hot weather, and the use of hot tubs. During hot weather, ensure that you drink enough fluids and dress lightly. If you experience overheating, quickly look for a place to cool down and rest. Seek medical assistance immediately if you have a persistent fever, headache, dizziness, or mental/mood changes. 

Older individuals may be more susceptible to the adverse effects of cariprazine, especially seizures, drowsiness, dizziness, confusion, tardive dyskinesia, swallowing difficulties, and other serious (but rare) side effects. See the Warning section for more information. Drowsiness, dizziness, lightheadedness, and confusion may increase the risk of falling. 

Before undergoing surgery or dental procedures, inform your physician or dentist of all the products you use, including prescription drugs, non-prescription drugs, and herbal products.