Farxiga (Dapagliflozin) Medication

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Farxiga (Dapagliflozin)

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Description

Drug Description:

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The manufacturer of Farxiga is Astra Zeneca .

Indications:

Farxiga is used:

  • To reduce the risk of further worsening your kidney disease, end-stage kidney disease, death due to cardiovascular disease, and hospitalization for heart failure in adults with chronic kidney disease
  • To reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with heart failure
  • To reduce the risk of hospitalization for heart failure in adult with type 2 diabetes mellitus who also have known cardiovascular disease or multiple cardiovascular risk factors
  • Along with diet and exercise to improve glucose control in adults with type 2 diabetes mellitus

This drug, which is classified as a sodium-glucose cotransporter 2 (SGLT2) inhibitor, blocks some of the sugar and sodium reabsorption in the kidneys and works with the body to flush sugar away in your urine.

Dosage and Administration:

The dose of Farxiga your healthcare provider prescribes will vary depending on the individual and condition being treated. Follow all your healthcare provider’s directions and read packaging labels carefully to ensure the best therapeutic results.

The recommended dosage of Farxiga is based on the estimated glomerular filtration rate (eGFR), a measure of how well your kidneys are working.

eGFR Recommended Dosage
45 or greater 5 mg once daily

Dose can be increased to 10 mg once daily for additional glucose control

25 to less than 45 10 mg once daily
Less than 25 Starting Farxiga is not recommended; however, patients may continue 10 mg once daily to reduce the risk of decline in kidney function, end-stage kidney disease, cardiovascular death, and hypertensive heart failure

 

  • Swallow Farxiga tablets whole and take with or without food at the same time each day.  If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medication at the next regularly scheduled time
  • Do not stop taking Farxiga without first talking to your healthcare provider
  • Do not take more than your prescribed dose or double the dose
  • Continue your prescribed diet and exercise program during treatment
  • Farxiga will cause your urine to test positive for glucose
  • Store at room temperature away from children and pets

Side Effects:

Farxiga may cause some side effects to develop while managing your glucose levels and supporting your heart health. Speak with your healthcare provider for more information regarding any symptoms you may encounter while taking Farxiga.

The most common side effects associated with Farxiga include:

  • Vaginal yeast infections and penile yeast infections
  • Stuffy or runny nose and sore throat
  • Changes in urination (urgent need to urinate more often, in larger amounts, or at night)

Serious Side Effects

Certain serious side effects may occur when taking Farxiga. Stop taking this medication and contact your healthcare provider if you develop any of the following side effects:

  • Ketoacidosis in people with diabetes mellitus (symptoms include nausea, vomiting, stomach pain, tiredness, trouble breathing)
  • Dehydration (loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up
  • Serious urinary tract infections (symptoms include burning when urinating, needing to urinate often, pain in lower stomach, bloody urine)
  • Low blood sugar (hypoglycemia) in people with diabetes mellitus (symptoms include headache, weakness, confusion, shaking, drowsiness, dizziness, irritability, sweating, hunger, fast heartbeat)
  • A rare but serious bacterial infection that causes damage to the tissue under the skin (necrotizing fasciitis) in the area between and around the anus and genitals (symptoms include pain or tenderness, swelling, skin redness)
  • Vaginal yeast infections and yeast infection of the skin around the penis

Allergic Reactions

Do not use Farxiga if you are allergic to dapagliflozin or any of the other listed tablet ingredients. If you develop an allergic reaction, stop using this medication and contact your healthcare provider.

Symptoms of a serious allergic reaction to Farxiga may include:

  • Skin rash
  • Hives (raised red patches on your skin)
  • Swelling of your face, lips, tongue, or throat that may cause difficulty in breathing or swallowing

Warnings and Precautions:

Farxiga should not be taken by anyone with type 1 diabetes.

Farxiga should not be used to improve glucose control in adults with type 2 diabetes who have moderate to severe kidney problems because it may not work.

Farxiga should not be used in people with certain genetic forms of polycystic kidney disease, or who are taking or have recently received immunosuppressive therapy to treat kidney disease.

Do not take Farxiga if you have a history of severe hypersensitivity to the medication, if you have severe renal impairment, and if you are on dialysis.

To ensure your safety when taking Farxiga, tell your healthcare provider if you:

  • Have type 1 diabetes or diabetic ketoacidosis
  • Have liver problems
  • Have a history of urinary tract infections or urinary problems
  • Have a scheduled surgery
  • Have pancreatic problems, including surgery or pancreatitis
  • Drink alcohol often
  • Are pregnant or plan to become pregnant
  • Are breastfeeding

Some drugs have the potential to interact with Farxiga and cause adverse reactions. To avoid this, tell your healthcare provider about all the medications that you take, including over-the-counter medicines, vitamins, and herbal products.

Form and Strengths:

This diabetes and heart medication is available in film coated tablet form.

Farxiga tablet strengths:

  • 5mg
  • 10mg

FAQs:

What is the connection between type 2 diabetes and the risk for chronic kidney disease?

High blood sugar from diabetes can damage the blood vessels in your kidneys, which may cause chronic kidney disease.

Why should people with type 1 diabetes not take Farxiga?

Farxiga should not be taken by people with type 1 diabetes because it may increase the risk of diabetic ketoacidosis (increased ketone in your blood or urine) in those with type 1 diabetes.

Is ketoacidosis a common side effect of Farxiga?

Ketoacidosis has occurred in people who have type 1 or type 2 diabetes during treatment with Farxiga. Ketoacidosis has also occurred in people with diabetes who were sick or who had surgery during treatment with Farxiga. Ketoacidosis is a very serious condition that can happen during treatment with Farxiga even if your blood sugar is less than 250 mg/dL. Should you experience any symptoms of ketoacidosis, such as nausea, vomiting, stomach pain, tiredness, or trouble breathing, stop taking Farxiga and call your healthcare provider right away.

Resources:

  1. https://www.farxiga.com/faq/hero#accordion-612e30f5e9-item-fce4cd8dcf
  2. https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/0be9cb1b-3b33-41c7-bfc2-04c9f718e442/0be9cb1b-3b33-41c7-bfc2-04c9f718e442_viewable_rendition__v.pdf

Additional information

Generic name:

Dapagliflozin

Formulation:

Film Coated Tablet, Tablet

Strength(s):

5mg, 10mg

Quantities Available:

28, 56, 84, 100

Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Farxiga (Dapagliflozin). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Farxiga (Dapagliflozin).