Indications 

Casodex is a medication classified as an anti-androgen that works by inhibiting the actions of androgens or male hormones in the body.  

This medication is indicated for the treatment of metastatic prostate cancer, which has spread to other parts of the body.  

Casodex is administered in combination with a luteinizing (LOO-tee-in-ize-ing) hormone-releasing hormone or LHRH, which aids in preventing the testicles from producing testosterone. 

Uses and Dosage 

Before taking bicalutamide, read the Patient Information Leaflet available from your pharmacist. In case of any queries, consult your doctor or pharmacist for guidance. 

Take this medication orally as prescribed by your doctor, usually once daily and with or without food. 

To achieve maximum benefits, use this medicine regularly, and take it at the same time every day to avoid missing a dose. 

Do not exceed the prescribed dose or use this medication more frequently or for an extended period than advised. It will not improve your condition any quicker, and it increases the risk of serious side effects. 

As bicalutamide can be absorbed through the skin and lungs, pregnant women or those who may become pregnant should not handle this drug or inhale the dust from its tablets. 

Side Effects 

Allergic Reactions

In case of an allergic reaction, seek emergency medical attention: 

• Hives 
• Difficulty breathing 
• Swelling of your face, lips, tongue, or throat 

Severe Side Effects

Contact your doctor immediately if you experience any of the following: 

• Breast pain or swelling 
• Sudden chest pain, wheezing, dry cough, feeling short of breath 
• Low red blood cells (anemia):
  • Pale skin
  • Unusual tiredness
  • Feeling light-headed or short of breath
  • Cold hands and feet 
• Liver problems:
  • Nausea
  • Upper stomach pain
  • Feeling tired
  • Loss of appetite
  • Dark urine
  • Clay-colored stools
  • Jaundice (yellowing of the skin or eyes)
  • Fever
  • Chills 
• High blood sugar:
  • Increased thirst
  • Increased urination
  • Dry mouth
  • Fruity breath odor 

Common Side Effects  

• Anemia 
• Blood in your urine 
• Fever, chills, or flu-like symptoms 
• Trouble breathing 
• Hot flashes 
• Pain in your back, pelvis, or stomach 
• Swelling in your arms, ankles, legs, or feet 
• Increased night-time urination 
• Weakness or dizziness 
• Nausea, diarrhea, or constipation 

Caution 

Prior to taking bicalutamide, inform your physician or pharmacist about any allergies you may have, including allergies to inactive ingredients that may cause allergic reactions or other complications. Consult with your pharmacist for more information. 

Before using this medication, inform your doctor or pharmacist about your medical history, particularly if you have liver disease, diabetes, or heart disease. 

This medication may cause drowsiness or dizziness. Alcohol or cannabis consumption may exacerbate these effects. Do not drive, operate machinery, or engage in any activities that require vigilance until you can do so safely. Limit your alcohol consumption, and consult your doctor if you use cannabis. 

This medication may increase your skin’s sensitivity to the sun. Avoid excessive sun exposure and tanning beds. When outside, use sunscreen and wear protective clothing. If you experience sunburn or skin blisters/redness, immediately inform your doctor. 

Before undergoing surgery, inform your physician or dentist of all products you use, including prescription drugs, nonprescription drugs, and herbal supplements. 

This medication should not be used by women, particularly during pregnancy or breastfeeding. It may cause harm to the unborn or breastfed infant. Consult your doctor for further information.  

Male patients and their female partners should use effective forms of birth control during and for 130 days after treatment with bicalutamide as this medication may cause sperm damage.