Zofran Oral Solution (Ondansetron) Medication

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Zofran Oral Solution is an oral medication primarily used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It contains the active ingredient ondansetron, which works by blocking the action of serotonin, a natural substance in the body that can cause nausea and vomiting.  

Serotonin is released in the gut and can trigger a vomiting reflex through the 5-HT3 receptors. Ondansetron works by binding to and blocking these receptors, preventing the serotonin from binding, and thereby inhibiting the vomiting reflex. By blocking the action of serotonin, Zofran Oral Solution helps to reduce or prevent nausea and vomiting. 

Use and Dosage 

Zofran Oral Solution is usually taken by mouth with or without food. Measure the liquid medicine with the dosing syringe provided, or with a special measuring spoon or cup. If you are taking it on a prescribed schedule, take it regularly to get the most benefit from it. To help you remember, take it at the same time each day. 

The recommended dosage and usage instructions for Zofran Oral Solution may vary depending on the specific condition being treated. Follow the instructions provided by your healthcare professional or the label on the medication. Here are some general guidelines: 

  • Adults: The initial dosage for adults is typically 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. After the initial dose, the recommended maintenance dose is 8 mg every 8 hours.  
  • Children: The use and dosage of Zofran Oral Solution in children must be determined by a healthcare professional. The appropriate dosage for children will depend on their weight and the specific condition being treated. 

However, its usage may extend to other conditions as determined by a healthcare professional. 

Side Effects 

Common Side Effects

  • Chills 
  • Constipation 
  • Drowsiness 
  • Headache 
  • Tiredness 
  • Weakness 

Serious Side Effects 

  • Agitation 
  • Blurred vision or vision loss 
  • Chest pain 
  • Coma (loss of consciousness) 
  • Confusion 
  • Difficulty breathing or swallowing 
  • Dizziness, light-headedness, or fainting 
  • Excessive sweating 
  • Fast, slow, or irregular heartbeat 
  • Fever 
  • Hallucinations (seeing things or hearing voices that do not exist) 
  • Hives 
  • Hoarseness 
  • Itching 
  • Loss of coordination 
  • Nausea, vomiting, or diarrhea 
  • Rash 
  • Seizures 
  • Shortness of breath 
  • Stiff or twitching muscles 
  • Swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs 


  • Allergic reactions: Individuals with a known hypersensitivity or allergy to ondansetron or any of the ingredients in the Solution should not take the medication. Allergic reactions may include rash, itching, swelling, severe dizziness, or difficulty breathing. Immediate medical attention should be sought if an allergic reaction occurs. 
  • Electrolyte imbalance: Ondansetron may cause changes in electrolyte levels, particularly potassium and magnesium. This is more likely to occur with prolonged use or in individuals with underlying medical conditions. Close monitoring of electrolyte levels may be necessary, especially in patients at risk of electrolyte imbalances. 
  • Liver function: Zofran Oral Solution is primarily metabolized by the liver, and caution should be exercised in individuals with liver impairment. Dose adjustments may be necessary in these cases. 
  • Heart rhythm disturbances: Ondansetron may prolong the QT interval, which can lead to a potentially serious heart rhythm disturbance called torsades de pointes. This risk may be increased in individuals with certain medical conditions, such as a history of heart rhythm disorders or electrolyte imbalances, or those taking other medications that can prolong the QT interval.  
  • Pregnancy and breastfeeding: The use of Zofran Oral Solution during pregnancy and breastfeeding should be discussed with a healthcare professional. While studies have not shown an increased risk of birth defects, the safety of ondansetron during pregnancy is still being studied.  
  • Serotonin syndrome: Ondansetron may increase the risk of serotonin syndrome, a potentially life-threatening condition that can occur when there is an excess of serotonin in the body. Serotonin syndrome symptoms may include agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and coordination difficulties.  
  • Gastrointestinal obstruction: Zofran Oral Solution is not recommended for use in patients with known or suspected gastrointestinal obstruction. Ondansetron may mask symptoms of this condition, leading to a delay in diagnosis and appropriate treatment. 
  • Children and elderly: Ondansetron can be used in children and the elderly, but caution should be exercised, and appropriate dosage adjustments may be necessary.  
  • Drug interactions: the Solution may interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects.  
  • Driving and operating machinery: the Solution may cause dizziness or drowsiness in some individuals. If these side effects occur, avoid driving or operating machinery until you know how the medication affects you.  

Additional information

Generic name:



Oral solution



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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Zofran Oral Solution (Ondansetron). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Zofran Oral Solution (Ondansetron).