Zyclara Cream Pump (Imiquimod) Medication


Zyclara Cream Pump (Imiquimod)

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Drug Description


Zyclara Cream Pump is a prescription topical cream used to treat various skin conditions, including actinic keratosis (precancerous skin lesions), basal cell carcinoma (a type of skin cancer), and genital warts caused by the human papillomavirus (HPV). 

Zyclara Cream Pump contains the active ingredient imiquimod, which is classified as a topical immunomodulatory. Imiquimod works by stimulating the body’s immune response in the affected area. It activates certain immune cells, such as macrophages and dendritic cells, leading to the release of various immune factors and chemicals, including interferons and cytokines 

Use and Dosage 

Zyclara Cream Pump is typically applied once daily at bedtime. The treatment duration may vary depending on the condition being treated and the instructions provided by your healthcare provider. Follow the prescribed treatment duration and use the cream as directed. 

To use Zyclara Cream Pump (imiquimod), follow these general instructions: 

  1. Wash the area with mild soap and water and pat it dry before applying the cream. 
  2. Before the first use, prime the pump by repeatedly depressing the actuator until the cream is dispensed. This helps ensure that the pump is ready for use. 
  3. Dispense a small amount of cream onto a clean fingertip and apply a thin layer to the affected area of the skin. Gently rub the cream into the skin until it disappears. 
  4. After applying the cream, wash your hands thoroughly to remove any residue. 

Avoid getting the cream in your eyes, nose, mouth, or other mucous membranes. If accidental contact occurs, rinse with water immediately. In addition, avoid sexual contact while the cream is on the skin when Zyclara Cream Pump is being used to treat genital warts. 

Side Effects 

Common Side Effects  

  • Back pain  
  • Chest pain  
  • Cold sores  
  • Cold symptoms (stuffy nose sneezing sore throat) 
  • Diarrhea  
  • Dizziness  
  • Fever blisters  
  • Headache  
  • Loss of appetite  
  • Nausea  
  • Tiredness  
  • Treatment area skin reactions (irritation pain itching dryness flaking scabbing crusting redness hardening of skin changes in color of treated skin)  
  • Vaginal itching or discharge 

Serious Side Effects 

  • Flu-like symptoms 
  • Local Skin Reactions 
  • Sudden vision loss 
  • Blurred vision 
  • Tunnel vision 
  • Eye pain or swelling 
  • Seeing halos around lights 
  • Fast, irregular, or pounding heartbeats 
  • Fluttering in your chest 
  • Shortness of breath 
  • Sudden dizziness 
  • Lightheartedness 
  • Faint 
  • Headache 
  • Confusion 
  • Slurred speech 
  • Arm or leg weakness 
  • Trouble walking 
  • Loss of coordination 
  • Feeling unsteady 
  • Very stiff muscles 
  • High fever 
  • Profuse sweating, 
  • Tremors 
  • Skin drainage (weeping) 
  • Breakdown of the outer layer of your skin (erosion) 


  • Skin irritation: Zyclara Cream Pump may cause skin irritation, including redness, itching, burning, or swelling at the application site. If severe or persistent irritation occurs, contact your healthcare provider 
  • Avoid contact with eyes, lips, and mucous membranes: Zyclara Cream Pump should be applied only to the affected area and should not come into contact with the eyes, lips, or mucous membranes. If accidental contact occurs, rinse thoroughly with water. 
  • Sun exposure: Avoid exposing the treated area to sunlight or artificial UV rays, such as tanning beds or sunlamps, as Zyclara Cream Pump can make your skin more sensitive to sunlight. Use sunscreen and protective clothing when outdoors. 
  • Pregnancy and breastfeeding: Discuss with your healthcare provider the potential risks and benefits of using Zyclara Cream Pump during pregnancy or while breastfeeding, as the safety of the medication in these situations is not well-established 
  • Interaction with other medications: Inform your healthcare provider about any other medications, including over-the-counter products that you are using, as they may interact with Zyclara Cream Pump 
  • Skin conditions: Zyclara Cream Pump may not be suitable for all skin conditions. Inform your healthcare provider about any existing skin conditions or allergies you may have before using the medication 
  • Allergic reactions: Some individuals may experience allergic reactions to Zyclara Cream Pump. If you develop symptoms such as rash, hives, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat, seek immediate medical attention. 
  • Open wounds or broken skin: Zyclara Cream Pump should not be applied to open wounds, broken skin, or areas with cuts or abrasions. It is intended for use on intact skin only 
  • Immune system disorders: If you have a weakened immune system due to conditions such as HIV/AIDS or are taking immunosuppressive medications, discuss the use of Zyclara Cream Pump with your healthcare provider, as it may not be suitable or may require additional monitoring. 
  • Interference with other topical products: Avoid using other topical products, such as cosmetics or other medications, on the same area where Zyclara Cream Pump has been applied, unless specifically instructed by your healthcare provider. 
  • Children: The safety and effectiveness of Zyclara Cream Pump in children under the age of 18 have not been established. Use in this age group should be done under the guidance of a healthcare provider.  

Additional information

Generic name:



Pump bottle



Quantities Available:

7.5 grams, 30 grams

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Zyclara Cream Pump (Imiquimod). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Zyclara Cream Pump (Imiquimod).