Indications 

Cytotec is a prescription medication used to lower the risk of stomach ulcers during treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, naproxen, and others.  

This medication is usually prescribed to individuals at a heightened risk of experiencing complications from gastric ulceration, such as elderly patients and those with coexisting debilitating conditions.  

Cytotec can also be prescribed to individuals with a high risk of developing gastric ulcers, such as those with a medical history of ulcers. 

As a miscellaneous gastrointestinal agent (GI agent), Cytotec protects the stomach lining by inhibiting stomach acid secretion, lowering the amount of acid that comes in contact with it. 

Uses and Dosage 

Before starting treatment with Cytotec and each subsequent refill, review its patient information leaflet and medication guide. For any questions or clarifications, seek guidance from a healthcare professional. 

The appropriate dosage of Cytotec is contingent upon an individual’s medical condition and response to the treatment. It is typically administered four times per day, following meals and before bedtime, in conjunction with food. 

The duration of Cytotec use is concurrent with the administration of NSAIDs. Do not take more or less than the recommended dose or more frequently than the physician’s directed dose. 

For optimal efficacy, take Cytotec consistently at the same time of day every day. Do not stop intake without consulting a healthcare professional.  

Side Effects 

Listed below are the potential adverse reactions associated with Cytotec. If any of these side effects persist or worsen, notify your physician or pharmacist. 

Common Side Effects 

• Diarrhea 
• Stomach pain 
• Nausea 
• Upset stomach 
• Gas 
• Vaginal bleeding or spotting 
• Heavy menstrual flow 
• Menstrual cramps 

Serious Side Effects  

• Prolonged and severe stomach discomfort or diarrhea 
• Intense thirst or heat sensation 
• Inability to urinate 
• Profuse sweating 
• Hot and dry skin 

Seek immediate medical assistance if you experience any of the severe symptoms listed above. 

Allergic Reactions 

Severe allergic response to Cytotec is rare. However, get immediate medical assistance if you observe any indications of an allergic reaction, such as: 

• Rash 
• Itching 
• Swelling of the face, tongue, or throat 
• Severe dizziness 
• Difficulty breathing  

Note that the list mentioned above of potential side effects of Cytotec is not exhaustive. Contact your physician or pharmacist if you experience any other effects that are not listed. 

Cautions 

Before taking Cytotec, notify your doctor or pharmacist of any known allergies, especially to misoprostol or other prostaglandins. 

Inactive ingredients in this medication may cause allergic reactions or other unfavorable effects. Consult a pharmacist for more details. 

Inform your physician of your medical history, particularly if you have a history of stomach or intestinal conditions, such as inflammatory bowel disease. 

Tell your doctor about all the medicines you are taking, including prescription/nonprescription medicines, vitamins, supplements, and herbal products, to prevent drug interactions. 

Concomitant use of Cytotec and magnesium-containing antacids is contraindicated as it may exacerbate diarrhea caused by the medication. If an antacid is required, consult a healthcare professional or pharmacist to identify an appropriate product. 

The use of Cytotec is strictly contraindicated in pregnant women due to the potential risks of birth defects, premature birth, uterine rupture, miscarriage, incomplete miscarriage, and hazardous uterine bleeding. 

To ensure the absence of pregnancy, it is recommended that women delay taking their initial dose until the second or third day of their menstrual cycle.  

Use of effective birth control is also recommended to prevent pregnancy while taking Cytotec and for a minimum of 1 month following the cessation of therapy. 

Misoprostol can be passed into breast milk; however, there is a lack of published evidence regarding the negative impacts on breastfed infants of mothers consuming Cytotec. Consult your doctor before nursing an infant.