Indications 

Lanoxin is a prescription medication indicated for the following purposes: 

• Management of mild to moderate heart failure in adult patients 
• Enhancement of myocardial contractility in pediatric patients with heart failure 
• Regulation of resting ventricular rate in adult patients with chronic atrial fibrillation 

Classified as a cardiac glycoside medication, Lanoxin exerts its effects by modulating specific minerals (sodium and potassium) within cardiac cells. This mechanism alleviates cardiac strain, fostering a regular, steady, and strong heartbeat. 

Uses and Dosage 

Before taking Lanoxin and with each prescription refill, thoroughly review its medication guide and patient information leaflet. Consult your doctor or pharmacist for any inquiries or concerns. 

The dosage of Lanoxin is determined based on the patient’s medical condition, age, body weight, laboratory tests, and response to the treatment. 

Typically, Lanoxin is taken once a day or as prescribed by the doctor since dosing can be initiated in two ways: with a loading dose followed by maintenance dosing for rapid titration if desired or with maintenance dosing alone without a loading dose. 

For optimal results, take this medication consistently around the same time(s) every day. Do not exceed or reduce the prescribed dosage, nor take it more frequently than instructed by your doctor. 

Keep taking Lanoxin even if you feel well. Do not discontinue treatment without consulting your doctor; certain conditions may deteriorate if this medication is abruptly stopped. 

Side Effects 

Listed below are the potential adverse effects of Lanoxin. Promptly inform your physician if any of these symptoms persist or deteriorate. 

Common Side Effects 

• Nausea 
• Vomiting 
• Diarrhea 
• Loss of appetite 
• Weakness 
• Dizziness 
• Headache 
• Anxiety 
• Depression 
• Slow heart rate (bradycardia) 
• Enlarged or tender breasts in men 
• Skin rash 

Serious Side Effects 

• Mental/mood changes 
• Vision changes (e.g. blurred or yellow/green vision) 

Tell your doctor promptly if you experience any of the severe side effects listed above. 

Allergic Reactions 

Although rare, a severe allergic reaction to Lanoxin may occur. Seek medical attention immediately if you experience symptoms such as: 

• Rash 
• Itching 
• Swelling (particularly of the face, throat, or tongue) 
• Severe dizziness 
• Difficulty breathing 

This list does not contain all the potential side effects of Lanoxin. If any unlisted effects occur, tell your doctor promptly. 

Cautions 

Before starting treatment with Lanoxin, inform your doctor and pharmacist if you have any known hypersensitivities, especially to: 

• Digoxin 
• Similar drugs (e.g., digitoxin) 
• Other medications 
• Any ingredients of Lanoxin tablets 

To ensure Lanoxin is safe for you, disclose to your physician your medical background, especially if you have a history of: 

• Kidney problems 
• Thyroid problems (underactive or overactive) 

Inform all your healthcare providers of all the medications you are currently taking, including prescription and non-prescription drugs, dietary supplements, and herbal products, to prevent drug interaction with Lanoxin. 

The effectiveness of Lanoxin may be influenced by the presence of other medications that impact its elimination from the body. Examples of such medications include: 

• Azole antifungals (like itraconazole) 
• Dronedarone 
• Lapatinib 
• Macrolide antibiotics (such as clarithromycin, erythromycin) 
• Propafenone 
• St. John’s wort and others 

Inform your doctor and pharmacist if you currently use cough-and-cold products, diet aids, or NSAIDs like ibuprofen and naproxen, as some ingredients may exacerbate heart failure. Seek guidance on safe usage. 

The absorption of Lanoxin may be affected if consumed with high-fiber foods. To ensure optimal absorption, take this medication at least 2 hours before or after consuming high-fiber food products (e.g., bran). 

Allow an interval of at least 2 hours after taking Lanoxin before cholestyramine, colestipol, or psyllium. 

For antacids, kaolin-pectin, milk of magnesia, metoclopramide, sulfasalazine, or aminosalicylic acid, separate their intake from Lanoxin as much as possible. Consult your pharmacist if you are unsure about the timing of any medications. 

Lanoxin may cause drowsiness. Avoid driving a vehicle or operating machinery until you understand how this medication affects you. 

The use of Lanoxin during pregnancy should only occur when there is a clear necessity. Discuss with your doctor the risks and benefits associated with its use. 

Digoxin is excreted in breast milk, but there are no known adverse effects on nursing infants. Nevertheless, consult with your doctor before breastfeeding when taking this medication.