Glucotrol (Glipizide) Medication


Glucotrol (Glipizide)

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Table of contents:

Drug Description


In conjunction with a suitable diet and exercise program, Glipizide is utilized to regulate elevated blood sugar levels in individuals diagnosed with type 2 diabetes. It can be employed alongside other diabetes medications as well. Effective management of high blood sugar aids in the prevention of complications such as kidney damage, blindness, neuropathy, limb loss, and sexual function issues. In addition, proper diabetes control can potentially reduce the risk of heart attacks and strokes. Glipizide belongs to the class of medications known as sulfonylureas, which stimulate the release of endogenous insulin within your body, lowering blood sugar levels. 

Uses and Dosage 

Take this medication orally, 30 minutes prior to breakfast or the initial meal of the day, as prescribed by your doctor, typically once daily. Sometimes, particularly with higher dosages, your doctor may instruct you to take this medication twice daily. The specific dosage will be determined based on your medical condition and response to treatment. 

To minimize the risk of side effects, your doctor may advise you to initiate treatment with a low dose and gradually increase it. Carefully follow your doctor’s instructions. 

If you are currently using another diabetes medication, such as chlorpropamide, adhere to your doctor’s guidance regarding discontinuing the previous medication and initiating glipizide. 

Please note that colesevelam can reduce the absorption of glipizide. If you are taking colesevelam, take glipizide at least 4 hours before consuming colesevelam. 

Consistent use of this medication is vital to derive maximum benefit from it. To aid in remembering, take it at the same time(s) each day. 

Inform your doctor if there is no improvement in your condition or if it worsens (e.g. if your blood sugar levels remain excessively high or low). 

Side Effects 

Promptly contact your doctor if you experience symptoms of low blood sugar, such as: 

  • Headache 
  • Irritability 
  • Sweating 
  • Rapid heart rate 
  • Dizziness 
  • Nausea 
  • Feelings of hunger, anxiety, or shakiness 

Common Side Effects

Common side effects of Glucotrol may encompass: 

  • Diarrhea 
  • Constipation 
  • Gas 
  • Dizziness 
  • Drowsiness 
  • Tremors 
  • Skin rash accompanied by redness or itching 

Allergic Reaction

In the event of an allergic reaction to Glucotrol (generic name: glipizide), seek immediate medical assistance. Signs of an allergic reaction may include the presence of: 

  • Hives 
  • Difficulty breathing 
  • Swelling of the face, lips, tongue, or throat 


Before initiating glipizide treatment, inform your doctor or pharmacist about any known allergies, including allergies to glipizide or other substances. This medication may contain inactive ingredients that trigger allergic reactions or other complications. Consult your pharmacist for further details. 

Before using this medication, disclose your medical history to your doctor or pharmacist, particularly if you have a history of liver disease, kidney disease, thyroid disease, certain hormonal conditions (such as adrenal/pituitary insufficiency or syndrome of inappropriate secretion of antidiuretic hormone-SIADH), or electrolyte imbalance (specifically hyponatremia). 

Extreme low or high blood sugar levels may cause blurred vision, dizziness, or drowsiness. Refrain from driving, operating machinery, or engaging in activities that require alertness or clear vision until you are confident in your ability to perform them safely. 

While taking this medication, limit alcohol consumption as it can increase the risk of developing low blood sugar. In addition, alcohol may rarely interact with glipizide, potentially causing a severe reaction known as a disulfiram-like reaction. Symptoms of this reaction may include facial flushing, nausea, vomiting, dizziness, or stomach pain. Consult your doctor or pharmacist to ensure the safe use of alcohol. 

Controlling blood sugar levels may be more challenging during periods of bodily stress, such as fever, infection, injury, or surgery. Consult your doctor as such circumstances may necessitate modifications in your treatment plan, medications, or blood sugar testing. 

Additional information

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Quality Prescription Drugs has provided information from third parties intended to increase awareness and does not contain all the information about Glucotrol (Glipizide). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Glucotrol (Glipizide).