Indications 

Gemtesa is a prescription medication indicated to treat symptoms of overactive bladder (OAB) in adults.  

OAB is characterized by involuntary contractions of the bladder muscles, resulting in frequent urination, a sudden and urgent need to urinate, and the inability to control urination. 

Categorized as a beta-3 adrenergic agonist medication, Gemtesa works by relaxing the bladder muscle to increase its capacity for urine retention. This mechanism of action can potentially alleviate the urgent need to use the bathroom and minimize the incidence of urinary leakage. 

Uses and Dosage 

Before taking Gemtesa and with each refill, carefully review its patient information leaflet and medication guide. Seek guidance from your doctor or pharmacist if you have questions or clarifications. 

The dosage of Gemtesa is based on the individual’s medical condition and response to the treatment.  

Typically, this medication is taken once a day as prescribed by the doctor without regard to food intake. Ingest the tablets by swallowing them whole with a glass of water. 

If the tablet is hard to swallow, crush it and mix it with a tablespoon of applesauce, and promptly take it with a glass of water. Consume everything immediately, and do not save any portion for future use. 

Adhere strictly to the prescribed directions for taking Gemtesa. Refrain from taking more or less of it or more frequently than your physician instructed. 

For optimal benefits, take Gemtesa at the same time(s) daily. Do not stop treatment without the approval of your doctor. 

Side Effects 

Potential side effects associated with the use of Gemtesa are listed below. If any of them last or worsen, notify your physician promptly. 

Common Side Effects 

• Painful urination 
• Nausea and diarrhea 
• Headache 
• Cold symptoms: 
  • Stuffy nose 
  • Sneezing 
  • Sore throat 

Serious Side Effects 

• Inability to fully empty the bladder 
• Pain or burning sensation during urination 

Call your doctor at once if any of the severe symptoms listed above occur. 

Allergic Reactions 

Though rare, a severe allergic reaction to Gemtesa may occur. Seek prompt medical attention if any of the following symptoms manifest: 

• Rash 
• Difficult breathing 
• Severe dizziness 
• Swelling and itching, particularly of the face, tongue, or throat, 

The adverse effects of Gemtesa listed here are not exhaustive. Notify your doctor right away if any unmentioned side effects occur and cause discomfort. 

Cautions 

Before starting treatment with Gemtesa, tell your healthcare provider or pharmacist if you have any known hypersensitivity, especially to vibegron and other medications. 

Inactive ingredients of Gemtesa may also trigger allergic reactions or cause problems. Obtaining the complete list of ingredients of this medication to a pharmacist is recommended. 

To ensure Gemtesa is safe for you, disclose to your doctor your medical history, specifically of: 

• Other bladder conditions, such as difficulty in emptying the bladder or a weak urine stream 
• Kidney issues 
• Liver problems 

To prevent any possible drug interactions, inform both your doctor and pharmacist of any current or anticipated usage of prescription or non-prescription medications, dietary supplements, vitamins, and herbal products before initiating treatment with Gemtesa. 

Be mindful of telling them if you are taking any medications listed below, as they may require dosage adjustments or close monitoring for potential side effects. 

• Darifenacin (Enablex) 
• Digoxin (Lanoxin) 
• Oxybutynin (Oxytrol) 
• Solifenacin (Vesicare LS) 
• Tolterodine (Detrol LA) 
• Trospium 

The use of Gemtesa during pregnancy is only recommended if there is a clear need. Discuss with your doctor to assess the potential risks and benefits. 

The transfer of vibegron into breast milk remains uncertain. Seek counsel from your healthcare provider before nursing.