Indications 

Arnuity Ellipta is a prescription medication indicated for the maintenance treatment of asthma in adults and children 5 years old and above. 

As an inhaled corticosteroid, Arnuity Ellipta control and prevent asthma symptoms (such as wheezing and shortness of breath) by reducing airway inflammation and irritation allowing for easier breathing.   

Arnuity Ellipta needs regular use to be effective and should not be used to alleviate sudden asthma attacks. In case of an asthma attack, promptly use your prescribed quick-relief inhaler. 

Uses and Dosage 

Before using Arnuity Ellipta and with each prescription refill, carefully read its medication guide and patient information leaflet. For questions or clarifications, do not hesitate to ask your physician or pharmacist. 

The dosage of Arnuity Ellipta is determined based on the patient’s medical condition and response to the treatment. Typically, it is inhaled once a day as prescribed by the doctor. 

Doctors usually initiate this medication with an average dose and may adjust it by increasing or decreasing it based on symptom control after a minimum of 2 weeks. 

Arnuity Ellipta contains fluticasone powder preloaded in an inhaler device with measured doses in blister packs. A dose is prepared for inhalation every time the inhaler’s cover is opened completely. 

Opening and closing the inhaler’s cover without inhaling the medicine results in the loss of the dose, which remains in the inhaler but cannot be inhaled. Only open the inhaler cover when ready to use it and avoid wasting doses by not closing the cover until after inhaling the medicine. 

To properly use Arnuity Ellipta, follow these steps: 

1. Open the inhaler cover 
   1. Open the inhaler cover by sliding it down to expose the mouthpiece, which should produce an audible click and decrease the counter by 1. 
   2. This type of inhaler does not require shaking before use. 
   3. If the counter does not decrease after hearing the click, the inhaler will not dispense the medicine. Contact your healthcare provider or pharmacist for assistance. 
2. Exhale 
   1. Exhale fully while holding the inhaler away from your mouth, avoiding exhaling into the mouthpiece. 
3. Inhale the medication 
   1. Place the mouthpiece between your lips, ensuring a snug fit around the curved shape. 
   2. Inhale slowly and deeply through your mouth, not your nose. 
   3. Ensure that you do not obstruct the air vent with your fingers. 
   4. Remove the inhaler from your mouth and hold your breath for 3-4 seconds or as long as comfortable. 
   5. Exhale slowly and gently 
   6. Even if used correctly, the medicine may not be tasted or felt, so avoid taking another dose from the inhaler even if there is no sensation or taste. 
4. Close the inhaler  
   1. Close the inhaler by sliding the cover up and over the mouthpiece as far as it will go. 
   2. You may optionally clean the mouthpiece with a dry tissue if needed, although routine cleaning is unnecessary. 
5. Rinse your mouth. 
   1. After using the inhaler, rinse your mouth with water, spit it out, and avoid swallowing the water. 

Use Arnuity Ellipta regularly at evenly spaced intervals, ideally at the same time daily. Avoid altering your dosage or frequency of use without consulting your doctor. 

To avoid worsening of symptoms, do not discontinue the use of Arnuity Ellipta without consulting your healthcare provider. 

Side Effects 

Listed below are the side effects associated with the use of Arnuity Ellipta. If any of these side effects last or worsen, notify your doctor right away. 

Common Side Effects 

• Stuffy nose, sneezing, sore throat, sinus pain 
• Low fever, cough, wheezing, chest tightness 
• Hoarseness or deepened voice 
• White patches or sores inside the mouth or on the lips 
• Headache 
• Nausea, vomiting, upset stomach 

Serious Side Effects 

• Weakness, tired feeling, nausea, vomiting, feeling like you might pass out 
• Wheezing, choking, or other breathing problems after using this inhaler 
• Blurred vision, tunnel vision, eye pain, or seeing halos around lights 
• Worsening of asthma symptoms 
• Signs of blood vessel inflammation: 
  • Fever 
  • Cough 
  • Stomach pain 
  • Weight loss 
  • Skin rash 
  • Severe tingling 
  • Numbness 
  • Chest pain 
• Signs of liver problems: 
  • Upper stomach pain 
  • Loss of appetite 
  • Dark urine 
  • Clay-colored stools 
  • Jaundice (yellowing of the skin or eyes) 
• Slow growth in children and adolescents 

Inform your doctor immediately if you experience any of the serious symptoms listed above. 

Allergic Reactions 

Rare but severe allergic reactions may occur while using Arnuity Ellipta. Seek immediate medical attention if you experience any of the following symptoms: 

• Rash 
• Severe dizziness 
• Facial, tongue, or throat swelling 
• Breathing difficulties 

This list does not contain all the potential side effects of Arnuity Ellipta. If you experience other effects not listed above, inform your doctor promptly.  

Cautions 

Before using Arnuity Ellipta, inform your doctor and pharmacist if you have any known allergies, especially to: 

• Fluticasone 
• Milk proteins 
• Any ingredients present in Arnuity Ellipta  
• Other medicines 

To ensure Arnuity Ellipta is safe for you, disclose to your physician your medical background, specifically regarding any history of: 

• Current/past infections such as tuberculosis or herpes 
• Osteoporosis (bone loss) 
• Eye problems such as cataracts or glaucoma 
• Liver disease 

Arnuity Ellipta may interact with other medications, potentially affecting its efficacy or increasing the likelihood of severe side effects. To avoid such drug interactions, disclose all your current medications, including prescriptions, over-the-counter drugs, dietary supplements, and herbal products, to your physician and pharmacist. 

Fluticasone removal from the body can be impacted by other medications, altering the efficacy of Arnuity Ellipta. This includes azole antifungals (e.g., ketoconazole), HIV protease inhibitors (e.g., lopinavir), ritonavir, and others. 

Arnuity Ellipta may increase the risk of infections and mask their symptoms. Avoid contact with individuals who may spread contagious infections such as flu, measles, and chickenpox. If exposed to an infection, seek medical advice for further guidance. 

Before using Arnuity Ellipta during pregnancy, a thorough discussion with your physician regarding the potential benefits and risks is advised. Utilize this medication only if it is deemed necessary. 

The transfer of fluticasone through breast milk remains uncertain. Consult your physician before nursing an infant when using this medication.